S1P3 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9WP9

RESOLUTION

3.3 Å

REFERENCE

10.1073/PNAS.2507421122

PUBLICATION DATE

Nov. 26, 2025

3D VIEW

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LIGAND INTERACTIONS

56 interactions (Click to see)

LIGANDS

sphingosine 1-phosphate - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

sphingosine 1-phosphate, dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 Y 146 - G.H5 Y 243 G.H5.23
Hydrophobic TM5 V 229 5x72 G.S6 Y 212 G.S6.02
Van-der-waals TM5 V 229 5x72 G.S6 Y 212 G.S6.02
Hydrophobic TM5 L 221 5x64 G.H5 L 236 G.H5.16
Van-der-waals TM5 L 221 5x64 G.H5 L 236 G.H5.16
Polar ICL2 R 144 - G.H5 N 239 G.H5.19
Van-der-waals ICL2 R 144 - G.H5 N 239 G.H5.19
Hydrophobic TM5 V 222 5x65 G.H5 L 240 G.H5.20
Hydrophobic ICL2 M 143 - G.S1 L 34 G.S1.02
Hydrophobic ICL2 M 143 - G.H5 K 232 G.H5.12
Van-der-waals ICL2 M 143 - G.H5 K 232 G.H5.12
Polar ICL2 Y 146 - G.H5 E 242 G.H5.22
Hydrophobic ICL2 Y 146 - G.H5 E 242 G.H5.22
Van-der-waals ICL2 Y 146 - G.H5 E 242 G.H5.22
Hydrophobic ICL2 R 144 - G.H5 I 235 G.H5.15
Van-der-waals ICL2 R 144 - G.H5 I 235 G.H5.15
Hydrophobic ICL2 M 143 - G.H5 F 228 G.H5.08
Van-der-waals ICL2 M 143 - G.H5 F 228 G.H5.08
Hydrophobic TM5 V 229 5x72 G.H5 D 230 G.H5.10
Hydrophobic TM5 V 222 5x65 G.H5 L 236 G.H5.16
Hydrophobic TM3 M 140 3x54 G.H5 Y 243 G.H5.23
Van-der-waals TM3 M 140 3x54 G.H5 Y 243 G.H5.23
Van-der-waals TM6 N 233 6x25 G.h4s6 I 210 G.h4s6.20
Hydrophobic TM3 R 136 3x50 G.H5 L 245 G.H5.25
Hydrophobic ICL3 N 231 - G.S6 Y 212 G.S6.02
Hydrophobic TM6 L 242 6x34 G.H5 V 246 G.H5.26
Van-der-waals TM6 L 242 6x34 G.H5 V 246 G.H5.26
Hydrophobic TM2 M 74 2x39 G.H5 Y 243 G.H5.23
Hydrophobic TM5 V 229 5x72 G.H5 N 229 G.H5.09
Van-der-waals TM5 V 229 5x72 G.H5 N 229 G.H5.09
Hydrophobic TM5 S 225 5x68 G.H5 L 236 G.H5.16
Hydrophobic TM6 L 242 6x34 G.H5 L 245 G.H5.25
Van-der-waals TM6 L 242 6x34 G.H5 L 245 G.H5.25
Polar ICL2 Y 146 - G.H5 N 239 G.H5.19
Van-der-waals ICL2 Y 146 - G.H5 N 239 G.H5.19
Hydrophobic ICL2 P 145 - G.H5 M 238 G.H5.18
Polar TM3 T 139 3x53 G.H5 Y 243 G.H5.23
Hydrophobic TM3 T 139 3x53 G.H5 Y 243 G.H5.23
Van-der-waals TM3 T 139 3x53 G.H5 Y 243 G.H5.23
Hydrophobic TM5 V 229 5x72 G.H5 D 233 G.H5.13
Van-der-waals TM5 V 229 5x72 G.H5 D 233 G.H5.13
Polar TM3 E 135 3x49 G.H5 Y 243 G.H5.23
Hydrophobic TM3 T 139 3x53 G.H5 N 239 G.H5.19
Hydrophobic ICL2 M 143 - G.H5 I 235 G.H5.15
Van-der-waals ICL2 M 143 - G.H5 I 235 G.H5.15
Hydrophobic ICL2 M 143 - G.S3 F 81 G.S3.03
Hydrophobic TM3 M 140 3x54 G.H5 L 245 G.H5.25
Hydrophobic TM6 V 245 6x37 G.H5 L 245 G.H5.25
Van-der-waals TM6 V 245 6x37 G.H5 L 245 G.H5.25
Hydrophobic ICL2 M 143 - G.S3 V 79 G.S3.01
Polar TM6 S 238 6x30 G.H5 Q 237 G.H5.17
Van-der-waals TM6 S 238 6x30 G.H5 Q 237 G.H5.17
Hydrophobic TM5 I 218 5x61 G.H5 L 245 G.H5.25
Hydrophobic ICL2 P 145 - G.H5 N 239 G.H5.19
Hydrophobic ICL3 N 231 - G.h4s6 I 210 G.h4s6.20
Van-der-waals ICL3 N 231 - G.h4s6 I 210 G.h4s6.20
Polar TM5 S 225 5x68 G.H5 D 233 G.H5.13
Hydrophobic TM5 S 225 5x68 G.H5 D 233 G.H5.13
Van-der-waals TM5 S 225 5x68 G.H5 D 233 G.H5.13
Hydrophobic TM6 L 242 6x34 G.H5 L 240 G.H5.20
Hydrophobic TM6 L 241 6x33 G.H5 V 246 G.H5.26
Hydrophobic TM3 M 140 3x54 G.H5 L 240 G.H5.20
Van-der-waals TM3 M 140 3x54 G.H5 L 240 G.H5.20
Hydrophobic ICL2 M 143 - G.H5 C 231 G.H5.11
Hydrophobic TM3 M 140 3x54 G.H5 N 239 G.H5.19
Van-der-waals TM3 M 140 3x54 G.H5 N 239 G.H5.19
Polar C-term S 302 - G.H5 N 244 G.H5.24
Hydrophobic C-term S 302 - G.H5 N 244 G.H5.24
Van-der-waals C-term S 302 - G.H5 N 244 G.H5.24