S1P1 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

F

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.0 Å

REFERENCE

PUBLICATION DATE

Sept. 28, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

icanbelimod - Agonist pubchem gtoplig chembl_ligand

ENDOGENOUS LIGANDS

sphingosine 1-phosphate, sphingosylphosphorylcholine, dihydrosphingosine 1-phosphate



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

GPCR AA GPCR number GPCRdb# Segment G protein AA G protein number CGN# Interaction Type
M 80 2x39 TM2 C 351 G.H5.23 hydrophobic
M 80 2x39 TM2 C 351 G.H5.23 van-der-waals
T 257 6x36 TM6 L 353 G.H5.25 hydrophobic
L 151 - ICL2 E 33 G.S1.01 hydrophobic
L 151 - ICL2 E 33 G.S1.01 van-der-waals
F 237 - ICL3 D 337 G.H5.09 hydrophobic
L 151 - ICL2 V 34 G.S1.02 hydrophobic
L 151 - ICL2 V 34 G.S1.02 van-der-waals
M 149 - ICL2 I 343 G.H5.15 hydrophobic
N 153 - ICL2 D 350 G.H5.22 polar
N 153 - ICL2 D 350 G.H5.22 hydrophobic
N 153 - ICL2 D 350 G.H5.22 van-der-waals
L 151 - ICL2 T 219 G.h2s4.05 van-der-waals
R 231 5x68 TM5 I 344 G.H5.16 hydrophobic
L 235 5x72 TM5 D 337 G.H5.09 hydrophobic
L 235 5x72 TM5 D 337 G.H5.09 van-der-waals
K 316 8x48 H8 F 354 G.H5.26 polar
K 316 8x48 H8 F 354 G.H5.26 aromatic
K 316 8x48 H8 F 354 G.H5.26 hydrophobic
K 250 6x29 TM6 L 348 G.H5.20 hydrophobic
M 146 3x54 TM3 N 347 G.H5.19 hydrophobic
M 146 3x54 TM3 N 347 G.H5.19 van-der-waals
N 315 8x47 H8 G 352 G.H5.24 polar
N 315 8x47 H8 G 352 G.H5.24 hydrophobic
N 315 8x47 H8 G 352 G.H5.24 van-der-waals
R 142 3x50 TM3 C 351 G.H5.23 polar
R 142 3x50 TM3 C 351 G.H5.23 hydrophobic
K 148 3x56 TM3 N 347 G.H5.19 polar
I 224 5x61 TM5 L 353 G.H5.25 hydrophobic
T 145 3x53 TM3 C 351 G.H5.23 hydrophobic
T 145 3x53 TM3 C 351 G.H5.23 van-der-waals
L 235 5x72 TM5 T 340 G.H5.12 hydrophobic
M 146 3x54 TM3 L 348 G.H5.20 hydrophobic
L 254 6x33 TM6 L 353 G.H5.25 hydrophobic
L 254 6x33 TM6 L 353 G.H5.25 van-der-waals
K 250 6x29 TM6 I 344 G.H5.16 hydrophobic
R 78 2x37 TM2 K 349 G.H5.21 polar
R 78 2x37 TM2 K 349 G.H5.21 van-der-waals
L 151 - ICL2 R 32 G.hns1.03 hydrophobic
M 80 2x39 TM2 D 350 G.H5.22 hydrophobic
M 80 2x39 TM2 D 350 G.H5.22 van-der-waals
F 237 - ICL3 A 338 G.H5.10 hydrophobic
F 237 - ICL3 F 334 G.H5.06 hydrophobic
T 236 - ICL3 D 337 G.H5.09 polar
T 236 - ICL3 D 337 G.H5.09 van-der-waals
F 237 - ICL3 D 341 G.H5.13 hydrophobic
F 237 - ICL3 D 341 G.H5.13 van-der-waals
M 149 - ICL2 N 347 G.H5.19 polar
M 149 - ICL2 N 347 G.H5.19 hydrophobic
M 149 - ICL2 N 347 G.H5.19 van-der-waals
N 315 8x47 H8 F 354 G.H5.26 polar
N 315 8x47 H8 F 354 G.H5.26 van-der-waals
L 151 - ICL2 I 343 G.H5.15 hydrophobic
R 142 3x50 TM3 L 353 G.H5.25 hydrophobic
L 235 5x72 TM5 D 341 G.H5.13 hydrophobic
L 254 6x33 TM6 L 348 G.H5.20 hydrophobic
F 237 - ICL3 Y 320 G.S6.02 aromatic
F 237 - ICL3 Y 320 G.S6.02 hydrophobic
K 250 6x29 TM6 D 341 G.H5.13 ionic
K 250 6x29 TM6 D 341 G.H5.13 polar
K 250 6x29 TM6 D 341 G.H5.13 hydrophobic
K 250 6x29 TM6 D 341 G.H5.13 van-der-waals
R 78 2x37 TM2 D 350 G.H5.22 ionic
R 78 2x37 TM2 D 350 G.H5.22 polar
R 78 2x37 TM2 D 350 G.H5.22 hydrophobic
R 78 2x37 TM2 D 350 G.H5.22 van-der-waals
K 150 - ICL2 I 343 G.H5.15 hydrophobic
K 150 - ICL2 I 343 G.H5.15 van-der-waals
T 145 3x53 TM3 N 347 G.H5.19 polar
T 145 3x53 TM3 N 347 G.H5.19 hydrophobic
M 146 3x54 TM3 C 351 G.H5.23 hydrophobic
M 146 3x54 TM3 C 351 G.H5.23 van-der-waals