S1P2 receptor - G13

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

G12/13

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7T6B

RESOLUTION

3.2 Å

REFERENCE

10.1126/SCIADV.ABN0067

PUBLICATION DATE

April 6, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

43 interactions (Click to see)

LIGANDS

sphingosine 1-phosphate - Agonist pubchem gtoplig chembl_ligand pubchem

ENDOGENOUS LIGANDS

sphingosylphosphorylcholine, dihydrosphingosine 1-phosphate, sphingosine 1-phosphate



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL1 S 66 - G.H5 Q 373 G.H5.22
Hydrophobic ICL1 S 66 - G.H5 Q 373 G.H5.22
Van-der-waals ICL1 S 66 - G.H5 Q 373 G.H5.22
Hydrophobic TM3 I 134 3x54 G.H5 L 376 G.H5.25
Hydrophobic TM3 I 134 3x54 G.H5 L 374 G.H5.23
Hydrophobic TM6 T 228 6x30 G.H5 H 368 G.H5.17
Hydrophobic ICL2 L 139 - G.H5 N 370 G.H5.19
Van-der-waals ICL2 L 139 - G.H5 N 370 G.H5.19
Hydrophobic TM5 S 219 5x68 G.H5 L 367 G.H5.16
Van-der-waals TM5 S 219 5x68 G.H5 L 367 G.H5.16
Hydrophobic TM2 Y 69 2x40 G.H5 M 375 G.H5.24
Van-der-waals TM2 Y 69 2x40 G.H5 M 375 G.H5.24
Hydrophobic TM6 V 235 6x37 G.H5 Q 377 G.H5.26
Van-der-waals TM6 V 235 6x37 G.H5 Q 377 G.H5.26
Hydrophobic ICL2 Y 140 - G.H5 Q 373 G.H5.22
Van-der-waals ICL2 Y 140 - G.H5 Q 373 G.H5.22
Hydrophobic TM2 L 72 2x43 G.H5 M 375 G.H5.24
Hydrophobic TM5 Y 209 5x58 G.H5 L 376 G.H5.25
Hydrophobic TM5 V 216 5x65 G.H5 L 367 G.H5.16
Hydrophobic ICL2 L 139 - G.H5 D 369 G.H5.18
Van-der-waals ICL2 L 139 - G.H5 D 369 G.H5.18
Hydrophobic ICL2 V 137 - G.H5 F 359 G.H5.08
Polar ICL2 K 138 - G.H5 N 370 G.H5.19
Van-der-waals ICL2 K 138 - G.H5 N 370 G.H5.19
Hydrophobic ICL2 L 139 - G.H5 I 366 G.H5.15
Hydrophobic TM5 I 212 5x61 G.H5 L 376 G.H5.25
Van-der-waals TM5 I 212 5x61 G.H5 L 376 G.H5.25
Van-der-waals TM7 Y 288 7x53 G.H5 M 375 G.H5.24
Polar TM3 A 133 3x53 G.H5 N 370 G.H5.19
Hydrophobic ICL2 V 137 - G.H5 I 366 G.H5.15
Hydrophobic ICL2 K 138 - G.H5 I 366 G.H5.15
Hydrophobic TM2 M 68 2x39 G.H5 M 375 G.H5.24
Hydrophobic TM3 A 133 3x53 G.H5 L 374 G.H5.23
Van-der-waals TM3 A 133 3x53 G.H5 L 374 G.H5.23
Polar ICL2 Y 140 - G.H5 N 370 G.H5.19
Hydrophobic ICL2 Y 140 - G.H5 N 370 G.H5.19
Van-der-waals ICL2 Y 140 - G.H5 N 370 G.H5.19
Hydrophobic ICL2 V 137 - G.S3 V 216 G.S3.01
Hydrophobic ICL2 V 137 - G.H5 K 363 G.H5.12
Hydrophobic ICL2 K 138 - G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 Y 140 - G.H5 L 374 G.H5.23
Van-der-waals ICL2 Y 140 - G.H5 L 374 G.H5.23
Hydrophobic ICL2 K 138 - G.HN A 31 G.HN.40
Hydrophobic TM6 L 232 6x34 G.H5 L 371 G.H5.20
Van-der-waals TM6 L 232 6x34 G.H5 L 371 G.H5.20
Polar TM6 T 228 6x30 G.H5 Q 377 G.H5.26
Van-der-waals TM6 T 228 6x30 G.H5 Q 377 G.H5.26
Hydrophobic TM2 M 68 2x39 G.H5 L 374 G.H5.23
Van-der-waals TM2 M 68 2x39 G.H5 L 374 G.H5.23
Hydrophobic TM3 I 134 3x54 G.H5 L 371 G.H5.20
Van-der-waals TM3 I 134 3x54 G.H5 L 371 G.H5.20
Hydrophobic TM6 T 228 6x30 G.H5 L 371 G.H5.20
Hydrophobic TM5 V 216 5x65 G.H5 L 371 G.H5.20
Hydrophobic TM3 R 130 3x50 G.H5 L 376 G.H5.25
Polar TM3 R 130 3x50 G.H5 L 374 G.H5.23
Hydrophobic TM3 R 130 3x50 G.H5 L 374 G.H5.23
Van-der-waals TM3 R 130 3x50 G.H5 L 374 G.H5.23