GPR35 (q33bm1_rat)
FAMILY
Class A (Rhodopsin) Orphan receptors Class A orphans GPR35
GENE
Gpr35 (GPR35)
ORGANISM
Rat (Rattus norvegicus)
ALT. NAMES
G protein-coupled receptor GPR35
SOURCE
TREMBL
SEQUENCE
N-term | |||||||||
M
|
N
|
N
|
T
|
N
|
C
|
S
|
I
|
L
|
P
|
10 |
TM1 | |||||||||
W
|
P
|
A
|
A
|
V
|
N
|
H
|
I
|
F
|
T
|
20 |
I
|
Y
|
L
|
V
|
L
|
L
|
L
|
V
|
L
|
G
|
30 |
L
|
L
|
L
|
N
|
G
|
L
|
A
|
L
|
W
|
V
|
40 |
ICL1 | |||||||||
F
|
C
|
Y
|
R
|
M
|
H
|
Q
|
W
|
T
|
E
|
50 |
TM2 | |||||||||
T
|
R
|
V
|
Y
|
M
|
T
|
N
|
L
|
A
|
V
|
60 |
A
|
D
|
V
|
C
|
L
|
L
|
C
|
S
|
L
|
P
|
70 |
ECL1 | |||||||||
F
|
V
|
L
|
Y
|
S
|
L
|
K
|
Y
|
S
|
T
|
80 |
TM3 | |||||||||
S
|
D
|
T
|
P
|
I
|
C
|
Q
|
L
|
S
|
Q
|
90 |
G
|
I
|
Y
|
L
|
V
|
N
|
R
|
Y
|
M
|
S
|
100 |
I
|
S
|
L
|
V
|
T
|
A
|
I
|
A
|
V
|
D
|
110 |
R
|
Y
|
V
|
A
|
V
|
R
|
H
|
P
|
L
|
R
|
120 |
ICL2 | TM4 | ||||||||
A
|
R
|
E
|
L
|
R
|
S
|
P
|
R
|
Q
|
A
|
130 |
G
|
A
|
V
|
C
|
V
|
A
|
L
|
W
|
V
|
I
|
140 |
V
|
V
|
T
|
S
|
L
|
V
|
L
|
R
|
W
|
R
|
150 |
ECL2 | |||||||||
L
|
G
|
I
|
Q
|
E
|
G
|
G
|
F
|
C
|
F
|
160 |
S
|
S
|
Q
|
N
|
R
|
Y
|
N
|
F
|
S
|
T
|
170 |
TM5 | |||||||||
T
|
A
|
F
|
S
|
L
|
L
|
G
|
F
|
Y
|
L
|
180 |
P
|
L
|
A
|
I
|
V
|
V
|
F
|
C
|
S
|
L
|
190 |
Q
|
V
|
V
|
T
|
A
|
L
|
A
|
R
|
R
|
P
|
200 |
ICL3 | TM6 | ||||||||
A
|
T
|
D
|
V
|
E
|
Q
|
V
|
E
|
A
|
T
|
210 |
Q
|
K
|
A
|
T
|
R
|
M
|
V
|
W
|
A
|
N
|
220 |
L
|
A
|
V
|
F
|
I
|
I
|
C
|
F
|
L
|
P
|
230 |
L
|
H
|
L
|
I
|
L
|
T
|
V
|
Q
|
V
|
S
|
240 |
ECL3 | TM7 | ||||||||
L
|
N
|
L
|
H
|
T
|
C
|
A
|
A
|
R
|
N
|
250 |
I
|
F
|
S
|
R
|
A
|
L
|
T
|
I
|
T
|
A
|
260 |
K
|
L
|
S
|
D
|
I
|
N
|
C
|
C
|
L
|
D
|
270 |
H8 | |||||||||
A
|
I
|
C
|
Y
|
Y
|
Y
|
M
|
A
|
K
|
E
|
280 |
F
|
Q
|
D
|
A
|
S
|
L
|
R
|
A
|
T
|
A
|
290 |
C-term | |||||||||
S
|
S
|
T
|
P
|
H
|
K
|
S
|
Q
|
D
|
T
|
300 |
Q
|
S
|
L
|
S
|
L
|
T
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
kynurenic acid
STRUCTURE MODELS
No structure models available. Check the Archive on Structure models for earlier releases.
STRUCTURES
No structures available