CCR4 (ccr4_human)
FAMILY
Class A (Rhodopsin) Protein receptors Chemokine receptors CCR4
GENE
CCR4 (CMKBR4)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
C-C chemokine receptor type 4, C-C CKR-4, CC-CKR-4, CCR-4, CCR4, K5-5, CD194
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
N
|
P
|
T
|
D
|
I
|
A
|
D
|
T
|
T
|
10 |
L
|
D
|
E
|
S
|
I
|
Y
|
S
|
N
|
Y
|
Y
|
20 |
L
|
Y
|
E
|
S
|
I
|
P
|
K
|
P
|
C
|
T
|
30 |
TM1 | |||||||||
K
|
E
|
G
|
I
|
K
|
A
|
F
|
G
|
E
|
L
|
40 |
F
|
L
|
P
|
P
|
L
|
Y
|
S
|
L
|
V
|
F
|
50 |
V
|
F
|
G
|
L
|
L
|
G
|
N
|
S
|
V
|
V
|
60 |
V
|
L
|
V
|
L
|
F
|
K
|
Y
|
K
|
R
|
L
|
70 |
ICL1 | TM2 | ||||||||
R
|
S
|
M
|
T
|
D
|
V
|
Y
|
L
|
L
|
N
|
80 |
L
|
A
|
I
|
S
|
D
|
L
|
L
|
F
|
V
|
F
|
90 |
S
|
L
|
P
|
F
|
W
|
G
|
Y
|
Y
|
A
|
A
|
100 |
ECL1 | TM3 | ||||||||
D
|
Q
|
W
|
V
|
F
|
G
|
L
|
G
|
L
|
C
|
110 |
K
|
M
|
I
|
S
|
W
|
M
|
Y
|
L
|
V
|
G
|
120 |
F
|
Y
|
S
|
G
|
I
|
F
|
F
|
V
|
M
|
L
|
130 |
M
|
S
|
I
|
D
|
R
|
Y
|
L
|
A
|
I
|
V
|
140 |
ICL2 | |||||||||
H
|
A
|
V
|
F
|
S
|
L
|
R
|
A
|
R
|
T
|
150 |
TM4 | |||||||||
L
|
T
|
Y
|
G
|
V
|
I
|
T
|
S
|
L
|
A
|
160 |
T
|
W
|
S
|
V
|
A
|
V
|
F
|
A
|
S
|
L
|
170 |
ECL2 | |||||||||
P
|
G
|
F
|
L
|
F
|
S
|
T
|
C
|
Y
|
T
|
180 |
E
|
R
|
N
|
H
|
T
|
Y
|
C
|
K
|
T
|
K
|
190 |
TM5 | |||||||||
Y
|
S
|
L
|
N
|
S
|
T
|
T
|
W
|
K
|
V
|
200 |
L
|
S
|
S
|
L
|
E
|
I
|
N
|
I
|
L
|
G
|
210 |
L
|
V
|
I
|
P
|
L
|
G
|
I
|
M
|
L
|
F
|
220 |
C
|
Y
|
S
|
M
|
I
|
I
|
R
|
T
|
L
|
Q
|
230 |
ICL3 | TM6 | ||||||||
H
|
C
|
K
|
N
|
E
|
K
|
K
|
N
|
K
|
A
|
240 |
V
|
K
|
M
|
I
|
F
|
A
|
V
|
V
|
V
|
L
|
250 |
F
|
L
|
G
|
F
|
W
|
T
|
P
|
Y
|
N
|
I
|
260 |
V
|
L
|
F
|
L
|
E
|
T
|
L
|
V
|
E
|
L
|
270 |
ECL3 | TM7 | ||||||||
E
|
V
|
L
|
Q
|
D
|
C
|
T
|
F
|
E
|
R
|
280 |
Y
|
L
|
D
|
Y
|
A
|
I
|
Q
|
A
|
T
|
E
|
290 |
T
|
L
|
A
|
F
|
V
|
H
|
C
|
C
|
L
|
N
|
300 |
H8 | |||||||||
P
|
I
|
I
|
Y
|
F
|
F
|
L
|
G
|
E
|
K
|
310 |
F
|
R
|
K
|
Y
|
I
|
L
|
Q
|
L
|
F
|
K
|
320 |
C-term | |||||||||
T
|
C
|
R
|
G
|
L
|
F
|
V
|
L
|
C
|
Q
|
330 |
Y
|
C
|
G
|
L
|
L
|
Q
|
I
|
Y
|
S
|
A
|
340 |
D
|
T
|
P
|
S
|
S
|
S
|
Y
|
T
|
Q
|
S
|
350 |
T
|
M
|
D
|
H
|
D
|
L
|
H
|
D
|
A
|
L
|
360 |
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
CCL22, CCL17
STRUCTURE MODELS
STRUCTURES
No structures available