TP receptor (ta2r_human)
FAMILY
Class A (Rhodopsin) Lipid receptors Prostanoid receptors TP receptor
GENE
TBXA2R
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Thromboxane A2 receptor, TXA2-R, Prostanoid TP receptor
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
W
|
P
|
N
|
G
|
S
|
S
|
L
|
G
|
P
|
10 |
C
|
F
|
R
|
P
|
T
|
N
|
I
|
T
|
L
|
E
|
20 |
TM1 | |||||||||
E
|
R
|
R
|
L
|
I
|
A
|
S
|
P
|
W
|
F
|
30 |
A
|
A
|
S
|
F
|
C
|
V
|
V
|
G
|
L
|
A
|
40 |
S
|
N
|
L
|
L
|
A
|
L
|
S
|
V
|
L
|
A
|
50 |
ICL1 | |||||||||
G
|
A
|
R
|
Q
|
G
|
G
|
S
|
H
|
T
|
R
|
60 |
TM2 | |||||||||
S
|
S
|
F
|
L
|
T
|
F
|
L
|
C
|
G
|
L
|
70 |
V
|
L
|
T
|
D
|
F
|
L
|
G
|
L
|
L
|
V
|
80 |
T
|
G
|
T
|
I
|
V
|
V
|
S
|
Q
|
H
|
A
|
90 |
ECL1 | |||||||||
A
|
L
|
F
|
E
|
W
|
H
|
A
|
V
|
D
|
P
|
100 |
TM3 | |||||||||
G
|
C
|
R
|
L
|
C
|
R
|
F
|
M
|
G
|
V
|
110 |
V
|
M
|
I
|
F
|
F
|
G
|
L
|
S
|
P
|
L
|
120 |
L
|
L
|
G
|
A
|
A
|
M
|
A
|
S
|
E
|
R
|
130 |
ICL2 | |||||||||
Y
|
L
|
G
|
I
|
T
|
R
|
P
|
F
|
S
|
R
|
140 |
TM4 | |||||||||
P
|
A
|
V
|
A
|
S
|
Q
|
R
|
R
|
A
|
W
|
150 |
A
|
T
|
V
|
G
|
L
|
V
|
W
|
A
|
A
|
A
|
160 |
L
|
A
|
L
|
G
|
L
|
L
|
P
|
L
|
L
|
G
|
170 |
ECL2 | |||||||||
V
|
G
|
R
|
Y
|
T
|
V
|
Q
|
Y
|
P
|
G
|
180 |
S
|
W
|
C
|
F
|
L
|
T
|
L
|
G
|
A
|
E
|
190 |
TM5 | |||||||||
S
|
G
|
D
|
V
|
A
|
F
|
G
|
L
|
L
|
F
|
200 |
S
|
M
|
L
|
G
|
G
|
L
|
S
|
V
|
G
|
L
|
210 |
S
|
F
|
L
|
L
|
N
|
T
|
V
|
S
|
V
|
A
|
220 |
T
|
L
|
C
|
H
|
V
|
Y
|
H
|
G
|
Q
|
E
|
230 |
ICL3 | TM6 | ||||||||
A
|
A
|
Q
|
Q
|
R
|
P
|
R
|
D
|
S
|
E
|
240 |
V
|
E
|
M
|
M
|
A
|
Q
|
L
|
L
|
G
|
I
|
250 |
M
|
V
|
V
|
A
|
S
|
V
|
C
|
W
|
L
|
P
|
260 |
L
|
L
|
V
|
F
|
I
|
A
|
Q
|
T
|
V
|
L
|
270 |
ECL3 | |||||||||
R
|
N
|
P
|
P
|
A
|
M
|
S
|
P
|
A
|
G
|
280 |
TM7 | |||||||||
Q
|
L
|
S
|
R
|
T
|
T
|
E
|
K
|
E
|
L
|
290 |
L
|
I
|
Y
|
L
|
R
|
V
|
A
|
T
|
W
|
N
|
300 |
Q
|
I
|
L
|
D
|
P
|
W
|
V
|
Y
|
I
|
L
|
310 |
H8 | |||||||||
F
|
R
|
R
|
A
|
V
|
L
|
R
|
R
|
L
|
Q
|
320 |
P
|
R
|
L
|
S
|
T
|
R
|
P
|
R
|
S
|
L
|
330 |
C-term | |||||||||
S
|
L
|
Q
|
P
|
Q
|
L
|
T
|
Q
|
R
|
S
|
340 |
G
|
L
|
Q
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
PGF2α, PGH2, PGI2, PGD2, thromboxane A2, PGE2
STRUCTURE MODELS
STRUCTURES
Found 2 structure(s) - view all details on the Structures page