ACKR1 (ackr1_human)
FAMILY
Class A (Rhodopsin) Protein receptors Chemokine receptors ACKR1
GENE
ACKR1 (DARC, FY, GPD)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Atypical chemokine receptor 1, Duffy antigen/chemokine receptor, Fy glycoprotein, GpFy, Glycoprotein D, Plasmodium vivax receptor, CD234
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
G
|
N
|
C
|
L
|
H
|
R
|
A
|
E
|
L
|
10 |
S
|
P
|
S
|
T
|
E
|
N
|
S
|
S
|
Q
|
L
|
20 |
D
|
F
|
E
|
D
|
V
|
W
|
N
|
S
|
S
|
Y
|
30 |
G
|
V
|
N
|
D
|
S
|
F
|
P
|
D
|
G
|
D
|
40 |
Y
|
G
|
A
|
N
|
L
|
E
|
A
|
A
|
A
|
P
|
50 |
TM1 | |||||||||
C
|
H
|
S
|
C
|
N
|
L
|
L
|
D
|
D
|
S
|
60 |
A
|
L
|
P
|
F
|
F
|
I
|
L
|
T
|
S
|
V
|
70 |
L
|
G
|
I
|
L
|
A
|
S
|
S
|
T
|
V
|
L
|
80 |
ICL1 | |||||||||
F
|
M
|
L
|
F
|
R
|
P
|
L
|
F
|
R
|
W
|
90 |
TM2 | |||||||||
Q
|
L
|
C
|
P
|
G
|
W
|
P
|
V
|
L
|
A
|
100 |
Q
|
L
|
A
|
V
|
G
|
S
|
A
|
L
|
F
|
S
|
110 |
I
|
V
|
V
|
P
|
V
|
L
|
A
|
P
|
G
|
L
|
120 |
ECL1 | TM3 | ||||||||
G
|
S
|
T
|
R
|
S
|
S
|
A
|
L
|
C
|
S
|
130 |
L
|
G
|
Y
|
C
|
V
|
W
|
Y
|
G
|
S
|
A
|
140 |
F
|
A
|
Q
|
A
|
L
|
L
|
L
|
G
|
C
|
H
|
150 |
A
|
S
|
L
|
G
|
H
|
R
|
L
|
G
|
A
|
G
|
160 |
ICL2 | TM4 | ||||||||
Q
|
V
|
P
|
G
|
L
|
T
|
L
|
G
|
L
|
T
|
170 |
V
|
G
|
I
|
W
|
G
|
V
|
A
|
A
|
L
|
L
|
180 |
T
|
L
|
P
|
V
|
T
|
L
|
A
|
S
|
G
|
A
|
190 |
ECL2 | |||||||||
S
|
G
|
G
|
L
|
C
|
T
|
L
|
I
|
Y
|
S
|
200 |
TM5 | |||||||||
T
|
E
|
L
|
K
|
A
|
L
|
Q
|
A
|
T
|
H
|
210 |
T
|
V
|
A
|
C
|
L
|
A
|
I
|
F
|
V
|
L
|
220 |
L
|
P
|
L
|
G
|
L
|
F
|
G
|
A
|
K
|
G
|
230 |
ICL3 | |||||||||
L
|
K
|
K
|
A
|
L
|
G
|
M
|
G
|
P
|
G
|
240 |
TM6 | |||||||||
P
|
W
|
M
|
N
|
I
|
L
|
W
|
A
|
W
|
F
|
250 |
I
|
F
|
W
|
W
|
P
|
H
|
G
|
V
|
V
|
L
|
260 |
G
|
L
|
D
|
F
|
L
|
V
|
R
|
S
|
K
|
L
|
270 |
ECL3 | TM7 | ||||||||
L
|
L
|
L
|
S
|
T
|
C
|
L
|
A
|
Q
|
Q
|
280 |
A
|
L
|
D
|
L
|
L
|
L
|
N
|
L
|
A
|
E
|
290 |
A
|
L
|
A
|
I
|
L
|
H
|
C
|
V
|
A
|
T
|
300 |
H8 | |||||||||
P
|
L
|
L
|
L
|
A
|
L
|
F
|
C
|
H
|
Q
|
310 |
A
|
T
|
R
|
T
|
L
|
L
|
P
|
S
|
L
|
P
|
320 |
C-term | |||||||||
L
|
P
|
E
|
G
|
W
|
S
|
S
|
H
|
L
|
D
|
330 |
T
|
L
|
G
|
S
|
K
|
S
|
LINKS
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
CCL11, CCL14, CCL2, CXCL8, CXCL11, CCL5, CXCL6, CCL7, CXCL5, CCL17
STRUCTURE MODELS
STRUCTURES
No structures available