P2Y2 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

I

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9K0X

RESOLUTION

2.8 Å

REFERENCE

10.1038/S41421-025-00797-X

PUBLICATION DATE

June 11, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

38 interactions (Click to see)

LIGANDS

ATP - Agonist pubchem gtoplig chembl_ligand drugbank drug_central

PHYSIOLOGICAL LIGANDS

UTP, ATP



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic TM6 K 240 6x31 G.H5 D 381 G.H5.13
Polar TM6 K 240 6x31 G.H5 D 381 G.H5.13
Van-der-waals TM6 K 240 6x31 G.H5 D 381 G.H5.13
Hydrophobic ICL2 L 139 - G.S3 F 219 G.S3.03
Van-der-waals ICL2 R 140 - G.H5 K 380 G.H5.12
Polar TM3 G 134 3x53 G.H5 N 387 G.H5.19
Hydrophobic TM3 G 134 3x53 G.H5 N 387 G.H5.19
Van-der-waals TM3 G 134 3x53 G.H5 N 387 G.H5.19
Hydrophobic TM3 V 135 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM3 V 135 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM6 K 240 6x31 G.H5 L 384 G.H5.26
Polar TM3 H 130 3x49 G.H5 Y 391 G.H5.23
Aromatic TM3 H 130 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 H 130 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 H 130 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 V 135 3x54 G.H5 L 384 G.H5.26
Van-der-waals TM3 V 135 3x54 G.H5 L 384 G.H5.26
Hydrophobic ICL2 R 143 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 R 143 - G.S3 V 217 G.S3.01
Hydrophobic ICL2 L 142 - G.H5 I 383 G.H5.15
Hydrophobic TM6 K 240 6x31 G.H5 L 388 G.H5.20
Hydrophobic TM6 K 242 6x33 G.H5 V 394 G.H5.26
Van-der-waals TM6 K 242 6x33 G.H5 V 394 G.H5.26
Polar TM4 R 146 4x38 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 139 - G.H5 C 379 G.H5.11
Hydrophobic TM6 I 247 6x38 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 139 - G.S3 V 217 G.S3.01
Polar TM6 T 246 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM6 T 246 6x37 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 139 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 139 - G.H5 I 383 G.H5.15
Hydrophobic ICL2 L 139 - G.H5 K 380 G.H5.12
Polar ICL2 R 143 - G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 R 143 - G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 R 143 - G.hns1 A 39 G.hns1.03
Hydrophobic TM6 S 243 6x34 G.H5 L 388 G.H5.20
Hydrophobic ICL2 R 140 - G.H5 F 376 G.H5.08
Polar TM3 R 131 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 131 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 131 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 139 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 139 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 L 142 - G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 P 138 - G.H5 L 384 G.H5.26
Hydrophobic TM5 L 225 5x65 G.H5 L 388 G.H5.20
Hydrophobic ICL2 R 140 - G.S3 V 217 G.S3.01
Hydrophobic TM5 M 221 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 M 221 5x61 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 142 - G.S1 H 41 G.S1.02
Polar TM6 K 242 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 K 242 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 K 242 6x33 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 139 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 139 - G.S1 H 41 G.S1.02
Polar ICL2 R 143 - G.s2s3 K 216 G.s2s3.02
Hydrophobic ICL2 R 143 - G.s2s3 K 216 G.s2s3.02
Van-der-waals ICL2 R 143 - G.s2s3 K 216 G.s2s3.02
Polar TM7 Y 306 7x53 G.H5 N 392 G.H5.24
Van-der-waals TM7 Y 306 7x53 G.H5 N 392 G.H5.24
Hydrophobic TM5 L 225 5x65 G.H5 L 384 G.H5.26
Hydrophobic ICL2 P 138 - G.H5 K 380 G.H5.12
Hydrophobic ICL2 P 138 - G.H5 I 383 G.H5.15
Hydrophobic TM6 A 239 6x30 G.H5 V 394 G.H5.26
Van-der-waals TM6 A 239 6x30 G.H5 V 394 G.H5.26
Van-der-waals TM6 S 243 6x34 G.H5 V 394 G.H5.26
Hydrophobic TM6 K 240 6x31 G.H5 Q 385 G.H5.17
Van-der-waals TM6 K 240 6x31 G.H5 Q 385 G.H5.17
Polar TM6 S 243 6x34 G.H5 L 393 G.H5.25
Hydrophobic TM6 S 243 6x34 G.H5 L 393 G.H5.25
Van-der-waals TM6 S 243 6x34 G.H5 L 393 G.H5.25
Polar TM2 N 66 2x37 G.H5 E 390 G.H5.22
Van-der-waals TM2 N 66 2x37 G.H5 E 390 G.H5.22
Polar TM3 G 134 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 G 134 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 G 134 3x53 G.H5 Y 391 G.H5.23