NPFF2 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.5 Å

REFERENCE

PUBLICATION DATE

July 23, 2025

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

neuropeptide FF (Human) - Agonist pubchem gtoplig chembl_ligand uniprot uniprot uniprot

PHYSIOLOGICAL LIGANDS

QRFP43 (43RFa) (Human), neuropeptide AF (Rat), neuropeptide AF (Human), RFRP-3 (Human), neuropeptide SF (Human), PrRP-31 (Human), neuropeptide AF (Mouse), neuropeptide FF (Human), RFRP-1 (Human)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Hydrophobic H8 N 439 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 N 439 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM6 I 374 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 374 6x33 G.H5 L 353 G.H5.25
Polar H8 N 441 8x49 G.H5 D 350 G.H5.22
Hydrophobic ICL2 P 252 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 252 - G.H5 I 343 G.H5.15
Hydrophobic ICL2 F 253 - G.H5 F 336 G.H5.08
Hydrophobic TM3 R 245 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 245 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL2 F 253 - G.H5 T 340 G.H5.12
Van-der-waals ICL2 F 253 - G.H5 T 340 G.H5.12
Polar TM2 T 182 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 182 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 T 182 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM3 C 248 3x53 G.H5 C 351 G.H5.23
Polar ICL2 K 256 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 K 256 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 K 256 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 252 - G.H5 I 344 G.H5.16
Polar TM3 C 248 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 C 248 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 C 248 3x53 G.H5 N 347 G.H5.19
Ionic ICL2 K 256 - G.H5 D 350 G.H5.22
Polar ICL2 K 256 - G.H5 D 350 G.H5.22
Hydrophobic ICL2 K 256 - G.H5 D 350 G.H5.22
Hydrophobic TM6 L 378 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM6 I 374 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 I 374 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM2 T 182 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 T 182 2x39 G.H5 D 350 G.H5.22
Hydrophobic ICL2 P 255 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 P 255 - G.hns1 R 32 G.hns1.03
Hydrophobic H8 E 440 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 E 440 8x48 G.H5 F 354 G.H5.26
Polar ICL2 P 252 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 252 - G.H5 N 347 G.H5.19
Hydrophobic TM3 R 245 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 245 3x50 G.H5 C 351 G.H5.23
Polar H8 N 441 8x49 G.H5 K 349 G.H5.21
Hydrophobic TM6 M 377 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL2 F 253 - G.H5 I 343 G.H5.15
Polar H8 E 440 8x48 G.H5 G 352 G.H5.24
Van-der-waals H8 E 440 8x48 G.H5 G 352 G.H5.24
Hydrophobic TM3 V 249 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 249 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM5 L 348 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM6 K 370 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 370 6x29 G.H5 F 354 G.H5.26
Ionic TM6 K 371 6x30 G.H5 D 341 G.H5.13
Polar TM6 K 371 6x30 G.H5 D 341 G.H5.13
Van-der-waals TM6 K 371 6x30 G.H5 D 341 G.H5.13
Hydrophobic H8 N 441 8x49 G.H5 G 352 G.H5.24
Van-der-waals H8 N 441 8x49 G.H5 G 352 G.H5.24
Polar TM6 K 370 6x29 G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL2 F 253 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 F 253 - G.S3 L 194 G.S3.01