PDB
7XTB
Resolution
3.3 Å
Released
July 27, 2022
Receptor
5-HT6
Class
A
Species
Homo sapiens
Ligand
5-hydroxytryptamine
Function
Agonist
Reference
10.1016/J.MOLCEL.2022.05.031

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Ligand Amino Acid Generic Number Segment Interaction Type
5-hydroxytryptamine V107 3.33x33 TM3 hydrophobic
5-hydroxytryptamine C110 3.36x36 TM3 hydrophobic
5-hydroxytryptamine A192 5.42x43 TM5 hydrophobic
5-hydroxytryptamine F284 6.51x51 TM6 hydrophobic
5-hydroxytryptamine F285 6.52x52 TM6 aromatic (edge-to-face)
5-hydroxytryptamine N288 6.55x55 TM6 polar (hydrogen bond)
5-hydroxytryptamine N288 6.55x55 TM6 Van der Waals

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ICL1 P A L R ICL1ECL1 R W V L ECL1ICL2 P L R Y K L R M ICL2ECL2 W H E L G H A R P P V P G Q C R L L A ECL2ICL3 T G M A S Q A S E T L Q V P R T P R P G V E S A D S R R L A ICL3ECL3 D C I ECL3N-term M V P E P G P T A N S T P A W G A G P P S A P G G N-termC-term P R C P R E R Q A S L A S P S L R T S H S G P R P G L S L Q Q V L P L P L P P D S D S D S D A G S G G S S G L R L T A Q L L L P G E A T Q D P P L P T R A A A A V N F F N I D P A E P E L R P H P L G I P T N C-term S G W V A A A L C V V I A L T A A A N S L L I A L I C T Q N T S N F F L V S L F T S D L M V G L V V M P P A M L N A L Y G A R G L C L L W T A F D V M C C S A S I L N L C L I S L D R Y L L I L S T P L R A L A L V L G A W S L A A L A S F L P L L L G S L P F V L V A S G L T F F L P S G A I C F T Y C R I L L A A R K Q A V Q V A S L T T K H S R K A L K A S L T L G I L L G M F F V T W L P F F V A N I V Q A V C S P G L F D V L T W L G Y C N S T M N P I I Y P L F M R D L G R F K R A F L P C
Helix box plot — Download: PNG | SVG S N A A A T L A I V V C L A A A V W G S 1 V S L F T S D L M V G V L V M P P A M L N 2 L C L N L I S A S C C M V D F A T W L L 3 A L A L V L G A W S L A A L A S F L P L 4 Y T F C I A G S P L F F T L G S A V L V F 5 G I L L G M F F V T W L P F F V A N I V 6 I P N M T S N C Y G L W T L V D F L G 7

GPCRdb(A)
GPCRdb(A)
5-HT6 receptor
TM3
3x33 3.33x33 V107
3x36 3.36x36 C110
TM5
5x43 5.42x43 A192
TM6
6x51 6.51x51 F284
6x52 6.52x52 F285
6x55 6.55x55 N288