A3 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.6 Å

REFERENCE

PUBLICATION DATE

Aug. 20, 2025

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

PHYSIOLOGICAL LIGANDS

adenosine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Polar ICL2 K 119 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 K 119 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 K 119 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 V 116 34x51 G.H5 T 340 G.H5.12
Hydrophobic TM3 R 111 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 V 116 34x51 G.S3 L 194 G.S3.01
Ionic TM4 H 124 4x39 G.HN E 28 G.HN.52
Hydrophobic TM4 H 124 4x39 G.HN E 28 G.HN.52
Hydrophobic H8 I 286 8x47 G.H5 C 351 G.H5.23
Polar TM3 R 111 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 R 111 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 R 111 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 T 115 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM3 V 112 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM2 T 47 2x39 G.H5 D 350 G.H5.22
Polar ICL1 Q 44 12x51 G.HN R 24 G.HN.48
Hydrophobic ICL1 Q 44 12x51 G.HN R 24 G.HN.48
Van-der-waals ICL1 Q 44 12x51 G.HN R 24 G.HN.48
Van-der-waals H8 I 286 8x47 G.H5 D 350 G.H5.22
Hydrophobic TM6 T 228 6x33 G.H5 F 354 G.H5.26
Hydrophobic ICL2 V 116 34x51 G.H5 I 343 G.H5.15
Hydrophobic ICL2 T 115 34x50 G.H5 T 340 G.H5.12
Polar TM6 S 231 6x36 G.H5 G 352 G.H5.24
Hydrophobic TM6 L 232 6x37 G.H5 L 353 G.H5.25
Hydrophobic ICL2 Y 118 34x53 G.H5 N 347 G.H5.19
Van-der-waals ICL2 Y 118 34x53 G.H5 N 347 G.H5.19
Ionic H8 K 288 8x49 G.H5 D 350 G.H5.22
Polar H8 K 288 8x49 G.H5 D 350 G.H5.22
Hydrophobic H8 K 288 8x49 G.H5 D 350 G.H5.22
Van-der-waals H8 K 288 8x49 G.H5 D 350 G.H5.22
Ionic ICL2 R 120 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 R 120 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM5 I 204 5x65 G.H5 F 354 G.H5.26
Polar TM3 R 108 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 108 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 V 116 34x51 G.H5 F 336 G.H5.08
Hydrophobic TM3 R 108 3x50 G.H5 L 353 G.H5.25