D3 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.2 Å

REFERENCE

PUBLICATION DATE

May 20, 2026

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

quinpirole - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

dopamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Polar ICL2 H 140 34x55 G.h2s4 T 219 G.h2s4.05
Polar ICL2 Q 139 34x54 G.S1 E 33 G.S1.01
Hydrophobic TM6 V 331 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 331 6x37 G.H5 L 353 G.H5.25
Hydrophobic ICL2 Q 139 34x54 G.S1 V 34 G.S1.02
Polar TM3 R 128 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 128 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 P 135 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 135 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL2 H 140 34x55 G.H5 I 343 G.H5.15
Hydrophobic ICL2 H 140 34x55 G.H5 N 346 G.H5.18
Hydrophobic TM6 M 330 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 M 330 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM6 K 326 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 326 6x32 G.H5 F 354 G.H5.26
Polar ICL2 Y 138 34x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 Y 138 34x53 G.H5 C 351 G.H5.23
Van-der-waals ICL2 Y 138 34x53 G.H5 C 351 G.H5.23
Polar TM3 A 131 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 131 3x53 G.H5 N 347 G.H5.19
Polar ICL2 Y 138 34x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 Y 138 34x53 G.H5 N 347 G.H5.19
Van-der-waals ICL2 Y 138 34x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 131 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 131 3x53 G.H5 C 351 G.H5.23
Polar ICL2 P 135 34x50 G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 135 34x50 G.H5 N 347 G.H5.19
Hydrophobic TM4 Q 144 4x36 G.HN E 28 G.HN.52
Van-der-waals TM4 Q 144 4x36 G.HN E 28 G.HN.52
Hydrophobic TM3 R 128 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 128 3x50 G.H5 L 353 G.H5.25
Polar ICL2 T 142 34x57 G.H5 D 350 G.H5.22
Van-der-waals ICL2 T 142 34x57 G.H5 D 350 G.H5.22
Hydrophobic ICL2 G 141 34x56 G.H5 D 350 G.H5.22
Van-der-waals ICL2 G 141 34x56 G.H5 D 350 G.H5.22
Hydrophobic TM6 M 330 6x36 G.H5 G 352 G.H5.24
Van-der-waals TM6 M 330 6x36 G.H5 G 352 G.H5.24
Polar TM6 A 327 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 327 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 327 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 135 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 135 34x50 G.H5 I 344 G.H5.16
Hydrophobic ICL2 V 136 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM2 T 64 2x39 G.H5 C 351 G.H5.23
Polar ICL1 T 62 - G.H5 D 350 G.H5.22
Van-der-waals TM7 F 386 7x56 G.H5 F 354 G.H5.26
Hydrophobic H8 N 387 8x47 G.H5 G 352 G.H5.24
Polar ICL2 G 141 34x56 G.H5 N 347 G.H5.19
Van-der-waals ICL2 G 141 34x56 G.H5 N 347 G.H5.19
Hydrophobic ICL2 Q 139 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 Q 139 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 A 327 6x33 G.H5 L 348 G.H5.20
Van-der-waals TM6 A 327 6x33 G.H5 L 348 G.H5.20
Hydrophobic ICL2 Q 139 34x54 G.H5 I 343 G.H5.15
Van-der-waals ICL2 Q 139 34x54 G.H5 I 343 G.H5.15
Polar TM3 D 127 3x49 G.H5 C 351 G.H5.23
Polar ICL2 Q 139 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 Q 139 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 Q 139 34x54 G.hns1 A 31 G.hns1.02
Polar ICL2 H 140 34x55 G.H5 N 347 G.H5.19
Van-der-waals ICL2 H 140 34x55 G.H5 N 347 G.H5.19
Hydrophobic TM2 T 64 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 T 64 2x39 G.H5 D 350 G.H5.22