MCH1 receptor (mchr1_human)
FAMILY
Class A (Rhodopsin) Peptide receptors Melanin-concentrating hormone MCH1 receptor
GENE
MCHR1 (GPR24, SLC1)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Melanin-concentrating hormone receptor 1, MCH receptor 1, MCH-R1, MCHR-1, G-protein coupled receptor 24, MCH-1R, MCH1R, MCHR, SLC-1, Somatostatin receptor-like protein
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
S
|
V
|
G
|
A
|
M
|
K
|
K
|
G
|
V
|
10 |
G
|
R
|
A
|
V
|
G
|
L
|
G
|
G
|
G
|
S
|
20 |
G
|
C
|
Q
|
A
|
T
|
E
|
E
|
D
|
P
|
L
|
30 |
P
|
N
|
C
|
G
|
A
|
C
|
A
|
P
|
G
|
Q
|
40 |
G
|
G
|
R
|
R
|
W
|
R
|
L
|
P
|
Q
|
P
|
50 |
A
|
W
|
V
|
E
|
G
|
S
|
S
|
A
|
R
|
L
|
60 |
W
|
E
|
Q
|
A
|
T
|
G
|
T
|
G
|
W
|
M
|
70 |
D
|
L
|
E
|
A
|
S
|
L
|
L
|
P
|
T
|
G
|
80 |
P
|
N
|
A
|
S
|
N
|
T
|
S
|
D
|
G
|
P
|
90 |
D
|
N
|
L
|
T
|
S
|
A
|
G
|
S
|
P
|
P
|
100 |
TM1 | |||||||||
R
|
T
|
G
|
S
|
I
|
S
|
Y
|
I
|
N
|
I
|
110 |
I
|
M
|
P
|
S
|
V
|
F
|
G
|
T
|
I
|
C
|
120 |
L
|
L
|
G
|
I
|
I
|
G
|
N
|
S
|
T
|
V
|
130 |
I
|
F
|
A
|
V
|
V
|
K
|
K
|
S
|
K
|
L
|
140 |
ICL1 | TM2 | ||||||||
H
|
W
|
C
|
N
|
N
|
V
|
P
|
D
|
I
|
F
|
150 |
I
|
I
|
N
|
L
|
S
|
V
|
V
|
D
|
L
|
L
|
160 |
F
|
L
|
L
|
G
|
M
|
P
|
F
|
M
|
I
|
H
|
170 |
ECL1 | |||||||||
Q
|
L
|
M
|
G
|
N
|
G
|
V
|
W
|
H
|
F
|
180 |
TM3 | |||||||||
G
|
E
|
T
|
M
|
C
|
T
|
L
|
I
|
T
|
A
|
190 |
M
|
D
|
A
|
N
|
S
|
Q
|
F
|
T
|
S
|
T
|
200 |
Y
|
I
|
L
|
T
|
A
|
M
|
A
|
I
|
D
|
R
|
210 |
ICL2 | |||||||||
Y
|
L
|
A
|
T
|
V
|
H
|
P
|
I
|
S
|
S
|
220 |
TM4 | |||||||||
T
|
K
|
F
|
R
|
K
|
P
|
S
|
V
|
A
|
T
|
230 |
L
|
V
|
I
|
C
|
L
|
L
|
W
|
A
|
L
|
S
|
240 |
F
|
I
|
S
|
I
|
T
|
P
|
V
|
W
|
L
|
Y
|
250 |
ECL2 | |||||||||
A
|
R
|
L
|
I
|
P
|
F
|
P
|
G
|
G
|
A
|
260 |
V
|
G
|
C
|
G
|
I
|
R
|
L
|
P
|
N
|
P
|
270 |
TM5 | |||||||||
D
|
T
|
D
|
L
|
Y
|
W
|
F
|
T
|
L
|
Y
|
280 |
Q
|
F
|
F
|
L
|
A
|
F
|
A
|
L
|
P
|
F
|
290 |
V
|
V
|
I
|
T
|
A
|
A
|
Y
|
V
|
R
|
I
|
300 |
L
|
Q
|
R
|
M
|
T
|
S
|
S
|
V
|
A
|
P
|
310 |
ICL3 | TM6 | ||||||||
A
|
S
|
Q
|
R
|
S
|
I
|
R
|
L
|
R
|
T
|
320 |
K
|
R
|
V
|
T
|
R
|
T
|
A
|
I
|
A
|
I
|
330 |
C
|
L
|
V
|
F
|
F
|
V
|
C
|
W
|
A
|
P
|
340 |
Y
|
Y
|
V
|
L
|
Q
|
L
|
T
|
Q
|
L
|
S
|
350 |
ECL3 | TM7 | ||||||||
I
|
S
|
R
|
P
|
T
|
L
|
T
|
F
|
V
|
Y
|
360 |
L
|
Y
|
N
|
A
|
A
|
I
|
S
|
L
|
G
|
Y
|
370 |
A
|
N
|
S
|
C
|
L
|
N
|
P
|
F
|
V
|
Y
|
380 |
H8 | |||||||||
I
|
V
|
L
|
C
|
E
|
T
|
F
|
R
|
K
|
R
|
390 |
L
|
V
|
L
|
S
|
V
|
K
|
P
|
A
|
A
|
Q
|
400 |
C-term | |||||||||
G
|
Q
|
L
|
R
|
A
|
V
|
S
|
N
|
A
|
Q
|
410 |
T
|
A
|
D
|
E
|
E
|
R
|
T
|
E
|
S
|
K
|
420 |
G
|
T
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
melanin-concentrating hormone
STRUCTURE MODELS
STRUCTURES
No structures available