α1D-adrenoceptor (ada1d_human)
FAMILY
Class A (Rhodopsin) Aminergic receptors Adrenoceptors α1D-adrenoceptor
GENE
ADRA1D (ADRA1A)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Alpha-1D adrenergic receptor, Alpha-1A adrenergic receptor, Alpha-1D adrenoreceptor, Alpha-1D adrenoceptor, Alpha-adrenergic receptor 1a
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
T
|
F
|
R
|
D
|
L
|
L
|
S
|
V
|
S
|
10 |
F
|
E
|
G
|
P
|
R
|
P
|
D
|
S
|
S
|
A
|
20 |
G
|
G
|
S
|
S
|
A
|
G
|
G
|
G
|
G
|
G
|
30 |
S
|
A
|
G
|
G
|
A
|
A
|
P
|
S
|
E
|
G
|
40 |
P
|
A
|
V
|
G
|
G
|
V
|
P
|
G
|
G
|
A
|
50 |
G
|
G
|
G
|
G
|
G
|
V
|
V
|
G
|
A
|
G
|
60 |
S
|
G
|
E
|
D
|
N
|
R
|
S
|
S
|
A
|
G
|
70 |
E
|
P
|
G
|
S
|
A
|
G
|
A
|
G
|
G
|
D
|
80 |
V
|
N
|
G
|
T
|
A
|
A
|
V
|
G
|
G
|
L
|
90 |
TM1 | |||||||||
V
|
V
|
S
|
A
|
Q
|
G
|
V
|
G
|
V
|
G
|
100 |
V
|
F
|
L
|
A
|
A
|
F
|
I
|
L
|
M
|
A
|
110 |
V
|
A
|
G
|
N
|
L
|
L
|
V
|
I
|
L
|
S
|
120 |
ICL1 | |||||||||
V
|
A
|
C
|
N
|
R
|
H
|
L
|
Q
|
T
|
V
|
130 |
TM2 | |||||||||
T
|
N
|
Y
|
F
|
I
|
V
|
N
|
L
|
A
|
V
|
140 |
A
|
D
|
L
|
L
|
L
|
S
|
A
|
T
|
V
|
L
|
150 |
P
|
F
|
S
|
A
|
T
|
M
|
E
|
V
|
L
|
G
|
160 |
ECL1 | TM3 | ||||||||
F
|
W
|
A
|
F
|
G
|
R
|
A
|
F
|
C
|
D
|
170 |
V
|
W
|
A
|
A
|
V
|
D
|
V
|
L
|
C
|
C
|
180 |
T
|
A
|
S
|
I
|
L
|
S
|
L
|
C
|
T
|
I
|
190 |
S
|
V
|
D
|
R
|
Y
|
V
|
G
|
V
|
R
|
H
|
200 |
ICL2 | |||||||||
S
|
L
|
K
|
Y
|
P
|
A
|
I
|
M
|
T
|
E
|
210 |
TM4 | |||||||||
R
|
K
|
A
|
A
|
A
|
I
|
L
|
A
|
L
|
L
|
220 |
W
|
V
|
V
|
A
|
L
|
V
|
V
|
S
|
V
|
G
|
230 |
ECL2 | |||||||||
P
|
L
|
L
|
G
|
W
|
K
|
E
|
P
|
V
|
P
|
240 |
P
|
D
|
E
|
R
|
F
|
C
|
G
|
I
|
T
|
E
|
250 |
TM5 | |||||||||
E
|
A
|
G
|
Y
|
A
|
V
|
F
|
S
|
S
|
V
|
260 |
C
|
S
|
F
|
Y
|
L
|
P
|
M
|
A
|
V
|
I
|
270 |
V
|
V
|
M
|
Y
|
C
|
R
|
V
|
Y
|
V
|
V
|
280 |
A
|
R
|
S
|
T
|
T
|
R
|
S
|
L
|
E
|
A
|
290 |
ICL3 | |||||||||
G
|
V
|
K
|
R
|
E
|
R
|
G
|
K
|
A
|
S
|
300 |
E
|
V
|
V
|
L
|
R
|
I
|
H
|
C
|
R
|
G
|
310 |
A
|
A
|
T
|
G
|
A
|
D
|
G
|
A
|
H
|
G
|
320 |
M
|
R
|
S
|
A
|
K
|
G
|
H
|
T
|
F
|
R
|
330 |
TM6 | |||||||||
S
|
S
|
L
|
S
|
V
|
R
|
L
|
L
|
K
|
F
|
340 |
S
|
R
|
E
|
K
|
K
|
A
|
A
|
K
|
T
|
L
|
350 |
A
|
I
|
V
|
V
|
G
|
V
|
F
|
V
|
L
|
C
|
360 |
W
|
F
|
P
|
F
|
F
|
F
|
V
|
L
|
P
|
L
|
370 |
ECL3 | |||||||||
G
|
S
|
L
|
F
|
P
|
Q
|
L
|
K
|
P
|
S
|
380 |
TM7 | |||||||||
E
|
G
|
V
|
F
|
K
|
V
|
I
|
F
|
W
|
L
|
390 |
G
|
Y
|
F
|
N
|
S
|
C
|
V
|
N
|
P
|
L
|
400 |
H8 | |||||||||
I
|
Y
|
P
|
C
|
S
|
S
|
R
|
E
|
F
|
K
|
410 |
R
|
A
|
F
|
L
|
R
|
L
|
L
|
R
|
C
|
Q
|
420 |
C-term | |||||||||
C
|
R
|
R
|
R
|
R
|
R
|
R
|
R
|
P
|
L
|
430 |
W
|
R
|
V
|
Y
|
G
|
H
|
H
|
W
|
R
|
A
|
440 |
S
|
T
|
S
|
G
|
L
|
R
|
Q
|
D
|
C
|
A
|
450 |
P
|
S
|
S
|
G
|
D
|
A
|
P
|
P
|
G
|
A
|
460 |
P
|
L
|
A
|
L
|
T
|
A
|
L
|
P
|
D
|
P
|
470 |
D
|
P
|
E
|
P
|
P
|
G
|
T
|
P
|
E
|
M
|
480 |
Q
|
A
|
P
|
V
|
A
|
S
|
R
|
R
|
K
|
P
|
490 |
P
|
S
|
A
|
F
|
R
|
E
|
W
|
R
|
L
|
L
|
500 |
G
|
P
|
F
|
R
|
R
|
P
|
T
|
T
|
Q
|
L
|
510 |
R
|
A
|
K
|
V
|
S
|
S
|
L
|
S
|
H
|
K
|
520 |
I
|
R
|
A
|
G
|
G
|
A
|
Q
|
R
|
A
|
E
|
530 |
A
|
A
|
C
|
A
|
Q
|
R
|
S
|
E
|
V
|
E
|
540 |
A
|
V
|
S
|
L
|
G
|
V
|
P
|
H
|
E
|
V
|
550 |
A
|
E
|
G
|
A
|
T
|
C
|
Q
|
A
|
Y
|
E
|
560 |
L
|
A
|
D
|
Y
|
S
|
N
|
L
|
R
|
E
|
T
|
570 |
D
|
I
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
(-)-noradrenaline, (-)-adrenaline
STRUCTURE MODELS
STRUCTURES
No structures available