GPR31 (gpr31_human)
FAMILY
Class A (Rhodopsin) Orphan receptors Class A orphans GPR31
GENE
GPR31
ORGANISM
Human (Homo sapiens)
ALT. NAMES
12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor, 12-(S)-HETE receptor, 12-HETER, G-protein coupled receptor 31, GPR31/12-HETER
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
P
|
F
|
P
|
N
|
C
|
S
|
A
|
P
|
S
|
10 |
TM1 | |||||||||
T
|
V
|
V
|
A
|
T
|
A
|
V
|
G
|
V
|
L
|
20 |
L
|
G
|
L
|
E
|
C
|
G
|
L
|
G
|
L
|
L
|
30 |
G
|
N
|
A
|
V
|
A
|
L
|
W
|
T
|
F
|
L
|
40 |
ICL1 | TM2 | ||||||||
F
|
R
|
V
|
R
|
V
|
W
|
K
|
P
|
Y
|
A
|
50 |
V
|
Y
|
L
|
L
|
N
|
L
|
A
|
L
|
A
|
D
|
60 |
L
|
L
|
L
|
A
|
A
|
C
|
L
|
P
|
F
|
L
|
70 |
ECL1 | |||||||||
A
|
A
|
F
|
Y
|
L
|
S
|
L
|
Q
|
A
|
W
|
80 |
TM3 | |||||||||
H
|
L
|
G
|
R
|
V
|
G
|
C
|
W
|
A
|
L
|
90 |
H
|
F
|
L
|
L
|
D
|
L
|
S
|
R
|
S
|
V
|
100 |
G
|
M
|
A
|
F
|
L
|
A
|
A
|
V
|
A
|
L
|
110 |
D
|
R
|
Y
|
L
|
R
|
V
|
V
|
H
|
P
|
R
|
120 |
ICL2 | |||||||||
L
|
K
|
V
|
N
|
L
|
L
|
S
|
P
|
Q
|
A
|
130 |
TM4 | |||||||||
A
|
L
|
G
|
V
|
S
|
G
|
L
|
V
|
W
|
L
|
140 |
L
|
M
|
V
|
A
|
L
|
T
|
C
|
P
|
G
|
L
|
150 |
ECL2 | |||||||||
L
|
I
|
S
|
E
|
A
|
A
|
Q
|
N
|
S
|
T
|
160 |
R
|
C
|
H
|
S
|
F
|
Y
|
S
|
R
|
A
|
D
|
170 |
TM5 | |||||||||
G
|
S
|
F
|
S
|
I
|
I
|
W
|
Q
|
E
|
A
|
180 |
L
|
S
|
C
|
L
|
Q
|
F
|
V
|
L
|
P
|
F
|
190 |
G
|
L
|
I
|
V
|
F
|
C
|
N
|
A
|
G
|
I
|
200 |
I
|
R
|
A
|
L
|
Q
|
K
|
R
|
L
|
R
|
E
|
210 |
TM6 | |||||||||
P
|
E
|
K
|
Q
|
P
|
K
|
L
|
Q
|
R
|
A
|
220 |
Q
|
A
|
L
|
V
|
T
|
L
|
V
|
V
|
V
|
L
|
230 |
F
|
A
|
L
|
C
|
F
|
L
|
P
|
C
|
F
|
L
|
240 |
A
|
R
|
V
|
L
|
M
|
H
|
I
|
F
|
Q
|
N
|
250 |
ECL3 | TM7 | ||||||||
L
|
G
|
S
|
C
|
R
|
A
|
L
|
C
|
A
|
V
|
260 |
A
|
H
|
T
|
S
|
D
|
V
|
T
|
G
|
S
|
L
|
270 |
T
|
Y
|
L
|
H
|
S
|
V
|
L
|
N
|
P
|
V
|
280 |
H8 | |||||||||
V
|
Y
|
C
|
F
|
S
|
S
|
P
|
T
|
F
|
R
|
290 |
S
|
S
|
Y
|
R
|
R
|
V
|
F
|
H
|
T
|
L
|
300 |
C-term | |||||||||
R
|
G
|
K
|
G
|
Q
|
A
|
A
|
E
|
P
|
P
|
310 |
D
|
F
|
N
|
P
|
R
|
D
|
S
|
Y
|
S
|
LINKS
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
12S-HETE
STRUCTURE MODELS
STRUCTURES
No structures available