H4 receptor (hrh4_rat)
FAMILY
Class A (Rhodopsin) Aminergic receptors Histamine receptors H4 receptor
GENE
Hrh4
ORGANISM
Rat (Rattus norvegicus)
ALT. NAMES
Histamine H4 receptor, H4R, HH4R
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
S
|
E
|
S
|
N
|
G
|
T
|
D
|
V
|
L
|
10 |
TM1 | |||||||||
P
|
L
|
T
|
A
|
Q
|
V
|
P
|
L
|
A
|
F
|
20 |
L
|
M
|
S
|
L
|
L
|
A
|
F
|
A
|
I
|
T
|
30 |
I
|
G
|
N
|
A
|
V
|
V
|
I
|
L
|
A
|
F
|
40 |
ICL1 | TM2 | ||||||||
V
|
A
|
D
|
R
|
N
|
L
|
R
|
H
|
R
|
S
|
50 |
N
|
Y
|
F
|
F
|
L
|
N
|
L
|
A
|
I
|
S
|
60 |
D
|
F
|
F
|
V
|
G
|
V
|
I
|
S
|
I
|
P
|
70 |
L
|
Y
|
I
|
P
|
H
|
T
|
L
|
F
|
N
|
W
|
80 |
ECL1 | TM3 | ||||||||
N
|
F
|
G
|
S
|
G
|
I
|
C
|
M
|
F
|
W
|
90 |
L
|
I
|
T
|
D
|
Y
|
L
|
L
|
C
|
T
|
A
|
100 |
S
|
V
|
Y
|
S
|
I
|
V
|
L
|
I
|
S
|
Y
|
110 |
D
|
R
|
Y
|
Q
|
S
|
V
|
S
|
N
|
A
|
V
|
120 |
ICL2 | TM4 | ||||||||
R
|
Y
|
R
|
A
|
Q
|
H
|
T
|
G
|
I
|
L
|
130 |
K
|
I
|
V
|
A
|
Q
|
M
|
V
|
A
|
V
|
W
|
140 |
I
|
L
|
A
|
F
|
L
|
V
|
N
|
G
|
P
|
M
|
150 |
I
|
L
|
A
|
S
|
D
|
S
|
W
|
K
|
N
|
S
|
160 |
ECL2 | |||||||||
T
|
N
|
T
|
E
|
E
|
C
|
E
|
P
|
G
|
F
|
170 |
TM5 | |||||||||
V
|
T
|
E
|
W
|
Y
|
I
|
L
|
A
|
I
|
T
|
180 |
A
|
F
|
L
|
E
|
F
|
L
|
L
|
P
|
V
|
S
|
190 |
L
|
V
|
V
|
Y
|
F
|
S
|
V
|
Q
|
I
|
Y
|
200 |
W
|
S
|
L
|
W
|
K
|
R
|
G
|
S
|
L
|
S
|
210 |
ICL3 | |||||||||
R
|
C
|
P
|
S
|
H
|
A
|
G
|
F
|
I
|
A
|
220 |
T
|
S
|
S
|
R
|
G
|
T
|
G
|
H
|
S
|
R
|
230 |
R
|
T
|
G
|
L
|
A
|
C
|
R
|
T
|
S
|
L
|
240 |
P
|
G
|
L
|
K
|
E
|
P
|
A
|
A
|
S
|
L
|
250 |
H
|
S
|
E
|
S
|
P
|
R
|
G
|
K
|
S
|
S
|
260 |
L
|
L
|
V
|
S
|
L
|
R
|
T
|
H
|
M
|
S
|
270 |
G
|
S
|
I
|
I
|
A
|
F
|
K
|
V
|
G
|
S
|
280 |
F
|
C
|
R
|
S
|
E
|
S
|
P
|
V
|
L
|
H
|
290 |
TM6 | |||||||||
Q
|
R
|
E
|
H
|
V
|
E
|
L
|
L
|
R
|
G
|
300 |
R
|
K
|
L
|
A
|
R
|
S
|
L
|
A
|
V
|
L
|
310 |
L
|
S
|
A
|
F
|
A
|
I
|
C
|
W
|
A
|
P
|
320 |
Y
|
C
|
L
|
F
|
T
|
I
|
V
|
L
|
S
|
T
|
330 |
ECL3 | |||||||||
Y
|
R
|
R
|
G
|
E
|
R
|
P
|
K
|
S
|
I
|
340 |
TM7 | |||||||||
W
|
Y
|
S
|
I
|
A
|
F
|
W
|
L
|
Q
|
W
|
350 |
F
|
N
|
S
|
L
|
I
|
N
|
P
|
F
|
L
|
Y
|
360 |
H8 | |||||||||
P
|
L
|
C
|
H
|
R
|
R
|
F
|
Q
|
K
|
A
|
370 |
F
|
W
|
K
|
I
|
L
|
C
|
V
|
T
|
K
|
Q
|
380 |
C-term | |||||||||
P
|
A
|
P
|
S
|
Q
|
T
|
Q
|
S
|
V
|
S
|
390 |
S
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
histamine
STRUCTURE MODELS
No structure models available. Check the Archive on Structure models for earlier releases.
STRUCTURES
No structures available