S1P1 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.9 Å

REFERENCE

PUBLICATION DATE

Jan. 5, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

(S)-FTY720-phosphate - Agonist pubchem gtoplig chembl_ligand

ENDOGENOUS LIGANDS

sphingosylphosphorylcholine, dihydrosphingosine 1-phosphate, sphingosine 1-phosphate



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Polar TM3 R 142 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 142 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL3 L 235 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 L 235 - G.H5 D 337 G.H5.09
Hydrophobic TM3 T 145 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 M 146 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 M 146 3x54 G.H5 L 348 G.H5.20
Van-der-waals ICL3 F 237 - G.H5 D 341 G.H5.13
Hydrophobic TM5 R 231 5x68 G.H5 I 344 G.H5.16
Hydrophobic ICL3 F 237 - G.H5 F 334 G.H5.06
Van-der-waals ICL3 F 237 - G.H5 F 334 G.H5.06
Hydrophobic TM3 M 146 3x54 G.H5 N 347 G.H5.19
Polar ICL3 T 236 - G.H5 D 337 G.H5.09
Hydrophobic TM3 M 146 3x54 G.H5 C 351 G.H5.23
Ionic TM2 R 78 2x37 G.H5 D 350 G.H5.22
Polar TM2 R 78 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 R 78 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 R 78 2x37 G.H5 D 350 G.H5.22
Hydrophobic ICL3 L 235 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 L 235 - G.H5 D 341 G.H5.13
Hydrophobic TM6 L 254 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM5 S 232 5x69 G.H5 I 344 G.H5.16
Van-der-waals TM5 S 232 5x69 G.H5 I 344 G.H5.16
Polar ICL2 L 151 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 L 151 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 L 151 - G.H5 N 347 G.H5.19
Hydrophobic ICL3 L 235 - G.H5 T 340 G.H5.12
Hydrophobic TM5 V 228 5x65 G.H5 L 348 G.H5.20
Aromatic ICL3 F 237 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 F 237 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 F 237 - G.S6 Y 320 G.S6.02
Hydrophobic TM2 M 80 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM5 I 224 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 I 224 5x61 G.H5 L 353 G.H5.25