LPA3 receptor (lpar3_mouse)

FAMILY

Class A (Rhodopsin) Lipid receptors Lysophospholipid (LPA) receptors LPA3 receptor

GENE

Lpar3 (Edg7, Lpa3)

ORGANISM

Mouse (Mus musculus)

ALT. NAMES

Lysophosphatidic acid receptor 3, LPA receptor 3, LPA-3, Lysophosphatidic acid receptor Edg-7

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
N
E
C
H
Y
D
K
R
M
10
                   
D
F
F
Y
N
R
S
N
T
D
20
              TM1
T
A
D
E
W
T
G
T
K
L
30
                   
V
I
V
L
C
V
G
T
F
F
40
                   
C
L
F
I
F
F
S
N
S
L
50
                   
V
I
A
A
V
I
T
N
R
K
60
ICL1 TM2      
F
H
F
P
F
Y
Y
L
L
A
70
                   
N
L
A
A
A
D
F
F
A
G
80
                   
I
A
Y
V
F
L
M
F
N
T
90
ECL1       TM3
G
P
V
S
K
T
L
T
V
N
100
                   
R
W
F
L
R
Q
G
L
L
D
110
                   
T
S
L
T
A
S
L
A
N
L
120
                   
L
V
I
A
V
E
R
H
M
S
130
      ICL2      
I
M
R
M
R
V
H
S
N
L
140
TM4              
T
K
K
R
V
T
L
L
I
L
150
                   
L
V
W
A
I
A
I
F
M
G
160
            ECL2
A
V
P
T
L
G
W
N
C
L
170
                   
C
N
I
S
A
C
S
S
L
A
180
      TM5        
P
I
Y
S
R
S
Y
L
I
F
190
                   
W
T
V
S
N
L
L
A
F
F
200
                   
I
M
V
A
V
Y
V
R
I
Y
210
                   
M
Y
V
K
R
K
T
N
V
L
220
  ICL3 TM6    
S
P
H
T
S
G
S
I
S
R
230
                   
R
R
A
P
M
K
L
M
K
T
240
                   
V
M
T
V
L
G
A
F
V
V
250
                   
C
W
T
P
G
L
V
V
L
L
260
          ECL3  
L
D
G
L
N
C
K
Q
C
N
270
TM7              
V
Q
H
V
K
R
W
F
L
L
280
                   
L
A
L
L
N
S
V
M
N
P
290
            H8    
I
I
Y
S
Y
K
D
E
D
M
300
                   
Y
N
T
M
R
K
M
I
C
C
310
C-term        
A
L
Q
D
S
N
T
E
R
R
320
                   
P
S
R
N
P
S
T
I
H
S
330
                   
R
S
E
T
G
S
Q
Y
L
E
340
                   
D
S
I
S
Q
G
P
V
C
N
350
       
K
N
G
S

LINKS

DIAGRAMS

ICL1 R K F H ICL1ECL1 T G P V S K T L ECL1ICL2 M R V H S N L ICL2ECL2 W N C L C N I S A C S S L A P I Y ECL2ICL3 P H T S ICL3ECL3 C K Q C ECL3N-term M N E C H Y D K R M D F F Y N R S N T D T A D E W T G N-termC-term C A L Q D S N T E R R P S R N P S T I H S R S E T G S Q Y L E D S I S Q G P V C N K N G S C-term T K L V I V L C V G T F F C L F I F F S N S L V I A A V I T N F P F Y Y L L A N L A A A D F F A G I A Y V F L M F N T V N R W F L R Q G L L D T S L T A S L A N L L V I A V E R H M S I M R T K K R V T L L I L L V W A I A I F M G A V P T L G S R S Y L I F W T V S N L L A F F I M V A V Y V R I Y M Y V K R K T N V L S G S I S R R R A P M K L M K T V M T V L G A F V V C W T P G L V V L L L D G L N N V Q H V K R W F L L L A L L N S V M N P I I Y S Y K D E D M R K M Y N T M I C
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

S N S F F I F L C F F T G V C L V I V L 1 A N L A A A D F F A G I A Y V F L M F N 2 V L L N A L S A T L S T D L L G Q R L F 3 V T L L I L L V W A I A I F M G A V P T 4 Y V A V M I F F A L L N S V T W F I L Y 5 M T V L G A F V V C W T P G L V V L L L 6 I P N M V S N L L A L L L F W R K V H 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

PHYSIOLOGICAL LIGANDS

LPA, 1-O-Oleoyl-D-glycerol 3-phosphoric acid, LYSOPHOSPHATIDIC ACID

STRUCTURE MODELS

No structure models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available