PDB
9EBH
Resolution
3.6 Å
Released
Aug. 20, 2025
Receptor
A3
Class
A
Species
Homo sapiens
Ligand
adenosine
Function
Agonist
Reference
10.1038/S41467-025-62872-X

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Ligand Amino Acid Generic Number Segment Interaction Type
adenosine F168 45.52x52 ECL2 aromatic (face-to-face)
adenosine L246 6.51x51 TM6 hydrophobic
adenosine N250 6.55x55 TM6 polar (hydrogen bond)
adenosine L264 7.35x34 TM7 Van der Waals
adenosine I268 7.39x38 TM7 Van der Waals
adenosine I268 7.39x38 TM7 hydrophobic
adenosine S271 7.42x41 TM7 polar (hydrogen bond)
adenosine S271 7.42x41 TM7 Van der Waals
adenosine H272 7.43x42 TM7 polar (hydrogen bond)
adenosine H272 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 P S L Q ICL1ECL1 I T I ECL1ICL2 T V R Y K R V T ICL2ECL2 W N M K L T S E Y H R N V T F L S C Q F V S V M ECL2ICL3 S N S K ICL3ECL3 G E V ECL3N-term M P N N S T A L N-termC-term L D T S I E K N S E C-term S L A N V T Y I T M E I F I G L C A I V G N V L V I C V V K L N T T T F Y F I V S L A L A D I A V G V L V M P L A I V V S L G H F Y S C L F M T C L L L I F T H A S I M S L L A I A V D R Y L R V K L T H R R I W L A L G L C W L V S F L V G L T P M F G R M D Y M V Y F S F L T W I F I P L V V M C A I Y L D I F Y I I R N K L S L N L E T G A F Y G R E F K T A K S L F L V L F L F A L S W L P L S I I N C I I Y F N P Q L V L Y M G I L L S H A N S M M N P I V Y A Y K I K K Y L L C V V D S F K E T I L K A C H P S
Helix box plot — Download: PNG | SVG V N G V I A C L G I F I E M T I Y T V N 1 V S L A L A D I A V G L V V M P L A I V V 2 A L L S M I S A H T F I L L L C T M F L 3 I W L A L G L C W L V S F L V G L T P M 4 Y I A C M V V L P I F I W T L F S F Y V M Y 5 F L V L F L F A L S W L P L S I I N C I 6 I P N M M S N A H S L L I G M Y L V L 7

GPCRdb(A)
GPCRdb(A)
A3 receptor
ECL2
45x52 45.52x52 F168
TM6
6x51 6.51x51 L246
6x55 6.55x55 N250
TM7
7x34 7.35x34 L264
7x38 7.39x38 I268
7x41 7.42x41 S271
7x42 7.43x42 H272