S1P1 receptor (s1pr1_human)
FAMILY
Class A (Rhodopsin) Lipid receptors Lysophospholipid (S1P) receptors S1P1 receptor
GENE
S1PR1 (CHEDG1, EDG1)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Sphingosine 1-phosphate receptor 1, S1P receptor 1, S1P1, Endothelial differentiation G-protein coupled receptor 1, Sphingosine 1-phosphate receptor Edg-1, S1P receptor Edg-1, CD363
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
G
|
P
|
T
|
S
|
V
|
P
|
L
|
V
|
K
|
10 |
A
|
H
|
R
|
S
|
S
|
V
|
S
|
D
|
Y
|
V
|
20 |
N
|
Y
|
D
|
I
|
I
|
V
|
R
|
H
|
Y
|
N
|
30 |
Y
|
T
|
G
|
K
|
L
|
N
|
I
|
S
|
A
|
D
|
40 |
TM1 | |||||||||
K
|
E
|
N
|
S
|
I
|
K
|
L
|
T
|
S
|
V
|
50 |
V
|
F
|
I
|
L
|
I
|
C
|
C
|
F
|
I
|
I
|
60 |
L
|
E
|
N
|
I
|
F
|
V
|
L
|
L
|
T
|
I
|
70 |
ICL1 | TM2 | ||||||||
W
|
K
|
T
|
K
|
K
|
F
|
H
|
R
|
P
|
M
|
80 |
Y
|
Y
|
F
|
I
|
G
|
N
|
L
|
A
|
L
|
S
|
90 |
D
|
L
|
L
|
A
|
G
|
V
|
A
|
Y
|
T
|
A
|
100 |
ECL1 | |||||||||
N
|
L
|
L
|
L
|
S
|
G
|
A
|
T
|
T
|
Y
|
110 |
TM3 | |||||||||
K
|
L
|
T
|
P
|
A
|
Q
|
W
|
F
|
L
|
R
|
120 |
E
|
G
|
S
|
M
|
F
|
V
|
A
|
L
|
S
|
A
|
130 |
S
|
V
|
F
|
S
|
L
|
L
|
A
|
I
|
A
|
I
|
140 |
E
|
R
|
Y
|
I
|
T
|
M
|
L
|
K
|
M
|
K
|
150 |
ICL2 | TM4 | ||||||||
L
|
H
|
N
|
G
|
S
|
N
|
N
|
F
|
R
|
L
|
160 |
F
|
L
|
L
|
I
|
S
|
A
|
C
|
W
|
V
|
I
|
170 |
S
|
L
|
I
|
L
|
G
|
G
|
L
|
P
|
I
|
M
|
180 |
ECL2 | |||||||||
G
|
W
|
N
|
C
|
I
|
S
|
A
|
L
|
S
|
S
|
190 |
C
|
S
|
T
|
V
|
L
|
P
|
L
|
Y
|
H
|
K
|
200 |
TM5 | |||||||||
H
|
Y
|
I
|
L
|
F
|
C
|
T
|
T
|
V
|
F
|
210 |
T
|
L
|
L
|
L
|
L
|
S
|
I
|
V
|
I
|
L
|
220 |
Y
|
C
|
R
|
I
|
Y
|
S
|
L
|
V
|
R
|
T
|
230 |
ICL3 | |||||||||
R
|
S
|
R
|
R
|
L
|
T
|
F
|
R
|
K
|
N
|
240 |
TM6 | |||||||||
I
|
S
|
K
|
A
|
S
|
R
|
S
|
S
|
E
|
K
|
250 |
S
|
L
|
A
|
L
|
L
|
K
|
T
|
V
|
I
|
I
|
260 |
V
|
L
|
S
|
V
|
F
|
I
|
A
|
C
|
W
|
A
|
270 |
P
|
L
|
F
|
I
|
L
|
L
|
L
|
L
|
D
|
V
|
280 |
ECL3 | TM7 | ||||||||
G
|
C
|
K
|
V
|
K
|
T
|
C
|
D
|
I
|
L
|
290 |
F
|
R
|
A
|
E
|
Y
|
F
|
L
|
V
|
L
|
A
|
300 |
V
|
L
|
N
|
S
|
G
|
T
|
N
|
P
|
I
|
I
|
310 |
H8 | |||||||||
Y
|
T
|
L
|
T
|
N
|
K
|
E
|
M
|
R
|
R
|
320 |
A
|
F
|
I
|
R
|
I
|
M
|
S
|
C
|
C
|
K
|
330 |
C-term | |||||||||
C
|
P
|
S
|
G
|
D
|
S
|
A
|
G
|
K
|
F
|
340 |
K
|
R
|
P
|
I
|
I
|
A
|
G
|
M
|
E
|
F
|
350 |
S
|
R
|
S
|
K
|
S
|
D
|
N
|
S
|
S
|
H
|
360 |
P
|
Q
|
K
|
D
|
E
|
G
|
D
|
N
|
P
|
E
|
370 |
T
|
I
|
M
|
S
|
S
|
G
|
N
|
V
|
N
|
S
|
380 |
S
|
S
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
sphingosine 1-phosphate, dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine