V1A receptor (v1ar_rat)
FAMILY
Class A (Rhodopsin) Peptide receptors Vasopressin and oxytocin receptors V1A receptor
GENE
Avpr1a
ORGANISM
Rat (Rattus norvegicus)
ALT. NAMES
Vasopressin V1a receptor, V1aR, AVPR V1a, Antidiuretic hormone receptor 1a, Vascular/hepatic-type arginine vasopressin receptor
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
S
|
F
|
P
|
R
|
G
|
S
|
Q
|
D
|
R
|
10 |
S
|
V
|
G
|
N
|
S
|
S
|
P
|
W
|
W
|
P
|
20 |
L
|
T
|
T
|
E
|
G
|
S
|
N
|
G
|
S
|
Q
|
30 |
E
|
A
|
A
|
R
|
L
|
G
|
E
|
G
|
D
|
S
|
40 |
TM1 | |||||||||
P
|
L
|
G
|
D
|
V
|
R
|
N
|
E
|
E
|
L
|
50 |
A
|
K
|
L
|
E
|
I
|
A
|
V
|
L
|
A
|
V
|
60 |
I
|
F
|
V
|
V
|
A
|
V
|
L
|
G
|
N
|
S
|
70 |
S
|
V
|
L
|
L
|
A
|
L
|
H
|
R
|
T
|
P
|
80 |
ICL1 | TM2 | ||||||||
R
|
K
|
T
|
S
|
R
|
M
|
H
|
L
|
F
|
I
|
90 |
R
|
H
|
L
|
S
|
L
|
A
|
D
|
L
|
A
|
V
|
100 |
A
|
F
|
F
|
Q
|
V
|
L
|
P
|
Q
|
L
|
C
|
110 |
ECL1 | |||||||||
W
|
D
|
I
|
T
|
Y
|
R
|
F
|
R
|
G
|
P
|
120 |
TM3 | |||||||||
D
|
W
|
L
|
C
|
R
|
V
|
V
|
K
|
H
|
L
|
130 |
Q
|
V
|
F
|
A
|
M
|
F
|
A
|
S
|
A
|
Y
|
140 |
M
|
L
|
V
|
V
|
M
|
T
|
A
|
D
|
R
|
Y
|
150 |
ICL2 | |||||||||
I
|
A
|
V
|
C
|
H
|
P
|
L
|
K
|
T
|
L
|
160 |
TM4 | |||||||||
Q
|
Q
|
P
|
A
|
R
|
R
|
S
|
R
|
L
|
M
|
170 |
I
|
A
|
T
|
S
|
W
|
V
|
L
|
S
|
F
|
I
|
180 |
L
|
S
|
T
|
P
|
Q
|
Y
|
F
|
I
|
F
|
S
|
190 |
ECL2 | |||||||||
V
|
I
|
E
|
I
|
E
|
V
|
N
|
N
|
G
|
T
|
200 |
K
|
T
|
Q
|
D
|
C
|
W
|
A
|
T
|
F
|
I
|
210 |
TM5 | |||||||||
Q
|
P
|
W
|
G
|
T
|
R
|
A
|
Y
|
V
|
T
|
220 |
W
|
M
|
T
|
S
|
G
|
V
|
F
|
V
|
A
|
P
|
230 |
V
|
V
|
V
|
L
|
G
|
T
|
C
|
Y
|
G
|
F
|
240 |
I
|
C
|
Y
|
H
|
I
|
W
|
R
|
N
|
I
|
R
|
250 |
ICL3 | |||||||||
G
|
K
|
T
|
A
|
S
|
S
|
R
|
H
|
S
|
K
|
260 |
G
|
D
|
K
|
G
|
S
|
G
|
E
|
A
|
V
|
G
|
270 |
P
|
F
|
H
|
K
|
G
|
L
|
L
|
V
|
T
|
P
|
280 |
TM6 | |||||||||
C
|
V
|
S
|
S
|
V
|
K
|
S
|
I
|
S
|
R
|
290 |
A
|
K
|
I
|
R
|
T
|
V
|
K
|
M
|
T
|
F
|
300 |
V
|
I
|
V
|
S
|
A
|
Y
|
I
|
L
|
C
|
W
|
310 |
A
|
P
|
F
|
F
|
I
|
V
|
Q
|
M
|
W
|
S
|
320 |
ECL3 | |||||||||
V
|
W
|
D
|
E
|
N
|
F
|
I
|
W
|
T
|
D
|
330 |
TM7 | |||||||||
S
|
E
|
N
|
P
|
S
|
I
|
T
|
I
|
T
|
A
|
340 |
L
|
L
|
A
|
S
|
L
|
N
|
S
|
C
|
C
|
N
|
350 |
H8 | |||||||||
P
|
W
|
I
|
Y
|
M
|
F
|
F
|
S
|
G
|
H
|
360 |
L
|
L
|
Q
|
D
|
C
|
V
|
Q
|
S
|
F
|
P
|
370 |
C-term | |||||||||
C
|
C
|
H
|
S
|
M
|
A
|
Q
|
K
|
F
|
A
|
380 |
K
|
D
|
D
|
S
|
D
|
S
|
M
|
S
|
R
|
R
|
390 |
Q
|
T
|
S
|
Y
|
S
|
N
|
N
|
R
|
S
|
P
|
400 |
T
|
N
|
S
|
T
|
G
|
M
|
W
|
K
|
D
|
S
|
410 |
P
|
K
|
S
|
S
|
K
|
S
|
I
|
R
|
F
|
I
|
420 |
P
|
V
|
S
|
T
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
oxytocin, vasopressin
STRUCTURE MODELS
No structure models available. Check the Archive on Structure models for earlier releases.
STRUCTURES
No structures available