P2Y4 receptor (p2ry4_human)
FAMILY
Class A (Rhodopsin) Nucleotide receptors P2Y receptors P2Y4 receptor
GENE
P2RY4 (NRU)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
P2Y purinoceptor 4, P2Y4, P2P, Uridine nucleotide receptor, UNR
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
A
|
S
|
T
|
E
|
S
|
S
|
L
|
L
|
R
|
10 |
S
|
L
|
G
|
L
|
S
|
P
|
G
|
P
|
G
|
S
|
20 |
S
|
E
|
V
|
E
|
L
|
D
|
C
|
W
|
F
|
D
|
30 |
TM1 | |||||||||
E
|
D
|
F
|
K
|
F
|
I
|
L
|
L
|
P
|
V
|
40 |
S
|
Y
|
A
|
V
|
V
|
F
|
V
|
L
|
G
|
L
|
50 |
G
|
L
|
N
|
A
|
P
|
T
|
L
|
W
|
L
|
F
|
60 |
ICL1 | TM2 | ||||||||
I
|
F
|
R
|
L
|
R
|
P
|
W
|
D
|
A
|
T
|
70 |
A
|
T
|
Y
|
M
|
F
|
H
|
L
|
A
|
L
|
S
|
80 |
D
|
T
|
L
|
Y
|
V
|
L
|
S
|
L
|
P
|
T
|
90 |
L
|
I
|
Y
|
Y
|
Y
|
A
|
A
|
H
|
N
|
H
|
100 |
ECL1 | TM3 | ||||||||
W
|
P
|
F
|
G
|
T
|
E
|
I
|
C
|
K
|
F
|
110 |
V
|
R
|
F
|
L
|
F
|
Y
|
W
|
N
|
L
|
Y
|
120 |
C
|
S
|
V
|
L
|
F
|
L
|
T
|
C
|
I
|
S
|
130 |
V
|
H
|
R
|
Y
|
L
|
G
|
I
|
C
|
H
|
P
|
140 |
ICL2 | TM4 | ||||||||
L
|
R
|
A
|
L
|
R
|
W
|
G
|
R
|
P
|
R
|
150 |
L
|
A
|
G
|
L
|
L
|
C
|
L
|
A
|
V
|
W
|
160 |
L
|
V
|
V
|
A
|
G
|
C
|
L
|
V
|
P
|
N
|
170 |
ECL2 | |||||||||
L
|
F
|
F
|
V
|
T
|
T
|
S
|
N
|
K
|
G
|
180 |
T
|
T
|
V
|
L
|
C
|
H
|
D
|
T
|
T
|
R
|
190 |
TM5 | |||||||||
P
|
E
|
E
|
F
|
D
|
H
|
Y
|
V
|
H
|
F
|
200 |
S
|
S
|
A
|
V
|
M
|
G
|
L
|
L
|
F
|
G
|
210 |
V
|
P
|
C
|
L
|
V
|
T
|
L
|
V
|
C
|
Y
|
220 |
G
|
L
|
M
|
A
|
R
|
R
|
L
|
Y
|
Q
|
P
|
230 |
ICL3 | TM6 | ||||||||
L
|
P
|
G
|
S
|
A
|
Q
|
S
|
S
|
S
|
R
|
240 |
L
|
R
|
S
|
L
|
R
|
T
|
I
|
A
|
V
|
V
|
250 |
L
|
T
|
V
|
F
|
A
|
V
|
C
|
F
|
V
|
P
|
260 |
F
|
H
|
I
|
T
|
R
|
T
|
I
|
Y
|
Y
|
L
|
270 |
ECL3 | TM7 | ||||||||
A
|
R
|
L
|
L
|
E
|
A
|
D
|
C
|
R
|
V
|
280 |
L
|
N
|
I
|
V
|
N
|
V
|
V
|
Y
|
K
|
V
|
290 |
T
|
R
|
P
|
L
|
A
|
S
|
A
|
N
|
S
|
C
|
300 |
L
|
D
|
P
|
V
|
L
|
Y
|
L
|
L
|
T
|
G
|
310 |
H8 | |||||||||
D
|
K
|
Y
|
R
|
R
|
Q
|
L
|
R
|
Q
|
L
|
320 |
C-term | |||||||||
C
|
G
|
G
|
G
|
K
|
P
|
Q
|
P
|
R
|
T
|
330 |
A
|
A
|
S
|
S
|
L
|
A
|
L
|
V
|
S
|
L
|
340 |
P
|
E
|
D
|
S
|
S
|
C
|
R
|
W
|
A
|
A
|
350 |
T
|
P
|
Q
|
D
|
S
|
S
|
C
|
S
|
T
|
P
|
360 |
R
|
A
|
D
|
R
|
L
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
UTP, ATP
STRUCTURE MODELS
STRUCTURES
No structures available