5-HT6 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.1 Å

REFERENCE

PUBLICATION DATE

June 28, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

CHEMBL365751 - Agonist chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

5-hydroxytryptamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM5 A 215 5x65 G.H5 L 388 G.H5.20
Hydrophobic H8 M 324 8x47 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 132 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 132 - G.H5 I 383 G.H5.15
Hydrophobic TM6 T 269 6x36 G.H5 L 393 G.H5.25
Hydrophobic TM3 I 128 3x54 G.H5 L 393 G.H5.25
Van-der-waals TM7 F 323 7x56 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 132 - G.H5 C 379 G.H5.11
Polar TM5 Q 218 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 Q 218 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 Q 218 5x68 G.H5 Q 384 G.H5.16
Polar TM6 K 265 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM6 K 265 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 265 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM5 Q 218 5x68 G.H5 L 394 G.H5.26
Polar TM5 Q 218 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM5 I 211 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 I 211 5x61 G.H5 L 393 G.H5.25
Ionic H8 R 325 8x48 G.H5 E 392 G.H5.24
Polar H8 R 325 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 R 325 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 R 325 8x48 G.H5 E 392 G.H5.24
Hydrophobic TM5 Q 218 5x68 G.H5 L 388 G.H5.20
Hydrophobic ICL2 P 131 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 P 131 - G.H5 Q 384 G.H5.16
Hydrophobic ICL2 P 131 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 131 - G.H5 I 383 G.H5.15
Hydrophobic ICL2 L 132 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 132 - G.H5 F 376 G.H5.08
Hydrophobic TM7 F 323 7x56 G.H5 E 392 G.H5.24
Van-der-waals TM7 F 323 7x56 G.H5 E 392 G.H5.24
Hydrophobic TM3 I 128 3x54 G.H5 Y 391 G.H5.23
Polar H8 R 325 8x48 G.H5 R 389 G.H5.21
Hydrophobic H8 R 325 8x48 G.H5 R 389 G.H5.21
Van-der-waals H8 R 325 8x48 G.H5 R 389 G.H5.21
Hydrophobic TM5 V 222 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 V 222 5x72 G.H5 R 385 G.H5.17
Polar TM3 I 128 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 128 3x54 G.H5 Q 384 G.H5.16
Aromatic TM3 R 124 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 124 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 K 135 - G.hns1 A 39 G.hns1.03
Polar H8 R 325 8x48 G.H5 Q 390 G.H5.22
Hydrophobic H8 R 325 8x48 G.H5 Q 390 G.H5.22
Van-der-waals H8 R 325 8x48 G.H5 Q 390 G.H5.22
Hydrophobic TM6 L 270 6x37 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 132 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 132 - G.S1 H 41 G.S1.02
Hydrophobic TM5 L 225 5x75 G.H4 L 346 G.H4.16
Van-der-waals TM5 L 225 5x75 G.H4 L 346 G.H4.16
Hydrophobic TM3 L 127 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 L 127 3x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 K 135 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 K 135 - G.hns1 R 38 G.hns1.02
Polar TM5 Q 218 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM3 I 128 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 128 3x54 G.H5 L 388 G.H5.20
Polar ICL2 R 133 - G.s2s3 D 215 G.s2s3.01
Hydrophobic ICL2 L 132 - G.H5 R 380 G.H5.12
Hydrophobic TM5 L 225 5x75 G.S6 P 361 G.S6.03
Van-der-waals TM5 L 225 5x75 G.S6 P 361 G.S6.03
Hydrophobic TM3 I 128 3x54 G.H5 H 387 G.H5.19
Ionic TM6 K 265 6x32 G.H5 E 392 G.H5.24
Polar TM6 A 266 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 A 266 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 266 6x33 G.H5 L 393 G.H5.25
Polar TM2 S 61 2x39 G.H5 Y 391 G.H5.23