PDB
8JLZ
Resolution
3.1 Å
Released
June 28, 2023
Receptor
5-HT6
Class
A
Species
Homo sapiens
Ligand
CHEMBL365751
Function
Agonist
Reference
10.1016/J.BBRC.2023.05.126

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Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL365751 V107 3.33x33 TM3 hydrophobic
CHEMBL365751 C110 3.36x36 TM3 hydrophobic
CHEMBL365751 F188 5.38x39 TM5 hydrophobic
CHEMBL365751 A192 5.42x43 TM5 hydrophobic
CHEMBL365751 F284 6.51x51 TM6 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 P A L R ICL1ECL1 R W V L ECL1ICL2 P L R Y K L R M ICL2ECL2 W H E L G H A R P P V P G Q C R L L A ECL2ICL3 T G M A S Q A S E T L Q V P R T P R P G V E S A D S R R L A ICL3ECL3 D C I ECL3N-term M V P E P G P T A N S T P A W G A G P P S A P G G N-termC-term P R C P R E R Q A S L A S P S L R T S H S G P R P G L S L Q Q V L P L P L P P D S D S D S D A G S G G S S G L R L T A Q L L L P G E A T Q D P P L P T R A A A A V N F F N I D P A E P E L R P H P L G I P T N C-term S G W V A A A L C V V I A L T A A A N S L L I A L I C T Q N T S N F F L V S L F T S D L M V G L V V M P P A M L N A L Y G A R G L C L L W T A F D V M C C S A S I L N L C L I S L D R Y L L I L S T P L R A L A L V L G A W S L A A L A S F L P L L L G S L P F V L V A S G L T F F L P S G A I C F T Y C R I L L A A R K Q A V Q V A S L T T K H S R K A L K A S L T L G I L L G M F F V T W L P F F V A N I V Q A V C S P G L F D V L T W L G Y C N S T M N P I I Y P L F M R D L G R F K R A F L P C
Helix box plot — Download: PNG | SVG S N A A A T L A I V V C L A A A V W G S 1 V S L F T S D L M V G V L V M P P A M L N 2 L C L N L I S A S C C M V D F A T W L L 3 A L A L V L G A W S L A A L A S F L P L 4 Y T F C I A G S P L F F T L G S A V L V F 5 G I L L G M F F V T W L P F F V A N I V 6 I P N M T S N C Y G L W T L V D F L G 7

GPCRdb(A)
GPCRdb(A)
5-HT6 receptor
TM3
3x33 3.33x33 V107
3x36 3.36x36 C110
TM5
5x39 5.38x39 F188
5x43 5.42x43 A192
TM6
6x51 6.51x51 F284