PDB
9ARY
Resolution
3.3 Å
Released
April 2, 2025
Receptor
5-HT2A
Class
A
Species
Homo sapiens
Ligand
5-hydroxytryptamine
Function
Agonist
Reference
10.1038/S41467-025-57956-7

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Ligand Amino Acid Generic Number Segment Interaction Type
5-hydroxytryptamine D155 3.32x32 TM3 polar (charge-assisted hydrogen bond)
5-hydroxytryptamine V156 3.33x33 TM3 hydrophobic
5-hydroxytryptamine V156 3.33x33 TM3 Van der Waals
5-hydroxytryptamine S159 3.36x36 TM3 Van der Waals
5-hydroxytryptamine T160 3.37x37 TM3 polar (hydrogen bond)
5-hydroxytryptamine T160 3.37x37 TM3 Van der Waals
5-hydroxytryptamine V235 5.39x40 TM5 Van der Waals
5-hydroxytryptamine G238 5.42x43 TM5 Van der Waals
5-hydroxytryptamine S239 5.43x44 TM5 Van der Waals
5-hydroxytryptamine S242 5.46x461 TM5 polar (hydrogen bond)
5-hydroxytryptamine S242 5.46x461 TM5 Van der Waals
5-hydroxytryptamine F339 6.51x51 TM6 Van der Waals
5-hydroxytryptamine F339 6.51x51 TM6 hydrophobic
5-hydroxytryptamine F340 6.52x52 TM6 aromatic (edge-to-face)
5-hydroxytryptamine F340 6.52x52 TM6 Van der Waals
5-hydroxytryptamine N343 6.55x55 TM6 polar (hydrogen bond)
5-hydroxytryptamine N343 6.55x55 TM6 Van der Waals

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ICL1 K K L Q ICL1ECL1 Y R W P L ECL1ICL2 P I H H S R F N ICL2ECL2 D S K V F K E G S C L L A ECL2ICL3 G T R A K L A S F S F L P Q S S L S S E K L F Q R S I H R E P G S Y T G R R T ICL3ECL3 K E S C ECL3N-term M D I L C E E N T S L S S T T N S L M Q L N D D T R L Y S N D F N S G E A N T S D A F N W T V D S E N R T N L S C E G C L S P S C L S L N-termC-term Q Y K E N K K P L Q L I L V N T I P A L A Y K S S Q L Q M G Q K K N S K Q D A K T T D N D C S M V A L G K Q H S E E A S K D N S D G V N E K V S C V C-term L H L Q E K N W S A L L T A V V I I L T I A G N I L V I M A V S L E N A T N Y F L M S L A I A D M L L G F L V M P V S M L T I L Y G P S K L C A V W I Y L D V L F S T A S I M H L C A I S L D R Y V A I Q N S R T K A F L K I I A V W T I S V G I S M P I P V F G L Q D D D N F V L I G S F V S F F I P L T I M V I T Y F L T I K S L Q K E A T L C V S D L M Q S I S N E Q K A C K V L G I V F F L F V V M W C P F F I T N I M A V I C N E D V I G A L L N V F V W I G Y L S S A V N P L V Y T L F N K T F S R Y R S A Y I Q C
Helix box plot — Download: PNG | SVG I N G A I T L I I V V A T L L A S W N K 1 M S L A I A D M L L G L F V M P V S M L T 2 A C L H M I S A T S F L V D L Y I W V A 3 A F L K I I A V W T I S V G I S M P I 4 Y T I V M I T L P I F F S V F S G I L V F 5 G I V F F L F V V M W C P F F I T N I M 6 L P N V A S S L Y G I W V F V N L L A 7

GPCRdb(A)
GPCRdb(A)
5-HT2A receptor
TM3
3x32 3.32x32 D155
3x33 3.33x33 V156
3x36 3.36x36 S159
3x37 3.37x37 T160
TM5
5x40 5.39x40 V235
5x43 5.42x43 G238
5x44 5.43x44 S239
5x461 5.46x461 S242
TM6
6x51 6.51x51 F339
6x52 6.52x52 F340
6x55 6.55x55 N343