PAR3 (par3_human)
FAMILY
Class A (Rhodopsin) Peptide receptors Proteinase-activated receptors PAR3
GENE
F2RL2 (PAR3)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Proteinase-activated receptor 3, PAR-3, Coagulation factor II receptor-like 2, Thrombin receptor-like 2
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
K
|
A
|
L
|
I
|
F
|
A
|
A
|
A
|
G
|
10 |
L
|
L
|
L
|
L
|
L
|
P
|
T
|
F
|
C
|
Q
|
20 |
S
|
G
|
M
|
E
|
N
|
D
|
T
|
N
|
N
|
L
|
30 |
A
|
K
|
P
|
T
|
L
|
P
|
I
|
K
|
T
|
F
|
40 |
R
|
G
|
A
|
P
|
P
|
N
|
S
|
F
|
E
|
E
|
50 |
F
|
P
|
F
|
S
|
A
|
L
|
E
|
G
|
W
|
T
|
60 |
G
|
A
|
T
|
I
|
T
|
V
|
K
|
I
|
K
|
C
|
70 |
P
|
E
|
E
|
S
|
A
|
S
|
H
|
L
|
H
|
V
|
80 |
K
|
N
|
A
|
T
|
M
|
G
|
Y
|
L
|
T
|
S
|
90 |
TM1 | |||||||||
S
|
L
|
S
|
T
|
K
|
L
|
I
|
P
|
A
|
I
|
100 |
Y
|
L
|
L
|
V
|
F
|
V
|
V
|
G
|
V
|
P
|
110 |
A
|
N
|
A
|
V
|
T
|
L
|
W
|
M
|
L
|
F
|
120 |
ICL1 | TM2 | ||||||||
F
|
R
|
T
|
R
|
S
|
I
|
C
|
T
|
T
|
V
|
130 |
F
|
Y
|
T
|
N
|
L
|
A
|
I
|
A
|
D
|
F
|
140 |
L
|
F
|
C
|
V
|
T
|
L
|
P
|
F
|
K
|
I
|
150 |
ECL1 | |||||||||
A
|
Y
|
H
|
L
|
N
|
G
|
N
|
N
|
W
|
V
|
160 |
TM3 | |||||||||
F
|
G
|
E
|
V
|
L
|
C
|
R
|
A
|
T
|
T
|
170 |
V
|
I
|
F
|
Y
|
G
|
N
|
M
|
Y
|
C
|
S
|
180 |
I
|
L
|
L
|
L
|
A
|
C
|
I
|
S
|
I
|
N
|
190 |
R
|
Y
|
L
|
A
|
I
|
V
|
H
|
P
|
F
|
T
|
200 |
ICL2 | TM4 | ||||||||
Y
|
R
|
G
|
L
|
P
|
K
|
H
|
T
|
Y
|
A
|
210 |
L
|
V
|
T
|
C
|
G
|
L
|
V
|
W
|
A
|
T
|
220 |
V
|
F
|
L
|
Y
|
M
|
L
|
P
|
F
|
F
|
I
|
230 |
ECL2 | |||||||||
L
|
K
|
Q
|
E
|
Y
|
Y
|
L
|
V
|
Q
|
P
|
240 |
D
|
I
|
T
|
T
|
C
|
H
|
D
|
V
|
H
|
N
|
250 |
T
|
C
|
E
|
S
|
S
|
S
|
P
|
F
|
Q
|
L
|
260 |
TM5 | |||||||||
Y
|
Y
|
F
|
I
|
S
|
L
|
A
|
F
|
F
|
G
|
270 |
F
|
L
|
I
|
P
|
F
|
V
|
L
|
I
|
I
|
Y
|
280 |
C
|
Y
|
A
|
A
|
I
|
I
|
R
|
T
|
L
|
N
|
290 |
ICL3 | TM6 | ||||||||
A
|
Y
|
D
|
H
|
R
|
W
|
L
|
W
|
Y
|
V
|
300 |
K
|
A
|
S
|
L
|
L
|
I
|
L
|
V
|
I
|
F
|
310 |
T
|
I
|
C
|
F
|
A
|
P
|
S
|
N
|
I
|
I
|
320 |
L
|
I
|
I
|
H
|
H
|
A
|
N
|
Y
|
Y
|
Y
|
330 |
ECL3 | TM7 | ||||||||
N
|
N
|
T
|
D
|
G
|
L
|
Y
|
F
|
I
|
Y
|
340 |
L
|
I
|
A
|
L
|
C
|
L
|
G
|
S
|
L
|
N
|
350 |
S
|
C
|
L
|
D
|
P
|
F
|
L
|
Y
|
F
|
L
|
360 |
C-term | |||||||||
M
|
S
|
K
|
T
|
R
|
N
|
H
|
S
|
T
|
A
|
370 |
Y
|
L
|
T
|
K
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
thrombin
STRUCTURE MODELS
STRUCTURES
No structures available