apelin receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.5 Å

REFERENCE

PUBLICATION DATE

Jan. 22, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

apelin-13 (Human) - Agonist pubchem gtoplig chembl_ligand uniprot uniprot uniprot

PHYSIOLOGICAL LIGANDS

apelin receptor early endogenous ligand (Mouse), apelin receptor early endogenous ligand (Human), apelin-13 (Human), apelin-17 (Human), Elabela/Toddler-11 (Human), Elabela/Toddler-21 (Human), apelin-36 (Mouse), [Pyr1]apelin-13 (Human), apelin-36 (Human), Elabela/Toddler-32 (Human)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Hydrophobic H8 P 314 8x48 G.H5 L 353 G.H5.25
Hydrophobic TM6 L 246 6x33 G.H5 L 353 G.H5.25
Polar ICL2 P 134 - G.H5 N 347 G.H5.19
Hydrophobic TM3 I 131 3x54 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 127 3x50 G.H5 G 352 G.H5.24
Ionic ICL3 K 234 - G.H5 D 341 G.H5.13
Polar ICL3 K 234 - G.H5 D 341 G.H5.13
Hydrophobic TM5 F 232 5x69 G.H5 F 354 G.H5.26
Hydrophobic TM6 E 238 6x25 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 E 238 6x25 G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL2 V 135 - G.H5 I 343 G.H5.15
Hydrophobic TM3 R 127 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 127 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM5 I 228 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM4 L 142 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 L 142 4x38 G.HN E 28 G.HN.52
Hydrophobic ICL2 V 135 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 V 135 - G.S3 L 194 G.S3.01
Hydrophobic TM3 I 131 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM5 H 231 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 H 231 5x68 G.H5 I 344 G.H5.16
Hydrophobic H8 P 314 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 P 314 8x48 G.H5 F 354 G.H5.26
Hydrophobic TM3 A 130 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 130 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM6 L 246 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 L 246 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM7 F 312 7x56 G.H5 L 353 G.H5.25
Van-der-waals TM7 F 312 7x56 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 131 3x54 G.H5 C 351 G.H5.23
Polar TM3 A 130 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 130 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 130 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 134 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 134 - G.H5 I 343 G.H5.15
Ionic ICL2 R 141 - G.H5 D 350 G.H5.22
Polar ICL2 R 141 - G.H5 D 350 G.H5.22
Van-der-waals ICL2 R 141 - G.H5 D 350 G.H5.22
Hydrophobic ICL2 P 134 - G.H5 T 340 G.H5.12
Van-der-waals ICL2 P 134 - G.H5 T 340 G.H5.12
Aromatic TM5 F 232 5x69 G.H5 K 345 G.H5.17
Hydrophobic TM5 F 232 5x69 G.H5 K 345 G.H5.17
Van-der-waals TM5 F 232 5x69 G.H5 K 345 G.H5.17
Hydrophobic TM6 I 249 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM6 L 246 6x33 G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 134 - G.H5 I 344 G.H5.16
Hydrophobic TM5 F 232 5x69 G.H5 L 348 G.H5.20
Van-der-waals TM5 F 232 5x69 G.H5 L 348 G.H5.20
Hydrophobic TM6 K 242 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 242 6x29 G.H5 F 354 G.H5.26
Hydrophobic H8 D 313 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 D 313 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM3 R 127 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 127 3x50 G.H5 C 351 G.H5.23