PAF receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8XYD

RESOLUTION

2.9 Å

REFERENCE

10.1016/J.CELREP.2024.114422

PUBLICATION DATE

Nov. 13, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

PAF - Agonist pubchem gtoplig chembl_ligand drugbank gtoplig

PHYSIOLOGICAL LIGANDS

PAF



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 Q 127 34x55 G.S3 L 194 G.S3.01
Van-der-waals ICL2 Q 127 34x55 G.S3 L 194 G.S3.01
Polar TM7 K 298 7x58 G.H5 K 349 G.H5.21
Hydrophobic TM7 K 298 7x58 G.H5 K 349 G.H5.21
Van-der-waals TM7 K 298 7x58 G.H5 K 349 G.H5.21
Hydrophobic TM3 V 119 3x54 G.H5 L 348 G.H5.20
Polar ICL2 P 122 34x50 G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 122 34x50 G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 122 34x50 G.H5 N 347 G.H5.19
Hydrophobic TM2 I 52 2x39 G.H5 C 351 G.H5.23
Polar ICL2 Q 127 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 Q 127 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 Q 127 34x55 G.hns1 R 32 G.hns1.03
Polar ICL2 T 125 34x53 G.H5 N 347 G.H5.19
Hydrophobic TM7 T 297 7x57 G.H5 F 354 G.H5.26
Van-der-waals TM7 T 297 7x57 G.H5 F 354 G.H5.26
Hydrophobic ICL2 I 123 34x51 G.H5 F 336 G.H5.08
Hydrophobic ICL2 P 122 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM6 V 226 6x30 G.H5 K 345 G.H5.17
Hydrophobic TM6 A 230 6x34 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 230 6x34 G.H5 L 353 G.H5.25
Hydrophobic TM6 R 229 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM6 V 226 6x30 G.H5 F 354 G.H5.26
Van-der-waals TM6 V 226 6x30 G.H5 F 354 G.H5.26
Polar TM7 T 297 7x57 G.H5 G 352 G.H5.24
Hydrophobic TM7 T 297 7x57 G.H5 G 352 G.H5.24
Van-der-waals TM7 T 297 7x57 G.H5 G 352 G.H5.24
Hydrophobic ICL2 P 122 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 122 34x50 G.H5 I 344 G.H5.16
Polar ICL3 R 222 - G.S6 I 319 G.S6.01
Hydrophobic ICL3 R 222 - G.S6 I 319 G.S6.01
Van-der-waals ICL3 R 222 - G.S6 I 319 G.S6.01
Polar TM6 N 223 6x27 G.H5 D 341 G.H5.13
Hydrophobic TM6 N 223 6x27 G.H5 K 345 G.H5.17
Hydrophobic TM6 M 233 6x37 G.H5 F 354 G.H5.26
Van-der-waals TM6 M 233 6x37 G.H5 F 354 G.H5.26
Hydrophobic TM6 M 233 6x37 G.H5 L 353 G.H5.25
Hydrophobic ICL2 A 126 34x54 G.H5 I 343 G.H5.15
Hydrophobic TM6 V 234 6x38 G.H5 L 353 G.H5.25
Polar TM3 R 115 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 115 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 115 3x50 G.H5 C 351 G.H5.23
Polar ICL3 R 222 - G.S6 Y 320 G.S6.02
Aromatic ICL3 R 222 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 R 222 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 R 222 - G.S6 Y 320 G.S6.02
Hydrophobic ICL2 A 126 34x54 G.H5 N 347 G.H5.19
Hydrophobic TM3 R 115 3x50 G.H5 L 353 G.H5.25
Aromatic H8 R 301 8x51 G.H5 F 354 G.H5.26
Van-der-waals H8 R 301 8x51 G.H5 F 354 G.H5.26
Polar TM3 A 118 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 118 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 118 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM6 V 226 6x30 G.H5 L 348 G.H5.20
Ionic ICL3 R 222 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 R 222 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 R 222 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 R 222 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 I 123 34x51 G.H5 T 340 G.H5.12