5-HT2A receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9ARY

RESOLUTION

3.3 Å

REFERENCE

10.1038/S41467-025-57956-7

PUBLICATION DATE

April 2, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

32 interactions (Click to see)

LIGANDS

5-hydroxytryptamine - Agonist pubchem gtoplig chembl_ligand drugbank

PHYSIOLOGICAL LIGANDS

tryptamine, 5-hydroxytryptamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM7 F 383 7x56 G.H5 N 244 G.H5.24
Van-der-waals TM7 F 383 7x56 G.H5 N 244 G.H5.24
Hydrophobic TM3 I 177 3x54 G.H5 L 236 G.H5.16
Van-der-waals TM3 I 177 3x54 G.H5 L 236 G.H5.16
Polar TM3 R 173 3x50 G.H5 Y 243 G.H5.23
Hydrophobic TM3 R 173 3x50 G.H5 Y 243 G.H5.23
Van-der-waals TM3 R 173 3x50 G.H5 Y 243 G.H5.23
Hydrophobic ICL2 I 181 34x51 G.H5 I 235 G.H5.15
Hydrophobic ICL2 P 180 34x50 G.H5 L 236 G.H5.16
Van-der-waals ICL2 P 180 34x50 G.H5 L 236 G.H5.16
Hydrophobic TM6 A 321 6x33 G.H5 L 240 G.H5.20
Hydrophobic TM6 N 317 6x29 G.H5 V 246 G.H5.26
Van-der-waals TM6 N 317 6x29 G.H5 V 246 G.H5.26
Hydrophobic TM3 I 177 3x54 G.H5 L 245 G.H5.25
Polar ICL2 P 180 34x50 G.H5 N 239 G.H5.19
Hydrophobic TM3 R 173 3x50 G.H5 L 245 G.H5.25
Van-der-waals TM3 R 173 3x50 G.H5 L 245 G.H5.25
Hydrophobic ICL2 F 186 34x56 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 F 186 34x56 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 P 180 34x50 G.H5 K 232 G.H5.12
Hydrophobic ICL2 I 181 34x51 G.S3 V 79 G.S3.01
Van-der-waals TM7 F 383 7x56 G.H5 V 246 G.H5.26
Polar H8 N 384 8x47 G.H5 N 244 G.H5.24
Hydrophobic H8 N 384 8x47 G.H5 N 244 G.H5.24
Van-der-waals H8 N 384 8x47 G.H5 N 244 G.H5.24
Hydrophobic TM6 E 318 6x30 G.H5 L 240 G.H5.20
Polar ICL2 R 185 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 R 185 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 185 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 N 317 6x29 G.H5 Q 237 G.H5.17
Hydrophobic ICL2 S 184 34x54 G.H5 I 235 G.H5.15
Van-der-waals ICL2 S 184 34x54 G.H5 I 235 G.H5.15
Polar TM3 A 176 3x53 G.H5 N 239 G.H5.19
Hydrophobic TM3 A 176 3x53 G.H5 N 239 G.H5.19
Van-der-waals TM3 A 176 3x53 G.H5 N 239 G.H5.19
Hydrophobic TM2 T 109 2x39 G.H5 Y 243 G.H5.23
Van-der-waals TM2 T 109 2x39 G.H5 Y 243 G.H5.23
Polar ICL2 S 184 34x54 G.H5 N 239 G.H5.19
Hydrophobic TM6 Q 313 6x25 G.h4s6 I 210 G.h4s6.20
Van-der-waals TM6 Q 313 6x25 G.h4s6 I 210 G.h4s6.20
Hydrophobic TM6 N 317 6x29 G.H5 L 240 G.H5.20
Van-der-waals TM6 K 320 6x32 G.H5 L 245 G.H5.25
Polar TM6 S 314 6x26 G.H5 Q 237 G.H5.17
Hydrophobic TM6 S 314 6x26 G.H5 Q 237 G.H5.17
Van-der-waals TM6 S 314 6x26 G.H5 Q 237 G.H5.17
Polar ICL2 R 185 34x55 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 R 185 34x55 G.hns1 R 31 G.hns1.02
Polar TM6 S 314 6x26 G.H5 D 233 G.H5.13
Hydrophobic TM6 S 314 6x26 G.H5 D 233 G.H5.13
Hydrophobic ICL2 P 180 34x50 G.H5 I 235 G.H5.15
Van-der-waals ICL2 P 180 34x50 G.H5 I 235 G.H5.15
Polar TM3 D 172 3x49 G.H5 Y 243 G.H5.23
Hydrophobic TM3 D 172 3x49 G.H5 Y 243 G.H5.23
Van-der-waals TM3 D 172 3x49 G.H5 Y 243 G.H5.23
Hydrophobic TM6 V 324 6x36 G.H5 L 245 G.H5.25
Hydrophobic TM3 I 177 3x54 G.H5 L 240 G.H5.20
Hydrophobic TM3 A 176 3x53 G.H5 Y 243 G.H5.23
Hydrophobic ICL2 R 185 34x55 G.S3 V 79 G.S3.01
Van-der-waals ICL2 R 185 34x55 G.S3 V 79 G.S3.01
Polar TM6 A 321 6x33 G.H5 L 245 G.H5.25
Hydrophobic TM6 A 321 6x33 G.H5 L 245 G.H5.25
Van-der-waals TM6 A 321 6x33 G.H5 L 245 G.H5.25
Hydrophobic ICL2 I 181 34x51 G.H5 F 228 G.H5.08
Van-der-waals ICL2 I 181 34x51 G.H5 F 228 G.H5.08
Polar TM7 Y 380 7x53 G.H5 N 244 G.H5.24
Van-der-waals TM7 Y 380 7x53 G.H5 N 244 G.H5.24
Hydrophobic ICL2 I 181 34x51 G.H5 K 232 G.H5.12