5-HT2A receptor (5ht2a_human)
FAMILY
Class A (Rhodopsin) Aminergic receptors 5-Hydroxytryptamine receptors 5-HT2A receptor
GENE
HTR2A (HTR2)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
5-hydroxytryptamine receptor 2A, 5-HT-2, 5-HT-2A, Serotonin receptor 2A
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
D
|
I
|
L
|
C
|
E
|
E
|
N
|
T
|
S
|
10 |
L
|
S
|
S
|
T
|
T
|
N
|
S
|
L
|
M
|
Q
|
20 |
L
|
N
|
D
|
D
|
T
|
R
|
L
|
Y
|
S
|
N
|
30 |
D
|
F
|
N
|
S
|
G
|
E
|
A
|
N
|
T
|
S
|
40 |
D
|
A
|
F
|
N
|
W
|
T
|
V
|
D
|
S
|
E
|
50 |
N
|
R
|
T
|
N
|
L
|
S
|
C
|
E
|
G
|
C
|
60 |
L
|
S
|
P
|
S
|
C
|
L
|
S
|
L
|
L
|
H
|
70 |
TM1 | |||||||||
L
|
Q
|
E
|
K
|
N
|
W
|
S
|
A
|
L
|
L
|
80 |
T
|
A
|
V
|
V
|
I
|
I
|
L
|
T
|
I
|
A
|
90 |
G
|
N
|
I
|
L
|
V
|
I
|
M
|
A
|
V
|
S
|
100 |
ICL1 | TM2 | ||||||||
L
|
E
|
K
|
K
|
L
|
Q
|
N
|
A
|
T
|
N
|
110 |
Y
|
F
|
L
|
M
|
S
|
L
|
A
|
I
|
A
|
D
|
120 |
M
|
L
|
L
|
G
|
F
|
L
|
V
|
M
|
P
|
V
|
130 |
S
|
M
|
L
|
T
|
I
|
L
|
Y
|
G
|
Y
|
R
|
140 |
ECL1 | TM3 | ||||||||
W
|
P
|
L
|
P
|
S
|
K
|
L
|
C
|
A
|
V
|
150 |
W
|
I
|
Y
|
L
|
D
|
V
|
L
|
F
|
S
|
T
|
160 |
A
|
S
|
I
|
M
|
H
|
L
|
C
|
A
|
I
|
S
|
170 |
L
|
D
|
R
|
Y
|
V
|
A
|
I
|
Q
|
N
|
P
|
180 |
ICL2 | TM4 | ||||||||
I
|
H
|
H
|
S
|
R
|
F
|
N
|
S
|
R
|
T
|
190 |
K
|
A
|
F
|
L
|
K
|
I
|
I
|
A
|
V
|
W
|
200 |
T
|
I
|
S
|
V
|
G
|
I
|
S
|
M
|
P
|
I
|
210 |
P
|
V
|
F
|
G
|
L
|
Q
|
D
|
D
|
S
|
K
|
220 |
ECL2 | |||||||||
V
|
F
|
K
|
E
|
G
|
S
|
C
|
L
|
L
|
A
|
230 |
TM5 | |||||||||
D
|
D
|
N
|
F
|
V
|
L
|
I
|
G
|
S
|
F
|
240 |
V
|
S
|
F
|
F
|
I
|
P
|
L
|
T
|
I
|
M
|
250 |
V
|
I
|
T
|
Y
|
F
|
L
|
T
|
I
|
K
|
S
|
260 |
L
|
Q
|
K
|
E
|
A
|
T
|
L
|
C
|
V
|
S
|
270 |
ICL3 | |||||||||
D
|
L
|
G
|
T
|
R
|
A
|
K
|
L
|
A
|
S
|
280 |
F
|
S
|
F
|
L
|
P
|
Q
|
S
|
S
|
L
|
S
|
290 |
S
|
E
|
K
|
L
|
F
|
Q
|
R
|
S
|
I
|
H
|
300 |
R
|
E
|
P
|
G
|
S
|
Y
|
T
|
G
|
R
|
R
|
310 |
TM6 | |||||||||
T
|
M
|
Q
|
S
|
I
|
S
|
N
|
E
|
Q
|
K
|
320 |
A
|
C
|
K
|
V
|
L
|
G
|
I
|
V
|
F
|
F
|
330 |
L
|
F
|
V
|
V
|
M
|
W
|
C
|
P
|
F
|
F
|
340 |
I
|
T
|
N
|
I
|
M
|
A
|
V
|
I
|
C
|
K
|
350 |
ECL3 | TM7 | ||||||||
E
|
S
|
C
|
N
|
E
|
D
|
V
|
I
|
G
|
A
|
360 |
L
|
L
|
N
|
V
|
F
|
V
|
W
|
I
|
G
|
Y
|
370 |
L
|
S
|
S
|
A
|
V
|
N
|
P
|
L
|
V
|
Y
|
380 |
H8 | |||||||||
T
|
L
|
F
|
N
|
K
|
T
|
Y
|
R
|
S
|
A
|
390 |
F
|
S
|
R
|
Y
|
I
|
Q
|
C
|
Q
|
Y
|
K
|
400 |
C-term | |||||||||
E
|
N
|
K
|
K
|
P
|
L
|
Q
|
L
|
I
|
L
|
410 |
V
|
N
|
T
|
I
|
P
|
A
|
L
|
A
|
Y
|
K
|
420 |
S
|
S
|
Q
|
L
|
Q
|
M
|
G
|
Q
|
K
|
K
|
430 |
N
|
S
|
K
|
Q
|
D
|
A
|
K
|
T
|
T
|
D
|
440 |
N
|
D
|
C
|
S
|
M
|
V
|
A
|
L
|
G
|
K
|
450 |
Q
|
H
|
S
|
E
|
E
|
A
|
S
|
K
|
D
|
N
|
460 |
S
|
D
|
G
|
V
|
N
|
E
|
K
|
V
|
S
|
C
|
470 |
V
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
5-hydroxytryptamine, tryptamine