5-HT6 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.3 Å

REFERENCE

PUBLICATION DATE

July 27, 2022

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

5-hydroxytryptamine - Agonist pubchem gtoplig chembl_ligand drugbank

PHYSIOLOGICAL LIGANDS

5-hydroxytryptamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
D01G.s2s3T03G.h4s6D13Q16R21Q22Y23E24L26G.H5GproteinK6x32I3x54Q5x71Q5x68R8x48K8x51S2x39R34x52T-GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.s2s3G.h4s6G.H5GPCR segments:TM2ICL2TM3ICL3TM5TM6H8

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null2x393x503x533x5434x5034x5134x525x615x655x685x715x725x745x756x326x337x568x478x488x498x51G.H5.26G.H5.25G.H5.24G.H5.23G.H5.22G.H5.21G.H5.20G.H5.19G.H5.17G.H5.16G.H5.15G.H5.13G.H5.12G.H5.08G.h4s6.20G.h4s6.03G.H4.16G.hgh4.13G.S3.01G.s2s3.01G.S1.02Res. Pos.5-HT6 (7XTB)- (7XTB)----------------------SRLIPLRIAQQVSLKAFMRDKSPLRRLIIAQQVSLKAFMRDKTYIQHFRHVDLLDRYDLELRQT

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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