PAF receptor (ptafr_human)
FAMILY
Class A (Rhodopsin) Lipid receptors Platelet-activating factor receptors PAF receptor
GENE
PTAFR (PAFR)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Platelet-activating factor receptor, PAF-R, PAFr
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
E
|
P
|
H
|
D
|
S
|
S
|
H
|
M
|
D
|
10 |
TM1 | |||||||||
S
|
E
|
F
|
R
|
Y
|
T
|
L
|
F
|
P
|
I
|
20 |
V
|
Y
|
S
|
I
|
I
|
F
|
V
|
L
|
G
|
V
|
30 |
I
|
A
|
N
|
G
|
Y
|
V
|
L
|
W
|
V
|
F
|
40 |
ICL1 | |||||||||
A
|
R
|
L
|
Y
|
P
|
C
|
K
|
K
|
F
|
N
|
50 |
TM2 | |||||||||
E
|
I
|
K
|
I
|
F
|
M
|
V
|
N
|
L
|
T
|
60 |
M
|
A
|
D
|
M
|
L
|
F
|
L
|
I
|
T
|
L
|
70 |
P
|
L
|
W
|
I
|
V
|
Y
|
Y
|
Q
|
N
|
Q
|
80 |
ECL1 | TM3 | ||||||||
G
|
N
|
W
|
I
|
L
|
P
|
K
|
F
|
L
|
C
|
90 |
N
|
V
|
A
|
G
|
C
|
L
|
F
|
F
|
I
|
N
|
100 |
T
|
Y
|
C
|
S
|
V
|
A
|
F
|
L
|
G
|
V
|
110 |
I
|
T
|
Y
|
N
|
R
|
F
|
Q
|
A
|
V
|
T
|
120 |
ICL2 | |||||||||
R
|
P
|
I
|
K
|
T
|
A
|
Q
|
A
|
N
|
T
|
130 |
TM4 | |||||||||
R
|
K
|
R
|
G
|
I
|
S
|
L
|
S
|
L
|
V
|
140 |
I
|
W
|
V
|
A
|
I
|
V
|
G
|
A
|
A
|
S
|
150 |
ECL2 | |||||||||
Y
|
F
|
L
|
I
|
L
|
D
|
S
|
T
|
N
|
T
|
160 |
V
|
P
|
D
|
S
|
A
|
G
|
S
|
G
|
N
|
V
|
170 |
T
|
R
|
C
|
F
|
E
|
H
|
Y
|
E
|
K
|
G
|
180 |
TM5 | |||||||||
S
|
V
|
P
|
V
|
L
|
I
|
I
|
H
|
I
|
F
|
190 |
I
|
V
|
F
|
S
|
F
|
F
|
L
|
V
|
F
|
L
|
200 |
I
|
I
|
L
|
F
|
C
|
N
|
L
|
V
|
I
|
I
|
210 |
ICL3 | |||||||||
R
|
T
|
L
|
L
|
M
|
Q
|
P
|
V
|
Q
|
Q
|
220 |
TM6 | |||||||||
Q
|
R
|
N
|
A
|
E
|
V
|
K
|
R
|
R
|
A
|
230 |
L
|
W
|
M
|
V
|
C
|
T
|
V
|
L
|
A
|
V
|
240 |
F
|
I
|
I
|
C
|
F
|
V
|
P
|
H
|
H
|
V
|
250 |
V
|
Q
|
L
|
P
|
W
|
T
|
L
|
A
|
E
|
L
|
260 |
ECL3 | TM7 | ||||||||
G
|
F
|
Q
|
D
|
S
|
K
|
F
|
H
|
Q
|
A
|
270 |
I
|
N
|
D
|
A
|
H
|
Q
|
V
|
T
|
L
|
C
|
280 |
L
|
L
|
S
|
T
|
N
|
C
|
V
|
L
|
D
|
P
|
290 |
V
|
I
|
Y
|
C
|
F
|
L
|
T
|
K
|
K
|
F
|
300 |
H8 | |||||||||
R
|
K
|
H
|
L
|
T
|
E
|
K
|
F
|
Y
|
S
|
310 |
C-term | |||||||||
M
|
R
|
S
|
S
|
R
|
K
|
C
|
S
|
R
|
A
|
320 |
T
|
T
|
D
|
T
|
V
|
T
|
E
|
V
|
V
|
V
|
330 |
P
|
F
|
N
|
Q
|
I
|
P
|
G
|
N
|
S
|
L
|
340 |
K
|
N
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
PAF
STRUCTURE MODELS
STRUCTURES
Found 2 structure(s) - view all details on the Structures page