PDB
9M1O
Resolution
2.5 Å
Released
July 23, 2025
Receptor
NPFF2
Class
A
Species
Homo sapiens
Ligand
neuropeptide FF (Human)
Function
Agonist
Reference
10.1016/J.CELREP.2025.116160

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
neuropeptide FF (Human) V137 N-term hydrophobic
neuropeptide FF (Human) L141 N-term hydrophobic
neuropeptide FF (Human) C200 2.57x56 TM2 polar (hydrogen bond)
neuropeptide FF (Human) D207 2.64x63 TM2 polar (charge-assisted hydrogen bond)
neuropeptide FF (Human) N208 2.65x64 TM2 Van der Waals
neuropeptide FF (Human) A211 ECL1 Van der Waals
neuropeptide FF (Human) A211 ECL1 hydrophobic
neuropeptide FF (Human) Q227 3.32x32 TM3 polar (hydrogen bond)
neuropeptide FF (Human) V231 3.36x36 TM3 Van der Waals
neuropeptide FF (Human) V231 3.36x36 TM3 hydrophobic
neuropeptide FF (Human) M277 4.57x57 TM4 hydrophobic
neuropeptide FF (Human) Y292 ECL2 Van der Waals
neuropeptide FF (Human) Y292 ECL2 aromatic (face-to-face)
neuropeptide FF (Human) W307 ECL2 Van der Waals
neuropeptide FF (Human) W307 ECL2 hydrophobic
neuropeptide FF (Human) C308 45.50x50 ECL2 Van der Waals
neuropeptide FF (Human) C308 45.50x50 ECL2 polar (hydrogen bond with backbone)
neuropeptide FF (Human) R309 45.51x51 ECL2 Van der Waals
neuropeptide FF (Human) R318 5.35x36 TM5 polar (charge-assisted hydrogen bond)
neuropeptide FF (Human) T322 5.39x40 TM5 Van der Waals
neuropeptide FF (Human) T322 5.39x40 TM5 polar (hydrogen bond)
neuropeptide FF (Human) W393 6.52x52 TM6 Van der Waals
neuropeptide FF (Human) W393 6.52x52 TM6 hydrophobic
neuropeptide FF (Human) M396 6.55x55 TM6 hydrophobic
neuropeptide FF (Human) M396 6.55x55 TM6 Van der Waals
neuropeptide FF (Human) Q410 7.28x27 TM7 polar (hydrogen bond)
neuropeptide FF (Human) Q410 7.28x27 TM7 Van der Waals
neuropeptide FF (Human) N413 7.31x30 TM7 polar (hydrogen bond)
neuropeptide FF (Human) N413 7.31x30 TM7 Van der Waals
neuropeptide FF (Human) Y417 7.35x34 TM7 hydrophobic
neuropeptide FF (Human) Y417 7.35x34 TM7 Van der Waals
neuropeptide FF (Human) H421 7.39x38 TM7 polar (hydrogen bond)
neuropeptide FF (Human) H421 7.39x38 TM7 Van der Waals

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 K H M H ICL1ECL1 G W P F ECL1ICL2 P F K P K L ICL2ECL2 H V Q E E K Y Y R V R L N S Q N K T S P V Y W C R E D W P N Q ECL2ICL3 G R K N Q E Q W ICL3ECL3 D L S P N E L ECL3N-term M N S F F G T P A A S W C L L E S D V S S A P D K E A G R E R R A L S V Q Q R G G P A W S G S L E W S R Q S A G D R R R L G L S R Q T A K S S W S R S R D R T C C C R R A W W I L V P A A D R A R R E R F I M N E K W D T N S S E N W H P I W N V N D T K H H L Y S D I N I T Y V N Y Y L H Q P Q V N-termC-term Q K R A K P M E A Y A L K A K S H V L I N T S N Q L V Q E S T F Q N P H G E T L L Y R K S A E K P Q Q E L V M E E L K E T T N S S E I C-term A A I F I I S Y F L I F F L C M M G N T V V C F I V M R N T V T N L F I L N L A I S D L L V G I F C M P I T L L D N I I A G N T M C K I S G L V Q G I S V A A S V F T L V A I A V D R F Q C V V Y T I K T A F V I I M I I W V L A I T I M S P S A V M L E M R K I Y T T V L F A N I Y L A P L S L I V I M Y G R I G I S L F R A A V P H T H V V S R K K Q K I I K M L L I V A L L F I L S W L P L W T L M M L S D Y A Q I I N I Y I Y P F A H W L A F G N S S V N P I I Y G F F N E N F Q E Q L C F R R G A F Q L
Helix box plot — Download: PNG | SVG T N G M M C L F F I L F Y S I I F I A A 1 L N L A I S D L L V G F I C M P I T L L D 2 A V L T F V S A A V S I G Q V L G S I K 3 A F V I I M I I W V L A I T I M S P S 4 Y M I V I L S L P A L Y I N A F L V T T Y 5 L I V A L L F I L S W L P L W T L M M L 6 I P N V S S N G F A L W H A F P Y I Y 7

GPCRdb(A)
GPCRdb(A)
NPFF2 receptor
TM2
2x56 2.57x56 C200
2x63 2.64x63 D207
2x64 2.65x64 N208
TM3
3x32 3.32x32 Q227
3x36 3.36x36 V231
TM4
4x57 4.57x57 M277
ECL2
45x50 45.50x50 C308
45x51 45.51x51 R309
TM5
5x36 5.35x36 R318
5x40 5.39x40 T322
TM6
6x52 6.52x52 W393
6x55 6.55x55 M396
TM7
7x27 7.28x27 Q410
7x30 7.31x30 N413
7x34 7.35x34 Y417
7x38 7.39x38 H421