D3 receptor (drd3_human)
FAMILY
Class A (Rhodopsin) Aminergic receptors Dopamine receptors D3 receptor
GENE
DRD3
ORGANISM
Human (Homo sapiens)
ALT. NAMES
D(3) dopamine receptor, Dopamine D3 receptor
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
A
|
S
|
L
|
S
|
Q
|
L
|
S
|
G
|
H
|
10 |
L
|
N
|
Y
|
T
|
C
|
G
|
A
|
E
|
N
|
S
|
20 |
TM1 | |||||||||
T
|
G
|
A
|
S
|
Q
|
A
|
R
|
P
|
H
|
A
|
30 |
Y
|
Y
|
A
|
L
|
S
|
Y
|
C
|
A
|
L
|
I
|
40 |
L
|
A
|
I
|
V
|
F
|
G
|
N
|
G
|
L
|
V
|
50 |
C
|
M
|
A
|
V
|
L
|
K
|
E
|
R
|
A
|
L
|
60 |
ICL1 | TM2 | ||||||||
Q
|
T
|
T
|
T
|
N
|
Y
|
L
|
V
|
V
|
S
|
70 |
L
|
A
|
V
|
A
|
D
|
L
|
L
|
V
|
A
|
T
|
80 |
L
|
V
|
M
|
P
|
W
|
V
|
V
|
Y
|
L
|
E
|
90 |
ECL1 | |||||||||
V
|
T
|
G
|
G
|
V
|
W
|
N
|
F
|
S
|
R
|
100 |
TM3 | |||||||||
I
|
C
|
C
|
D
|
V
|
F
|
V
|
T
|
L
|
D
|
110 |
V
|
M
|
M
|
C
|
T
|
A
|
S
|
I
|
L
|
N
|
120 |
L
|
C
|
A
|
I
|
S
|
I
|
D
|
R
|
Y
|
T
|
130 |
ICL2 | |||||||||
A
|
V
|
V
|
M
|
P
|
V
|
H
|
Y
|
Q
|
H
|
140 |
TM4 | |||||||||
G
|
T
|
G
|
Q
|
S
|
S
|
C
|
R
|
R
|
V
|
150 |
A
|
L
|
M
|
I
|
T
|
A
|
V
|
W
|
V
|
L
|
160 |
A
|
F
|
A
|
V
|
S
|
C
|
P
|
L
|
L
|
F
|
170 |
ECL2 | |||||||||
G
|
F
|
N
|
T
|
T
|
G
|
D
|
P
|
T
|
V
|
180 |
TM5 | |||||||||
C
|
S
|
I
|
S
|
N
|
P
|
D
|
F
|
V
|
I
|
190 |
Y
|
S
|
S
|
V
|
V
|
S
|
F
|
Y
|
L
|
P
|
200 |
F
|
G
|
V
|
T
|
V
|
L
|
V
|
Y
|
A
|
R
|
210 |
I
|
Y
|
V
|
V
|
L
|
K
|
Q
|
R
|
R
|
R
|
220 |
ICL3 | |||||||||
K
|
R
|
I
|
L
|
T
|
R
|
Q
|
N
|
S
|
Q
|
230 |
C
|
N
|
S
|
V
|
R
|
P
|
G
|
F
|
P
|
Q
|
240 |
Q
|
T
|
L
|
S
|
P
|
D
|
P
|
A
|
H
|
L
|
250 |
E
|
L
|
K
|
R
|
Y
|
Y
|
S
|
I
|
C
|
Q
|
260 |
D
|
T
|
A
|
L
|
G
|
G
|
P
|
G
|
F
|
Q
|
270 |
E
|
R
|
G
|
G
|
E
|
L
|
K
|
R
|
E
|
E
|
280 |
K
|
T
|
R
|
N
|
S
|
L
|
S
|
P
|
T
|
I
|
290 |
A
|
P
|
K
|
L
|
S
|
L
|
E
|
V
|
R
|
K
|
300 |
L
|
S
|
N
|
G
|
R
|
L
|
S
|
T
|
S
|
L
|
310 |
TM6 | |||||||||
K
|
L
|
G
|
P
|
L
|
Q
|
P
|
R
|
G
|
V
|
320 |
P
|
L
|
R
|
E
|
K
|
K
|
A
|
T
|
Q
|
M
|
330 |
V
|
A
|
I
|
V
|
L
|
G
|
A
|
F
|
I
|
V
|
340 |
C
|
W
|
L
|
P
|
F
|
F
|
L
|
T
|
H
|
V
|
350 |
ECL3 | |||||||||
L
|
N
|
T
|
H
|
C
|
Q
|
T
|
C
|
H
|
V
|
360 |
TM7 | |||||||||
S
|
P
|
E
|
L
|
Y
|
S
|
A
|
T
|
T
|
W
|
370 |
L
|
G
|
Y
|
V
|
N
|
S
|
A
|
L
|
N
|
P
|
380 |
H8 | |||||||||
V
|
I
|
Y
|
T
|
T
|
F
|
N
|
I
|
E
|
F
|
390 |
R
|
K
|
A
|
F
|
L
|
K
|
I
|
L
|
S
|
C
|
400 |
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
dopamine
STRUCTURE MODELS
STRUCTURES
Found 4 structure(s) - view all details on the Structures page