Y1 receptor (npy1r_human)
FAMILY
Class A (Rhodopsin) Peptide receptors Neuropeptide Y receptors Y1 receptor
GENE
NPY1R (NPYR, NPYY1)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Neuropeptide Y receptor type 1, NPY1-R
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
N
|
S
|
T
|
L
|
F
|
S
|
Q
|
V
|
E
|
10 |
N
|
H
|
S
|
V
|
H
|
S
|
N
|
F
|
S
|
E
|
20 |
K
|
N
|
A
|
Q
|
L
|
L
|
A
|
F
|
E
|
N
|
30 |
TM1 | |||||||||
D
|
D
|
C
|
H
|
L
|
P
|
L
|
A
|
M
|
I
|
40 |
F
|
T
|
L
|
A
|
L
|
A
|
Y
|
G
|
A
|
V
|
50 |
I
|
I
|
L
|
G
|
V
|
S
|
G
|
N
|
L
|
A
|
60 |
L
|
I
|
I
|
I
|
I
|
L
|
K
|
Q
|
K
|
E
|
70 |
ICL1 | TM2 | ||||||||
M
|
R
|
N
|
V
|
T
|
N
|
I
|
L
|
I
|
V
|
80 |
N
|
L
|
S
|
F
|
S
|
D
|
L
|
L
|
V
|
A
|
90 |
I
|
M
|
C
|
L
|
P
|
F
|
T
|
F
|
V
|
Y
|
100 |
ECL1 | |||||||||
T
|
L
|
M
|
D
|
H
|
W
|
V
|
F
|
G
|
E
|
110 |
TM3 | |||||||||
A
|
M
|
C
|
K
|
L
|
N
|
P
|
F
|
V
|
Q
|
120 |
C
|
V
|
S
|
I
|
T
|
V
|
S
|
I
|
F
|
S
|
130 |
L
|
V
|
L
|
I
|
A
|
V
|
E
|
R
|
H
|
Q
|
140 |
ICL2 | |||||||||
L
|
I
|
I
|
N
|
P
|
R
|
G
|
W
|
R
|
P
|
150 |
TM4 | |||||||||
N
|
N
|
R
|
H
|
A
|
Y
|
V
|
G
|
I
|
A
|
160 |
V
|
I
|
W
|
V
|
L
|
A
|
V
|
A
|
S
|
S
|
170 |
L
|
P
|
F
|
L
|
I
|
Y
|
Q
|
V
|
M
|
T
|
180 |
ECL2 | |||||||||
D
|
E
|
P
|
F
|
Q
|
N
|
V
|
T
|
L
|
D
|
190 |
A
|
Y
|
K
|
D
|
K
|
Y
|
V
|
C
|
F
|
D
|
200 |
TM5 | |||||||||
Q
|
F
|
P
|
S
|
D
|
S
|
H
|
R
|
L
|
S
|
210 |
Y
|
T
|
T
|
L
|
L
|
L
|
V
|
L
|
Q
|
Y
|
220 |
F
|
G
|
P
|
L
|
C
|
F
|
I
|
F
|
I
|
C
|
230 |
Y
|
F
|
K
|
I
|
Y
|
I
|
R
|
L
|
K
|
R
|
240 |
ICL3 | |||||||||
R
|
N
|
N
|
M
|
M
|
D
|
K
|
M
|
R
|
D
|
250 |
TM6 | |||||||||
N
|
K
|
Y
|
R
|
S
|
S
|
E
|
T
|
K
|
R
|
260 |
I
|
N
|
I
|
M
|
L
|
L
|
S
|
I
|
V
|
V
|
270 |
A
|
F
|
A
|
V
|
C
|
W
|
L
|
P
|
L
|
T
|
280 |
I
|
F
|
N
|
T
|
V
|
F
|
D
|
W
|
N
|
H
|
290 |
ECL3 | TM7 | ||||||||
Q
|
I
|
I
|
A
|
T
|
C
|
N
|
H
|
N
|
L
|
300 |
L
|
F
|
L
|
L
|
C
|
H
|
L
|
T
|
A
|
M
|
310 |
I
|
S
|
T
|
C
|
V
|
N
|
P
|
I
|
F
|
Y
|
320 |
H8 | |||||||||
G
|
F
|
L
|
N
|
K
|
N
|
F
|
Q
|
R
|
D
|
330 |
L
|
Q
|
F
|
F
|
F
|
N
|
F
|
C
|
D
|
F
|
340 |
C-term | |||||||||
R
|
S
|
R
|
D
|
D
|
D
|
Y
|
E
|
T
|
I
|
350 |
A
|
M
|
S
|
T
|
M
|
H
|
T
|
D
|
V
|
S
|
360 |
K
|
T
|
S
|
L
|
K
|
Q
|
A
|
S
|
P
|
V
|
370 |
A
|
F
|
K
|
K
|
I
|
N
|
N
|
N
|
D
|
D
|
380 |
N
|
E
|
K
|
I
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
peptide YY, pancreatic polypeptide, neuropeptide Y
STRUCTURE MODELS
STRUCTURES
Found 4 structure(s) - view all details on the Structures page