5-HT6 receptor (5ht6r_human)
FAMILY
Class A (Rhodopsin) Aminergic receptors 5-Hydroxytryptamine receptors 5-HT6 receptor
GENE
HTR6
ORGANISM
Human (Homo sapiens)
ALT. NAMES
5-hydroxytryptamine receptor 6, 5-HT-6, 5-HT6, Serotonin receptor 6
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
V
|
P
|
E
|
P
|
G
|
P
|
T
|
A
|
N
|
10 |
S
|
T
|
P
|
A
|
W
|
G
|
A
|
G
|
P
|
P
|
20 |
TM1 | |||||||||
S
|
A
|
P
|
G
|
G
|
S
|
G
|
W
|
V
|
A
|
30 |
A
|
A
|
L
|
C
|
V
|
V
|
I
|
A
|
L
|
T
|
40 |
A
|
A
|
A
|
N
|
S
|
L
|
L
|
I
|
A
|
L
|
50 |
ICL1 | |||||||||
I
|
C
|
T
|
Q
|
P
|
A
|
L
|
R
|
N
|
T
|
60 |
TM2 | |||||||||
S
|
N
|
F
|
F
|
L
|
V
|
S
|
L
|
F
|
T
|
70 |
S
|
D
|
L
|
M
|
V
|
G
|
L
|
V
|
V
|
M
|
80 |
P
|
P
|
A
|
M
|
L
|
N
|
A
|
L
|
Y
|
G
|
90 |
ECL1 | TM3 | ||||||||
R
|
W
|
V
|
L
|
A
|
R
|
G
|
L
|
C
|
L
|
100 |
L
|
W
|
T
|
A
|
F
|
D
|
V
|
M
|
C
|
C
|
110 |
S
|
A
|
S
|
I
|
L
|
N
|
L
|
C
|
L
|
I
|
120 |
S
|
L
|
D
|
R
|
Y
|
L
|
L
|
I
|
L
|
S
|
130 |
ICL2 | |||||||||
P
|
L
|
R
|
Y
|
K
|
L
|
R
|
M
|
T
|
P
|
140 |
TM4 | |||||||||
L
|
R
|
A
|
L
|
A
|
L
|
V
|
L
|
G
|
A
|
150 |
W
|
S
|
L
|
A
|
A
|
L
|
A
|
S
|
F
|
L
|
160 |
ECL2 | |||||||||
P
|
L
|
L
|
L
|
G
|
W
|
H
|
E
|
L
|
G
|
170 |
H
|
A
|
R
|
P
|
P
|
V
|
P
|
G
|
Q
|
C
|
180 |
TM5 | |||||||||
R
|
L
|
L
|
A
|
S
|
L
|
P
|
F
|
V
|
L
|
190 |
V
|
A
|
S
|
G
|
L
|
T
|
F
|
F
|
L
|
P
|
200 |
S
|
G
|
A
|
I
|
C
|
F
|
T
|
Y
|
C
|
R
|
210 |
I
|
L
|
L
|
A
|
A
|
R
|
K
|
Q
|
A
|
V
|
220 |
ICL3 | |||||||||
Q
|
V
|
A
|
S
|
L
|
T
|
T
|
G
|
M
|
A
|
230 |
S
|
Q
|
A
|
S
|
E
|
T
|
L
|
Q
|
V
|
P
|
240 |
R
|
T
|
P
|
R
|
P
|
G
|
V
|
E
|
S
|
A
|
250 |
TM6 | |||||||||
D
|
S
|
R
|
R
|
L
|
A
|
T
|
K
|
H
|
S
|
260 |
R
|
K
|
A
|
L
|
K
|
A
|
S
|
L
|
T
|
L
|
270 |
G
|
I
|
L
|
L
|
G
|
M
|
F
|
F
|
V
|
T
|
280 |
W
|
L
|
P
|
F
|
F
|
V
|
A
|
N
|
I
|
V
|
290 |
ECL3 | TM7 | |||||||||
Q
|
A
|
V
|
C
|
D
|
C
|
I
|
S
|
P
|
G
|
|
300 |
L
|
F
|
D
|
V
|
L
|
T
|
W
|
L
|
G
|
Y
|
310 |
C
|
N
|
S
|
T
|
M
|
N
|
P
|
I
|
I
|
Y
|
320 |
H8 | |||||||||
P
|
L
|
F
|
M
|
R
|
D
|
F
|
K
|
R
|
A
|
330 |
L
|
G
|
R
|
F
|
L
|
P
|
C
|
P
|
R
|
C
|
340 |
C-term | |||||||||
P
|
R
|
E
|
R
|
Q
|
A
|
S
|
L
|
A
|
S
|
350 |
P
|
S
|
L
|
R
|
T
|
S
|
H
|
S
|
G
|
P
|
360 |
R
|
P
|
G
|
L
|
S
|
L
|
Q
|
Q
|
V
|
L
|
370 |
P
|
L
|
P
|
L
|
P
|
P
|
D
|
S
|
D
|
S
|
380 |
D
|
S
|
D
|
A
|
G
|
S
|
G
|
G
|
S
|
S
|
390 |
G
|
L
|
R
|
L
|
T
|
A
|
Q
|
L
|
L
|
L
|
400 |
P
|
G
|
E
|
A
|
T
|
Q
|
D
|
P
|
P
|
L
|
410 |
P
|
T
|
R
|
A
|
A
|
A
|
A
|
V
|
N
|
F
|
420 |
F
|
N
|
I
|
D
|
P
|
A
|
E
|
P
|
E
|
L
|
430 |
R
|
P
|
H
|
P
|
L
|
G
|
I
|
P
|
T
|
N
|
440 |
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
5-hydroxytryptamine
STRUCTURE MODELS
STRUCTURES
Found 3 structure(s) - view all details on the Structures page