S1P1 receptor (s1pr1_human)

FAMILY

Class A (Rhodopsin) Lipid receptors Lysophospholipid (S1P) receptors S1P1 receptor

GENE

S1PR1 (CHEDG1, EDG1)

ORGANISM

Human (Homo sapiens)

ALT. NAMES

Sphingosine 1-phosphate receptor 1, S1P receptor 1, S1P1, Endothelial differentiation G-protein coupled receptor 1, Sphingosine 1-phosphate receptor Edg-1, S1P receptor Edg-1, CD363

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
G
P
T
S
V
P
L
V
K
10
                   
A
H
R
S
S
V
S
D
Y
V
20
                   
N
Y
D
I
I
V
R
H
Y
N
30
                   
Y
T
G
K
L
N
I
S
A
D
40
  TM1            
K
E
N
S
I
K
L
T
S
V
50
                   
V
F
I
L
I
C
C
F
I
I
60
                   
L
E
N
I
F
V
L
L
T
I
70
      ICL1 TM2
W
K
T
K
K
F
H
R
P
M
80
                   
Y
Y
F
I
G
N
L
A
L
S
90
                   
D
L
L
A
G
V
A
Y
T
A
100
          ECL1  
N
L
L
L
S
G
A
T
T
Y
110
    TM3          
K
L
T
P
A
Q
W
F
L
R
120
                   
E
G
S
M
F
V
A
L
S
A
130
                   
S
V
F
S
L
L
A
I
A
I
140
                   
E
R
Y
I
T
M
L
K
M
K
150
ICL2   TM4    
L
H
N
G
S
N
N
F
R
L
160
                   
F
L
L
I
S
A
C
W
V
I
170
                   
S
L
I
L
G
G
L
P
I
M
180
  ECL2          
G
W
N
C
I
S
A
L
S
S
190
                   
C
S
T
V
L
P
L
Y
H
K
200
TM5              
H
Y
I
L
F
C
T
T
V
F
210
                   
T
L
L
L
L
S
I
V
I
L
220
                   
Y
C
R
I
Y
S
L
V
R
T
230
            ICL3
R
S
R
R
L
T
F
R
K
N
240
        TM6      
I
S
K
A
S
R
S
S
E
K
250
                   
S
L
A
L
L
K
T
V
I
I
260
                   
V
L
S
V
F
I
A
C
W
A
270
                   
P
L
F
I
L
L
L
L
D
V
280
    ECL3   TM7
G
C
K
V
K
T
C
D
I
L
290
                   
F
R
A
E
Y
F
L
V
L
A
300
                   
V
L
N
S
G
T
N
P
I
I
310
        H8        
Y
T
L
T
N
K
E
M
R
R
320
                   
A
F
I
R
I
M
S
C
C
K
330
C-term        
C
P
S
G
D
S
A
G
K
F
340
                   
K
R
P
I
I
A
G
M
E
F
350
                   
S
R
S
K
S
D
N
S
S
H
360
                   
P
Q
K
D
E
G
D
N
P
E
370
                   
T
I
M
S
S
G
N
V
N
S
380
   
S
S

LINKS

DIAGRAMS

ICL1 K K F H ICL1ECL1 G A T T Y K L ECL1ICL2 M K L H N G S ICL2ECL2 W N C I S A L S S C S T V L P L Y ECL2ICL3 F R K N I S K A ICL3ECL3 K V K T C ECL3N-term M G P T S V P L V K A H R S S V S D Y V N Y D I I V R H Y N Y T G K L N I S A D K N-termC-term C C K C P S G D S A G K F K R P I I A G M E F S R S K S D N S S H P Q K D E G D N P E T I M S S G N V N S S S C-term E N S I K L T S V V F I L I C C F I I L E N I F V L L T I W K T R P M Y Y F I G N L A L S D L L A G V A Y T A N L L L S T P A Q W F L R E G S M F V A L S A S V F S L L A I A I E R Y I T M L K N N F R L F L L I S A C W V I S L I L G G L P I M G H K H Y I L F C T T V F T L L L L S I V I L Y C R I Y S L V R T R S R R L T S R S S E K S L A L L K T V I I V L S V F I A C W A P L F I L L L L D V G C D I L F R A E Y F L V L A V L N S G T N P I I Y T L T N K E F I R M R R A I M S
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

I N E L I I F C C I L I F V V S T L K I 1 G N L A L S D L L A G V A Y T A N L L L 2 A L L S F V S A S L A V F M S G E R L F 3 L F L L I S A C W V I S L I L G G L P I 4 Y L I V I S L L L L T F V T T C F L I Y 5 I I V L S V F I A C W A P L F I L L L L 6 I P N T G S N L V A L V L F Y E A R F 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

PHYSIOLOGICAL LIGANDS

sphingosine 1-phosphate, dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine

STRUCTURE MODELS

STRUCTURES

Found 16 structure(s) - view all details on the Structures page

PDBs: 3V2W, 3V2Y, 7EO2, 7EO4, 7WF7, 7EVY, 7EVZ, 7EW0, 7EW7, 7TD3, 7TD4, 7VIE, 7VIF, 7VIG, 7VIH, 8G94