S1P2 receptor (s1pr2_human)
FAMILY
Class A (Rhodopsin) Lipid receptors Lysophospholipid (S1P) receptors S1P2 receptor
GENE
S1PR2 (EDG5)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Sphingosine 1-phosphate receptor 2, S1P receptor 2, S1P2, Endothelial differentiation G-protein coupled receptor 5, Sphingosine 1-phosphate receptor Edg-5, S1P receptor Edg-5
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
G
|
S
|
L
|
Y
|
S
|
E
|
Y
|
L
|
N
|
10 |
P
|
N
|
K
|
V
|
Q
|
E
|
H
|
Y
|
N
|
Y
|
20 |
T
|
K
|
E
|
T
|
L
|
E
|
T
|
Q
|
E
|
T
|
30 |
TM1 | |||||||||
T
|
S
|
R
|
Q
|
V
|
A
|
S
|
A
|
F
|
I
|
40 |
V
|
I
|
L
|
C
|
C
|
A
|
I
|
V
|
V
|
E
|
50 |
N
|
L
|
L
|
V
|
L
|
I
|
A
|
V
|
A
|
R
|
60 |
ICL1 | TM2 | ||||||||
N
|
S
|
K
|
F
|
H
|
S
|
A
|
M
|
Y
|
L
|
70 |
F
|
L
|
G
|
N
|
L
|
A
|
A
|
S
|
D
|
L
|
80 |
L
|
A
|
G
|
V
|
A
|
F
|
V
|
A
|
N
|
T
|
90 |
ECL1 | |||||||||
L
|
L
|
S
|
G
|
S
|
V
|
T
|
L
|
R
|
L
|
100 |
TM3 | |||||||||
T
|
P
|
V
|
Q
|
W
|
F
|
A
|
R
|
E
|
G
|
110 |
S
|
A
|
F
|
I
|
T
|
L
|
S
|
A
|
S
|
V
|
120 |
F
|
S
|
L
|
L
|
A
|
I
|
A
|
I
|
E
|
R
|
130 |
ICL2 | |||||||||
H
|
V
|
A
|
I
|
A
|
K
|
V
|
K
|
L
|
Y
|
140 |
TM4 | |||||||||
G
|
S
|
D
|
K
|
S
|
C
|
R
|
M
|
L
|
L
|
150 |
L
|
I
|
G
|
A
|
S
|
W
|
L
|
I
|
S
|
L
|
160 |
V
|
L
|
G
|
G
|
L
|
P
|
I
|
L
|
G
|
W
|
170 |
ECL2 | |||||||||
N
|
C
|
L
|
G
|
H
|
L
|
E
|
A
|
C
|
S
|
180 |
TM5 | |||||||||
T
|
V
|
L
|
P
|
L
|
Y
|
A
|
K
|
H
|
Y
|
190 |
V
|
L
|
C
|
V
|
V
|
T
|
I
|
F
|
S
|
I
|
200 |
I
|
L
|
L
|
A
|
I
|
V
|
A
|
L
|
Y
|
V
|
210 |
R
|
I
|
Y
|
C
|
V
|
V
|
R
|
S
|
S
|
H
|
220 |
ICL3 | TM6 | ||||||||
A
|
D
|
M
|
A
|
A
|
P
|
Q
|
T
|
L
|
A
|
230 |
L
|
L
|
K
|
T
|
V
|
T
|
I
|
V
|
L
|
G
|
240 |
V
|
F
|
I
|
V
|
C
|
W
|
L
|
P
|
A
|
F
|
250 |
S
|
I
|
L
|
L
|
L
|
D
|
Y
|
A
|
C
|
P
|
260 |
ECL3 | TM7 | ||||||||
V
|
H
|
S
|
C
|
P
|
I
|
L
|
Y
|
K
|
A
|
270 |
H
|
Y
|
F
|
F
|
A
|
V
|
S
|
T
|
L
|
N
|
280 |
S
|
L
|
L
|
N
|
P
|
V
|
I
|
Y
|
T
|
W
|
290 |
H8 | |||||||||
R
|
S
|
R
|
D
|
L
|
R
|
R
|
E
|
V
|
L
|
300 |
C-term | |||||||||
R
|
P
|
L
|
Q
|
C
|
W
|
R
|
P
|
G
|
V
|
310 |
G
|
V
|
Q
|
G
|
R
|
R
|
R
|
G
|
G
|
T
|
320 |
P
|
G
|
H
|
H
|
L
|
L
|
P
|
L
|
R
|
S
|
330 |
S
|
S
|
S
|
L
|
E
|
R
|
G
|
M
|
H
|
M
|
340 |
P
|
T
|
S
|
P
|
T
|
F
|
L
|
E
|
G
|
N
|
350 |
T
|
V
|
V
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
sphingosine 1-phosphate, dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine
STRUCTURE MODELS
STRUCTURES
Found 1 structure(s) - view all details on the Structures page
PDBs: 7T6B