PDB
9R42
Resolution
3.2 Å
Released
May 20, 2026
Receptor
D3
Class
A
Species
Homo sapiens
Ligand
quinpirole
Function
Agonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
quinpirole D110 3.32x32 TM3 polar (charge-assisted hydrogen bond)
quinpirole V111 3.33x33 TM3 hydrophobic
quinpirole V111 3.33x33 TM3 Van der Waals
quinpirole C114 3.36x36 TM3 Van der Waals
quinpirole W342 6.48x48 TM6 hydrophobic
quinpirole W342 6.48x48 TM6 Van der Waals
quinpirole F345 6.51x51 TM6 aromatic (edge-to-face)
quinpirole F345 6.51x51 TM6 Van der Waals
quinpirole F346 6.52x52 TM6 Van der Waals
quinpirole F346 6.52x52 TM6 hydrophobic
quinpirole H349 6.55x55 TM6 Van der Waals
quinpirole H349 6.55x55 TM6 aromatic (face-to-edge)
quinpirole T369 7.39x38 TM7 Van der Waals
quinpirole Y373 7.43x42 TM7 Van der Waals
quinpirole Y373 7.43x42 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 R A L Q ICL1ECL1 G V W N F ECL1ICL2 P V H Y Q H G T G Q S ICL2ECL2 F N T T G D P T V C S I S ECL2ICL3 Q N S Q C N S V R P G F P Q Q T L S P D P A H L E L K R Y Y S I C Q D T A L G G P G F Q E R G G E L K R E E K T R N S L S P T I A P K L S L E V R K L S N G R L S T S L K L G P L Q P ICL3ECL3 Q T C H V ECL3N-term M A S L S Q L S G H L N Y T C G A E N S T G A S Q N-termC-term C C-term A R P H A Y Y A L S Y C A L I L A I V F G N G L V C M A V L K E T T T N Y L V V S L A V A D L L V A T L V M P W V V Y L E V T G S R I C C D V F V T L D V M M C T A S I L N L C A I S I D R Y T A V V M S C R R V A L M I T A V W V L A F A V S C P L L F G N P D F V I Y S S V V S F Y L P F G V T V L V Y A R I Y V V L K Q R R R K R I L T R R G V P L R E K K A T Q M V A I V L G A F I V C W L P F F L T H V L N T H C S P E L Y S A T T W L G Y V N S A L N P V I Y T T F N I E F L K F R K A I L S
Helix box plot — Download: PNG | SVG G N G F V I A L I L A C Y S L A Y Y A H 1 V S L A V A D L L V A L T V M P W V V Y L 2 A C L N L I S A T C M M V D L T V F V D 3 V A L M I T A V W V L A F A V S C P L 4 Y V L V T V G F P L Y F S V V S S Y I V F 5 A I V L G A F I V C W L P F F L T H V L 6 V P N L A S N V Y G L W T T A S Y L E 7

GPCRdb(A)
GPCRdb(A)
D3 receptor
TM3
3x32 3.32x32 D110
3x33 3.33x33 V111
3x36 3.36x36 C114
TM6
6x48 6.48x48 W342
6x51 6.51x51 F345
6x52 6.52x52 F346
6x55 6.55x55 H349
TM7
7x38 7.39x38 T369
7x42 7.43x42 Y373