P2Y13 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.0 Å

REFERENCE

PUBLICATION DATE

June 10, 2026

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

ADP - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

ADP, ATP



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Aromatic TM3 R 141 3x50 G.H5 Y 243 G.H5.23
Hydrophobic TM3 R 141 3x50 G.H5 Y 243 G.H5.23
Hydrophobic ICL2 P 148 - G.H5 I 235 G.H5.15
Hydrophobic ICL2 P 148 - G.H5 K 232 G.H5.12
Hydrophobic ICL2 N 151 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 N 151 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 L 149 - G.H5 F 228 G.H5.08
Van-der-waals ICL2 L 149 - G.H5 F 228 G.H5.08
Hydrophobic TM3 I 145 3x54 G.H5 L 236 G.H5.16
Polar TM3 K 144 3x53 G.H5 Y 243 G.H5.23
Van-der-waals TM3 K 144 3x53 G.H5 Y 243 G.H5.23
Hydrophobic ICL2 L 149 - G.H5 K 232 G.H5.12
Hydrophobic TM5 I 231 5x61 G.H5 L 245 G.H5.25
Hydrophobic ICL2 L 149 - G.H5 I 235 G.H5.15
Hydrophobic ICL2 R 150 - G.S3 V 79 G.S3.01
Hydrophobic ICL2 R 150 - G.H5 F 228 G.H5.08
Hydrophobic ICL3 V 235 - G.H5 L 240 G.H5.20
Hydrophobic TM3 R 141 3x50 G.H5 L 245 G.H5.25
Van-der-waals TM3 R 141 3x50 G.H5 L 245 G.H5.25
Hydrophobic ICL2 L 149 - G.S1 L 34 G.S1.02
Hydrophobic ICL2 R 150 - G.s2s3 D 77 G.s2s3.01
Hydrophobic ICL2 L 149 - G.S3 V 79 G.S3.01
Van-der-waals ICL2 L 149 - G.S3 V 79 G.S3.01