5-HT6 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7XTB

RESOLUTION

3.3 Å

REFERENCE

10.1016/J.MOLCEL.2022.05.031

PUBLICATION DATE

July 27, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

23 interactions (Click to see)

LIGANDS

5-hydroxytryptamine - Agonist pubchem gtoplig chembl_ligand drugbank

ENDOGENOUS LIGANDS

5-hydroxytryptamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 Q 218 5x68 G.H5 L 388 G.H5.20
Van-der-waals TM5 Q 218 5x68 G.H5 L 388 G.H5.20
Hydrophobic TM3 L 127 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 127 3x53 G.H5 Y 391 G.H5.23
Polar TM6 K 265 6x32 G.H5 L 393 G.H5.25
Hydrophobic TM6 K 265 6x32 G.H5 L 393 G.H5.25
Van-der-waals TM6 K 265 6x32 G.H5 L 393 G.H5.25
Polar TM6 K 265 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 265 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM5 I 211 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 I 211 5x61 G.H5 L 393 G.H5.25
Polar TM5 Q 218 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 Q 218 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 Q 218 5x68 G.H5 Q 384 G.H5.16
Polar TM3 I 128 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 128 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 128 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 128 3x54 G.H5 H 387 G.H5.19
Hydrophobic TM5 V 222 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 V 222 5x72 G.H5 R 385 G.H5.17
Polar H8 R 325 8x48 G.H5 Q 390 G.H5.22
Hydrophobic ICL2 P 131 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 131 34x50 G.H5 I 383 G.H5.15
Polar TM2 S 61 2x39 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 132 34x51 G.H5 I 383 G.H5.15
Ionic H8 K 328 8x51 G.H5 E 392 G.H5.24
Polar H8 K 328 8x51 G.H5 E 392 G.H5.24
Ionic TM6 K 265 6x32 G.H5 E 392 G.H5.24
Polar TM6 K 265 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM6 K 265 6x32 G.H5 E 392 G.H5.24
Van-der-waals TM6 K 265 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM3 I 128 3x54 G.H5 Y 391 G.H5.23
Aromatic TM3 R 124 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 124 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 132 34x51 G.S3 V 217 G.S3.01
Hydrophobic TM3 I 128 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 128 3x54 G.H5 L 388 G.H5.20
Polar ICL2 R 133 34x52 G.s2s3 D 215 G.s2s3.01
Van-der-waals ICL2 R 133 34x52 G.s2s3 D 215 G.s2s3.01
Hydrophobic TM7 F 323 7x56 G.H5 E 392 G.H5.24
Van-der-waals TM7 F 323 7x56 G.H5 E 392 G.H5.24
Hydrophobic ICL2 L 132 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 132 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 P 131 34x50 G.H5 Q 384 G.H5.16
Van-der-waals ICL2 P 131 34x50 G.H5 Q 384 G.H5.16
Hydrophobic TM5 A 215 5x65 G.H5 L 388 G.H5.20
Hydrophobic ICL2 R 133 34x52 G.S3 V 217 G.S3.01
Van-der-waals ICL2 R 133 34x52 G.S3 V 217 G.S3.01
Hydrophobic ICL2 L 132 34x51 G.H5 R 380 G.H5.12
Van-der-waals ICL2 L 132 34x51 G.H5 R 380 G.H5.12
Van-der-waals TM7 F 323 7x56 G.H5 Y 391 G.H5.23
Hydrophobic H8 M 324 8x47 G.H5 Y 391 G.H5.23
Polar H8 D 326 8x49 G.H5 Q 390 G.H5.22
Hydrophobic H8 D 326 8x49 G.H5 Q 390 G.H5.22
Van-der-waals H8 D 326 8x49 G.H5 Q 390 G.H5.22
Polar TM5 Q 221 5x71 G.H5 D 381 G.H5.13
Hydrophobic ICL2 L 132 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 132 34x51 G.H5 F 376 G.H5.08
Ionic H8 R 325 8x48 G.H5 E 392 G.H5.24
Polar H8 R 325 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 R 325 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 R 325 8x48 G.H5 E 392 G.H5.24
Hydrophobic ICL2 P 131 34x50 G.H5 H 387 G.H5.19
Van-der-waals ICL2 P 131 34x50 G.H5 H 387 G.H5.19
Polar ICL3 T 227 - G.h4s6 T 350 G.h4s6.03
Van-der-waals ICL3 T 227 - G.h4s6 T 350 G.h4s6.03
Polar TM3 L 127 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 L 127 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 L 127 3x53 G.H5 H 387 G.H5.19
Polar H8 R 325 8x48 G.H5 L 394 G.H5.26
Hydrophobic TM5 V 222 5x72 G.h4s6 Y 358 G.h4s6.20
Polar TM5 S 224 5x74 G.hgh4 D 323 G.hgh4.13
Polar H8 R 325 8x48 G.H5 R 389 G.H5.21
Hydrophobic H8 R 325 8x48 G.H5 R 389 G.H5.21
Van-der-waals H8 R 325 8x48 G.H5 R 389 G.H5.21
Hydrophobic TM5 L 225 5x75 G.H4 L 346 G.H4.16
Hydrophobic TM6 A 266 6x33 G.H5 L 393 G.H5.25