S1P4 receptor (s1pr4_mouse)
FAMILY
Class A (Rhodopsin) Lipid receptors Lysophospholipid (S1P) receptors S1P4 receptor
GENE
S1pr4 (Edg6, Lpc1, S1p4)
ORGANISM
Mouse (Mus musculus)
ALT. NAMES
Sphingosine 1-phosphate receptor 4, S1P receptor 4, S1P4, Endothelial differentiation G-protein coupled receptor 6, Lysophospholipid receptor C1, Sphingosine 1-phosphate receptor Edg-6, S1P receptor Edg-6
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
N
|
I
|
S
|
T
|
W
|
S
|
T
|
L
|
V
|
10 |
T
|
P
|
E
|
S
|
C
|
H
|
R
|
L
|
A
|
A
|
20 |
S
|
G
|
H
|
S
|
L
|
L
|
I
|
V
|
L
|
H
|
30 |
Y
|
N
|
H
|
S
|
G
|
R
|
L
|
A
|
S
|
R
|
40 |
TM1 | |||||||||
G
|
G
|
S
|
E
|
D
|
G
|
G
|
G
|
L
|
G
|
50 |
M
|
L
|
R
|
G
|
P
|
S
|
V
|
A
|
A
|
G
|
60 |
C
|
L
|
V
|
V
|
L
|
E
|
N
|
A
|
M
|
V
|
70 |
L
|
A
|
A
|
I
|
A
|
I
|
Y
|
M
|
R
|
S
|
80 |
ICL1 | TM2 | ||||||||
R
|
R
|
W
|
V
|
Y
|
Y
|
C
|
L
|
L
|
N
|
90 |
I
|
T
|
L
|
S
|
D
|
L
|
L
|
T
|
G
|
L
|
100 |
A
|
Y
|
V
|
V
|
N
|
V
|
L
|
L
|
S
|
G
|
110 |
ECL1 | TM3 | ||||||||
T
|
R
|
T
|
F
|
Q
|
L
|
S
|
P
|
V
|
H
|
120 |
W
|
F
|
L
|
R
|
E
|
G
|
L
|
L
|
F
|
M
|
130 |
A
|
L
|
A
|
A
|
S
|
T
|
F
|
S
|
L
|
L
|
140 |
F
|
T
|
A
|
G
|
E
|
R
|
F
|
A
|
T
|
M
|
150 |
ICL2 | |||||||||
V
|
R
|
V
|
A
|
E
|
S
|
G
|
A
|
T
|
K
|
160 |
TM4 | |||||||||
T
|
S
|
R
|
V
|
Y
|
G
|
C
|
I
|
G
|
L
|
170 |
C
|
W
|
L
|
L
|
A
|
A
|
I
|
L
|
G
|
L
|
180 |
ECL2 | |||||||||
L
|
P
|
L
|
L
|
G
|
W
|
N
|
C
|
V
|
C
|
190 |
A
|
F
|
P
|
R
|
C
|
S
|
S
|
L
|
L
|
P
|
200 |
TM5 | |||||||||
L
|
Y
|
S
|
K
|
G
|
Y
|
V
|
L
|
F
|
C
|
210 |
V
|
V
|
V
|
F
|
A
|
L
|
I
|
L
|
V
|
A
|
220 |
I
|
L
|
S
|
L
|
Y
|
G
|
A
|
I
|
F
|
R
|
230 |
ICL3 | |||||||||
V
|
V
|
R
|
A
|
N
|
G
|
Q
|
K
|
S
|
P
|
240 |
TM6 | |||||||||
R
|
P
|
P
|
A
|
R
|
R
|
K
|
S
|
R
|
R
|
250 |
L
|
L
|
N
|
T
|
V
|
L
|
M
|
I
|
L
|
V
|
260 |
A
|
F
|
V
|
V
|
C
|
W
|
G
|
P
|
L
|
F
|
270 |
G
|
L
|
L
|
L
|
A
|
D
|
I
|
F
|
G
|
S
|
280 |
ECL3 | TM7 | ||||||||
N
|
V
|
W
|
A
|
Q
|
E
|
Y
|
L
|
R
|
G
|
290 |
M
|
D
|
W
|
I
|
L
|
A
|
L
|
A
|
V
|
F
|
300 |
N
|
S
|
A
|
I
|
N
|
P
|
L
|
I
|
Y
|
S
|
310 |
H8 | |||||||||
F
|
R
|
S
|
R
|
E
|
V
|
Q
|
R
|
A
|
V
|
320 |
L
|
A
|
F
|
L
|
C
|
C
|
G
|
C
|
L
|
W
|
330 |
C-term | |||||||||
L
|
G
|
L
|
R
|
G
|
P
|
G
|
D
|
C
|
L
|
340 |
T
|
R
|
I
|
T
|
E
|
A
|
H
|
S
|
G
|
A
|
350 |
S
|
T
|
T
|
D
|
S
|
S
|
L
|
R
|
P
|
R
|
360 |
D
|
S
|
F
|
R
|
T
|
S
|
R
|
S
|
L
|
S
|
370 |
F
|
R
|
M
|
R
|
E
|
P
|
L
|
S
|
S
|
I
|
380 |
S
|
S
|
V
|
R
|
S
|
T
|
LINKS
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
sphingosine 1-phosphate
STRUCTURE MODELS
No structure models available. Check the Archive on Structure models for earlier releases.
STRUCTURES
No structures available