ACKR1 (ackr1_human)

FAMILY

Class A (Rhodopsin) Protein receptors Chemokine receptors ACKR1

GENE

ACKR1 (DARC, FY, GPD)

ORGANISM

Human (Homo sapiens)

ALT. NAMES

Atypical chemokine receptor 1, Duffy antigen/chemokine receptor, Fy glycoprotein, GpFy, Glycoprotein D, Plasmodium vivax receptor, CD234

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
G
N
C
L
H
R
A
E
L
10
                   
S
P
S
T
E
N
S
S
Q
L
20
                   
D
F
E
D
V
W
N
S
S
Y
30
                   
G
V
N
D
S
F
P
D
G
D
40
                   
Y
G
A
N
L
E
A
A
A
P
50
              TM1
C
H
S
C
N
L
L
D
D
S
60
                   
A
L
P
F
F
I
L
T
S
V
70
                   
L
G
I
L
A
S
S
T
V
L
80
            ICL1
F
M
L
F
R
P
L
F
R
W
90
        TM2      
Q
L
C
P
G
W
P
V
L
A
100
                   
Q
L
A
V
G
S
A
L
F
S
110
                   
I
V
V
P
V
L
A
P
G
L
120
ECL1 TM3      
G
S
T
R
S
S
A
L
C
S
130
                   
L
G
Y
C
V
W
Y
G
S
A
140
                   
F
A
Q
A
L
L
L
G
C
H
150
                   
A
S
L
G
H
R
L
G
A
G
160
ICL2 TM4      
Q
V
P
G
L
T
L
G
L
T
170
                   
V
G
I
W
G
V
A
A
L
L
180
                   
T
L
P
V
T
L
A
S
G
A
190
ECL2            
S
G
G
L
C
T
L
I
Y
S
200
    TM5          
T
E
L
K
A
L
Q
A
T
H
210
                   
T
V
A
C
L
A
I
F
V
L
220
                   
L
P
L
G
L
F
G
A
K
G
230
    ICL3        
L
K
K
A
L
G
M
G
P
G
240
TM6              
P
W
M
N
I
L
W
A
W
F
250
                   
I
F
W
W
P
H
G
V
V
L
260
                   
G
L
D
F
L
V
R
S
K
L
270
ECL3 TM7      
L
L
L
S
T
C
L
A
Q
Q
280
                   
A
L
D
L
L
L
N
L
A
E
290
                   
A
L
A
I
L
H
C
V
A
T
300
              H8  
P
L
L
L
A
L
F
C
H
Q
310
                   
A
T
R
T
L
L
P
S
L
P
320
    C-term    
L
P
E
G
W
S
S
H
L
D
330
           
T
L
G
S
K
S

LINKS

Guide To Pharmacology

UniProt

DIAGRAMS

7TM

ICL1 L F R W Q L C P ICL1ECL1 P G L G S T R ECL1ICL2 G Q ICL2ECL2 G A S G G L C T L I Y S T E ECL2ICL3 K A L G M G ICL3ECL3 L L L L S ECL3N-term M G N C L H R A E L S P S T E N S S Q L D F E D V W N S S Y G V N D S F P D G D Y G A N L E A A A P C H S C N L L N-termC-term E G W S S H L D T L G S K S C-term D D S A L P F F I L T S V L G I L A S S T V L F M L F R P G W P V L A Q L A V G S A L F S I V V P V L A S S A L C S L G Y C V W Y G S A F A Q A L L L G C H A S L G H R L G A V P G L T L G L T V G I W G V A A L L T L P V T L A S L K A L Q A T H T V A C L A I F V L L P L G L F G A K G L K P G P W M N I L W A W F I F W W P H G V V L G L D F L V R S K T C L A Q Q A L D L L L N L A E A L A I L H C V A T P L L L A L F C H Q L L P P A T R T S L P L
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

S S A L I G L V S T L I F F P L A S D D 1 A Q L A V G S A L F S I V V P V L A 2 C G L L L A Q A F A S G Y W V C Y G L S 3 T L G L T V G I W G V A A L L T L P V 4 F L G L P L L V F I A L C A V T H T A Q 5 M N I L W A W F I F W W P H G V V L G L 6 L P T A V C H L I A L A E A L N L L L 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

10 mutation data points available.

PHYSIOLOGICAL LIGANDS

CCL11, CCL14, CCL2, CXCL8, CXCL11, CCL5, CXCL6, CCL7, CXCL5, CCL17

STRUCTURE MODELS

ackr1_human inactive,

ackr1_human active

STRUCTURES

Found 1 structure(s) - view all details on the Structures page

PDBs: 8JPS