GPR139 (gp139_human)
FAMILY
Class A (Rhodopsin) Orphan receptors Class A orphans GPR139
GENE
GPR139 (GPRG1, PGR3)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Probable G-protein coupled receptor 139, G(q)-coupled orphan receptor GPRg1, G-protein-coupled receptor PGR3
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
E
|
H
|
T
|
H
|
A
|
H
|
L
|
A
|
A
|
10 |
N
|
S
|
S
|
L
|
S
|
W
|
W
|
S
|
P
|
G
|
20 |
TM1 | |||||||||
S
|
A
|
C
|
G
|
L
|
G
|
F
|
V
|
P
|
V
|
30 |
V
|
Y
|
Y
|
S
|
L
|
L
|
L
|
C
|
L
|
G
|
40 |
L
|
P
|
A
|
N
|
I
|
L
|
T
|
V
|
I
|
I
|
50 |
ICL1 | |||||||||
L
|
S
|
Q
|
L
|
V
|
A
|
R
|
R
|
Q
|
K
|
60 |
TM2 | |||||||||
S
|
S
|
Y
|
N
|
Y
|
L
|
L
|
A
|
L
|
A
|
70 |
A
|
A
|
D
|
I
|
L
|
V
|
L
|
F
|
F
|
I
|
80 |
V
|
F
|
V
|
D
|
F
|
L
|
L
|
E
|
D
|
F
|
90 |
ECL1 | TM3 | ||||||||
I
|
L
|
N
|
M
|
Q
|
M
|
P
|
Q
|
V
|
P
|
100 |
D
|
K
|
I
|
I
|
E
|
V
|
L
|
E
|
F
|
S
|
110 |
S
|
I
|
H
|
T
|
S
|
I
|
W
|
I
|
T
|
V
|
120 |
P
|
L
|
T
|
I
|
D
|
R
|
Y
|
I
|
A
|
V
|
130 |
ICL2 | |||||||||
C
|
H
|
P
|
L
|
K
|
Y
|
H
|
T
|
V
|
S
|
140 |
TM4 | |||||||||
Y
|
P
|
A
|
R
|
T
|
R
|
K
|
V
|
I
|
V
|
150 |
S
|
V
|
Y
|
I
|
T
|
C
|
F
|
L
|
T
|
S
|
160 |
ECL2 | |||||||||
I
|
P
|
Y
|
Y
|
W
|
W
|
P
|
N
|
I
|
W
|
170 |
TM5 | |||||||||
T
|
E
|
D
|
Y
|
I
|
S
|
T
|
S
|
V
|
H
|
180 |
H
|
V
|
L
|
I
|
W
|
I
|
H
|
C
|
F
|
T
|
190 |
V
|
Y
|
L
|
V
|
P
|
C
|
S
|
I
|
F
|
F
|
200 |
I
|
L
|
N
|
S
|
I
|
I
|
V
|
Y
|
K
|
L
|
210 |
ICL3 | |||||||||
R
|
R
|
K
|
S
|
N
|
F
|
R
|
L
|
R
|
G
|
220 |
TM6 | |||||||||
Y
|
S
|
T
|
G
|
K
|
T
|
T
|
A
|
I
|
L
|
230 |
F
|
T
|
I
|
T
|
S
|
I
|
F
|
A
|
T
|
L
|
240 |
W
|
A
|
P
|
R
|
I
|
I
|
M
|
I
|
L
|
Y
|
250 |
ECL3 | |||||||||
H
|
L
|
Y
|
G
|
A
|
P
|
I
|
Q
|
N
|
R
|
260 |
TM7 | |||||||||
W
|
L
|
V
|
H
|
I
|
M
|
S
|
D
|
I
|
A
|
270 |
N
|
M
|
L
|
A
|
L
|
L
|
N
|
T
|
A
|
I
|
280 |
H8 | |||||||||
N
|
F
|
F
|
L
|
Y
|
C
|
F
|
I
|
S
|
K
|
290 |
R
|
F
|
R
|
T
|
M
|
A
|
A
|
A
|
T
|
L
|
300 |
C-term | |||||||||
K
|
A
|
F
|
F
|
K
|
C
|
Q
|
K
|
Q
|
P
|
310 |
V
|
Q
|
F
|
Y
|
T
|
N
|
H
|
N
|
F
|
S
|
320 |
I
|
T
|
S
|
S
|
P
|
W
|
I
|
S
|
P
|
A
|
330 |
N
|
S
|
H
|
C
|
I
|
K
|
M
|
L
|
V
|
Y
|
340 |
Q
|
Y
|
D
|
K
|
N
|
G
|
K
|
P
|
I
|
K
|
350 |
V
|
S
|
P
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
L-phenylalanine, L-tryptophan
STRUCTURE MODELS
STRUCTURES
Found 4 structure(s) - view all details on the Structures page