P2Y2 receptor (p2ry2_human)
FAMILY
Class A (Rhodopsin) Nucleotide receptors P2Y receptors P2Y2 receptor
GENE
P2RY2 (P2RU1)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
P2Y purinoceptor 2, P2Y2, ATP receptor, P2U purinoceptor 1, P2U1, P2U receptor 1, Purinergic receptor
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
A
|
A
|
D
|
L
|
G
|
P
|
W
|
N
|
D
|
10 |
T
|
I
|
N
|
G
|
T
|
W
|
D
|
G
|
D
|
E
|
20 |
L
|
G
|
Y
|
R
|
C
|
R
|
F
|
N
|
E
|
D
|
30 |
TM1 | |||||||||
F
|
K
|
Y
|
V
|
L
|
L
|
P
|
V
|
S
|
Y
|
40 |
G
|
V
|
V
|
C
|
V
|
P
|
G
|
L
|
C
|
L
|
50 |
N
|
A
|
V
|
A
|
L
|
Y
|
I
|
F
|
L
|
C
|
60 |
ICL1 | TM2 | ||||||||
R
|
L
|
K
|
T
|
W
|
N
|
A
|
S
|
T
|
T
|
70 |
Y
|
M
|
F
|
H
|
L
|
A
|
V
|
S
|
D
|
A
|
80 |
L
|
Y
|
A
|
A
|
S
|
L
|
P
|
L
|
L
|
V
|
90 |
ECL1 | |||||||||
Y
|
Y
|
Y
|
A
|
R
|
G
|
D
|
H
|
W
|
P
|
100 |
TM3 | |||||||||
F
|
S
|
T
|
V
|
L
|
C
|
K
|
L
|
V
|
R
|
110 |
F
|
L
|
F
|
Y
|
T
|
N
|
L
|
Y
|
C
|
S
|
120 |
I
|
L
|
F
|
L
|
T
|
C
|
I
|
S
|
V
|
H
|
130 |
R
|
C
|
L
|
G
|
V
|
L
|
R
|
P
|
L
|
R
|
140 |
ICL2 | TM4 | ||||||||
S
|
L
|
R
|
W
|
G
|
R
|
A
|
R
|
Y
|
A
|
150 |
R
|
R
|
V
|
A
|
G
|
A
|
V
|
W
|
V
|
L
|
160 |
V
|
L
|
A
|
C
|
Q
|
A
|
P
|
V
|
L
|
Y
|
170 |
ECL2 | |||||||||
F
|
V
|
T
|
T
|
S
|
A
|
R
|
G
|
G
|
R
|
180 |
V
|
T
|
C
|
H
|
D
|
T
|
S
|
A
|
P
|
E
|
190 |
TM5 | |||||||||
L
|
F
|
S
|
R
|
F
|
V
|
A
|
Y
|
S
|
S
|
200 |
V
|
M
|
L
|
G
|
L
|
L
|
F
|
A
|
V
|
P
|
210 |
F
|
A
|
V
|
I
|
L
|
V
|
C
|
Y
|
V
|
L
|
220 |
M
|
A
|
R
|
R
|
L
|
L
|
K
|
P
|
A
|
Y
|
230 |
ICL3 | TM6 | ||||||||
G
|
T
|
S
|
G
|
G
|
L
|
P
|
R
|
A
|
K
|
240 |
R
|
K
|
S
|
V
|
R
|
T
|
I
|
A
|
V
|
V
|
250 |
L
|
A
|
V
|
F
|
A
|
L
|
C
|
F
|
L
|
P
|
260 |
F
|
H
|
V
|
T
|
R
|
T
|
L
|
Y
|
Y
|
S
|
270 |
ECL3 | TM7 | ||||||||
F
|
R
|
S
|
L
|
D
|
L
|
S
|
C
|
H
|
T
|
280 |
L
|
N
|
A
|
I
|
N
|
M
|
A
|
Y
|
K
|
V
|
290 |
T
|
R
|
P
|
L
|
A
|
S
|
A
|
N
|
S
|
C
|
300 |
L
|
D
|
P
|
V
|
L
|
Y
|
F
|
L
|
A
|
G
|
310 |
H8 | |||||||||
Q
|
R
|
L
|
V
|
R
|
F
|
A
|
R
|
D
|
A
|
320 |
C-term | |||||||||
K
|
P
|
P
|
T
|
G
|
P
|
S
|
P
|
A
|
T
|
330 |
P
|
A
|
R
|
R
|
R
|
L
|
G
|
L
|
R
|
R
|
340 |
S
|
D
|
R
|
T
|
D
|
M
|
Q
|
R
|
I
|
E
|
350 |
D
|
V
|
L
|
G
|
S
|
S
|
E
|
D
|
S
|
R
|
360 |
R
|
T
|
E
|
S
|
T
|
P
|
A
|
G
|
S
|
E
|
370 |
N
|
T
|
K
|
D
|
I
|
R
|
L
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
UTP, ATP
STRUCTURE MODELS
STRUCTURES
No structures available