TAAR3 (taar3_human)
FAMILY
Class A (Rhodopsin) Orphan receptors Class A orphans TAAR3
GENE
TAAR3P (GPR57, TAAR3)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Putative trace amine-associated receptor 3, TaR-3, Trace amine receptor 3, hTaar3, G-protein coupled receptor 57
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
D
|
L
|
T
|
Y
|
I
|
P
|
E
|
D
|
L
|
10 |
S
|
S
|
C
|
P
|
K
|
F
|
V
|
N
|
K
|
I
|
20 |
TM1 | |||||||||
L
|
S
|
S
|
H
|
Q
|
P
|
L
|
F
|
S
|
C
|
30 |
P
|
G
|
D
|
N
|
V
|
F
|
G
|
Y
|
D
|
W
|
40 |
S
|
H
|
D
|
Y
|
P
|
L
|
F
|
G
|
N
|
L
|
50 |
V
|
I
|
M
|
V
|
S
|
I
|
S
|
H
|
F
|
K
|
60 |
ICL1 | TM2 | ||||||||
Q
|
L
|
H
|
S
|
P
|
T
|
N
|
F
|
L
|
I
|
70 |
L
|
S
|
M
|
A
|
T
|
T
|
D
|
F
|
L
|
L
|
80 |
G
|
F
|
V
|
I
|
M
|
P
|
Y
|
S
|
I
|
M
|
90 |
ECL1 | |||||||||
R
|
S
|
V
|
E
|
S
|
C
|
W
|
Y
|
F
|
G
|
100 |
TM3 | |||||||||
D
|
G
|
F
|
C
|
K
|
F
|
H
|
T
|
S
|
F
|
110 |
D
|
M
|
M
|
L
|
R
|
L
|
T
|
S
|
I
|
F
|
120 |
H
|
L
|
C
|
S
|
I
|
A
|
I
|
D
|
R
|
F
|
130 |
ICL2 | |||||||||
Y
|
A
|
V
|
C
|
Y
|
P
|
L
|
H
|
Y
|
T
|
140 |
TM4 | |||||||||
T
|
K
|
M
|
T
|
N
|
S
|
T
|
I
|
K
|
Q
|
150 |
L
|
L
|
A
|
F
|
C
|
W
|
S
|
V
|
P
|
A
|
160 |
L
|
F
|
S
|
F
|
G
|
L
|
V
|
L
|
S
|
E
|
170 |
ECL2 | |||||||||
A
|
D
|
V
|
S
|
G
|
M
|
Q
|
S
|
Y
|
K
|
180 |
I
|
L
|
V
|
A
|
C
|
F
|
N
|
F
|
C
|
A
|
190 |
TM5 | |||||||||
L
|
T
|
F
|
N
|
K
|
F
|
W
|
G
|
T
|
I
|
200 |
L
|
F
|
T
|
T
|
C
|
F
|
F
|
T
|
P
|
G
|
210 |
S
|
I
|
M
|
V
|
G
|
I
|
Y
|
G
|
K
|
I
|
220 |
F
|
I
|
V
|
S
|
K
|
Q
|
H
|
A
|
R
|
V
|
230 |
I
|
S
|
H
|
V
|
P
|
E
|
N
|
T
|
K
|
G
|
240 |
ICL3 | TM6 | ||||||||
A
|
V
|
K
|
K
|
H
|
L
|
S
|
K
|
K
|
K
|
250 |
D
|
R
|
K
|
A
|
A
|
K
|
T
|
L
|
G
|
I
|
260 |
V
|
M
|
G
|
V
|
F
|
L
|
A
|
C
|
W
|
L
|
270 |
P
|
C
|
F
|
L
|
A
|
V
|
L
|
I
|
D
|
P
|
280 |
ECL3 | TM7 | ||||||||
Y
|
L
|
D
|
Y
|
S
|
T
|
P
|
I
|
L
|
I
|
290 |
L
|
D
|
L
|
L
|
V
|
W
|
L
|
R
|
Y
|
F
|
300 |
N
|
S
|
T
|
C
|
N
|
P
|
L
|
I
|
H
|
G
|
310 |
H8 | |||||||||
F
|
F
|
N
|
P
|
W
|
F
|
Q
|
K
|
A
|
F
|
320 |
K
|
Y
|
I
|
V
|
S
|
G
|
K
|
I
|
F
|
S
|
330 |
C-term | |||||||||
S
|
H
|
S
|
E
|
T
|
A
|
N
|
L
|
F
|
P
|
340 |
E
|
A
|
H
|
LINKS
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
isoamylamine
STRUCTURE MODELS
STRUCTURES
No structures available