ACKR2 (ackr2_human)
FAMILY
Class A (Rhodopsin) Protein receptors Chemokine receptors ACKR2
GENE
ACKR2 (CCBP2, CCR10, CMKBR9, D6)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Atypical chemokine receptor 2, C-C chemokine receptor D6, Chemokine receptor CCR-10, Chemokine receptor CCR-9, Chemokine-binding protein 2, Chemokine-binding protein D6
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
A
|
A
|
T
|
A
|
S
|
P
|
Q
|
P
|
L
|
10 |
A
|
T
|
E
|
D
|
A
|
D
|
S
|
E
|
N
|
S
|
20 |
S
|
F
|
Y
|
Y
|
Y
|
D
|
Y
|
L
|
D
|
E
|
30 |
TM1 | |||||||||
V
|
A
|
F
|
M
|
L
|
C
|
R
|
K
|
D
|
A
|
40 |
V
|
V
|
S
|
F
|
G
|
K
|
V
|
F
|
L
|
P
|
50 |
V
|
F
|
Y
|
S
|
L
|
I
|
F
|
V
|
L
|
G
|
60 |
L
|
S
|
G
|
N
|
L
|
L
|
L
|
L
|
M
|
V
|
70 |
ICL1 | |||||||||
L
|
L
|
R
|
Y
|
V
|
P
|
R
|
R
|
R
|
M
|
80 |
TM2 | |||||||||
V
|
E
|
I
|
Y
|
L
|
L
|
N
|
L
|
A
|
I
|
90 |
S
|
N
|
L
|
L
|
F
|
L
|
V
|
T
|
L
|
P
|
100 |
F
|
W
|
G
|
I
|
S
|
V
|
A
|
W
|
H
|
W
|
110 |
ECL1 | TM3 | ||||||||
V
|
F
|
G
|
S
|
F
|
L
|
C
|
K
|
M
|
V
|
120 |
S
|
T
|
L
|
Y
|
T
|
I
|
N
|
F
|
Y
|
S
|
130 |
G
|
I
|
F
|
F
|
I
|
S
|
C
|
M
|
S
|
L
|
140 |
D
|
K
|
Y
|
L
|
E
|
I
|
V
|
H
|
A
|
Q
|
150 |
ICL2 | TM4 | ||||||||
P
|
Y
|
H
|
R
|
L
|
R
|
T
|
R
|
A
|
K
|
160 |
S
|
L
|
L
|
L
|
A
|
T
|
I
|
V
|
W
|
A
|
170 |
V
|
S
|
L
|
A
|
V
|
S
|
I
|
P
|
D
|
M
|
180 |
ECL2 | |||||||||
V
|
F
|
V
|
Q
|
T
|
H
|
E
|
N
|
P
|
K
|
190 |
G
|
V
|
W
|
N
|
C
|
H
|
A
|
D
|
F
|
G
|
200 |
TM5 | |||||||||
G
|
H
|
G
|
T
|
I
|
W
|
K
|
L
|
F
|
L
|
210 |
R
|
F
|
Q
|
Q
|
N
|
L
|
L
|
G
|
F
|
L
|
220 |
L
|
P
|
L
|
L
|
A
|
M
|
I
|
F
|
F
|
Y
|
230 |
S
|
R
|
I
|
G
|
C
|
V
|
L
|
V
|
R
|
L
|
240 |
ICL3 | TM6 | ||||||||
R
|
P
|
A
|
G
|
Q
|
G
|
R
|
A
|
L
|
K
|
250 |
I
|
A
|
A
|
A
|
L
|
V
|
V
|
A
|
F
|
F
|
260 |
V
|
L
|
W
|
F
|
P
|
Y
|
N
|
L
|
T
|
L
|
270 |
F
|
L
|
H
|
T
|
L
|
L
|
D
|
L
|
Q
|
V
|
280 |
ECL3 | TM7 | ||||||||
F
|
G
|
N
|
C
|
E
|
V
|
S
|
Q
|
H
|
L
|
290 |
D
|
Y
|
A
|
L
|
Q
|
V
|
T
|
E
|
S
|
I
|
300 |
A
|
F
|
L
|
H
|
C
|
C
|
F
|
S
|
P
|
I
|
310 |
H8 | |||||||||
L
|
Y
|
A
|
F
|
S
|
S
|
H
|
R
|
F
|
R
|
320 |
Q
|
Y
|
L
|
K
|
A
|
F
|
L
|
A
|
A
|
V
|
330 |
C-term | |||||||||
L
|
G
|
W
|
H
|
L
|
A
|
P
|
G
|
T
|
A
|
340 |
Q
|
A
|
S
|
L
|
S
|
S
|
C
|
S
|
E
|
S
|
350 |
S
|
I
|
L
|
T
|
A
|
Q
|
E
|
E
|
M
|
T
|
360 |
G
|
M
|
N
|
D
|
L
|
G
|
E
|
R
|
Q
|
S
|
370 |
E
|
N
|
Y
|
P
|
N
|
K
|
E
|
D
|
V
|
G
|
380 |
N
|
K
|
S
|
A
|
LINKS
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
CCL11, CCL14, CCL2, CCL8, CCL5, CCL4, CCL22, CCL13, CCL7, CCL3, CCL17
STRUCTURE MODELS
STRUCTURES
No structures available