oxoglutarate receptor (oxgr1_human)
FAMILY
Class A (Rhodopsin) Alicarboxylic acid receptors Oxoglutarate receptors oxoglutarate receptor
GENE
OXGR1 (GPR80, GPR99, P2RY15, P2Y15)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
2-oxoglutarate receptor 1, Alpha-ketoglutarate receptor 1, G-protein coupled receptor 80, G-protein coupled receptor 99, P2Y purinoceptor 15, P2Y15, P2Y-like GPCR, P2Y-like nucleotide receptor
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
N
|
E
|
P
|
L
|
D
|
Y
|
L
|
A
|
N
|
10 |
A
|
S
|
D
|
F
|
P
|
D
|
Y
|
A
|
A
|
A
|
20 |
F
|
G
|
N
|
C
|
T
|
D
|
E
|
N
|
I
|
P
|
30 |
TM1 | |||||||||
L
|
K
|
M
|
H
|
Y
|
L
|
P
|
V
|
I
|
Y
|
40 |
G
|
I
|
I
|
F
|
L
|
V
|
G
|
F
|
P
|
G
|
50 |
N
|
A
|
V
|
V
|
I
|
S
|
T
|
Y
|
I
|
F
|
60 |
ICL1 | TM2 | ||||||||
K
|
M
|
R
|
P
|
W
|
K
|
S
|
S
|
T
|
I
|
70 |
I
|
M
|
L
|
N
|
L
|
A
|
C
|
T
|
D
|
L
|
80 |
L
|
Y
|
L
|
T
|
S
|
L
|
P
|
F
|
L
|
I
|
90 |
ECL1 | |||||||||
H
|
Y
|
Y
|
A
|
S
|
G
|
E
|
N
|
W
|
I
|
100 |
TM3 | |||||||||
F
|
G
|
D
|
F
|
M
|
C
|
K
|
F
|
I
|
R
|
110 |
F
|
S
|
F
|
H
|
F
|
N
|
L
|
Y
|
S
|
S
|
120 |
I
|
L
|
F
|
L
|
T
|
C
|
F
|
S
|
I
|
F
|
130 |
R
|
Y
|
C
|
V
|
I
|
I
|
H
|
P
|
M
|
S
|
140 |
ICL2 | TM4 | ||||||||
C
|
F
|
S
|
I
|
H
|
K
|
T
|
R
|
C
|
A
|
150 |
V
|
V
|
A
|
C
|
A
|
V
|
V
|
W
|
I
|
I
|
160 |
S
|
L
|
V
|
A
|
V
|
I
|
P
|
M
|
T
|
F
|
170 |
ECL2 | |||||||||
L
|
I
|
T
|
S
|
T
|
N
|
R
|
T
|
N
|
R
|
180 |
S
|
A
|
C
|
L
|
D
|
L
|
T
|
S
|
S
|
D
|
190 |
TM5 | |||||||||
E
|
L
|
N
|
T
|
I
|
K
|
W
|
Y
|
N
|
L
|
200 |
I
|
L
|
T
|
A
|
T
|
T
|
F
|
C
|
L
|
P
|
210 |
L
|
V
|
I
|
V
|
T
|
L
|
C
|
Y
|
T
|
T
|
220 |
I
|
I
|
H
|
T
|
L
|
T
|
H
|
G
|
L
|
Q
|
230 |
ICL3 | TM6 | ||||||||
T
|
D
|
S
|
C
|
L
|
K
|
Q
|
K
|
A
|
R
|
240 |
R
|
L
|
T
|
I
|
L
|
L
|
L
|
L
|
A
|
F
|
250 |
Y
|
V
|
C
|
F
|
L
|
P
|
F
|
H
|
I
|
L
|
260 |
R
|
V
|
I
|
R
|
I
|
E
|
S
|
R
|
L
|
L
|
270 |
ECL3 | TM7 | ||||||||
S
|
I
|
S
|
C
|
S
|
I
|
E
|
N
|
Q
|
I
|
280 |
H
|
E
|
A
|
Y
|
I
|
V
|
S
|
R
|
P
|
L
|
290 |
A
|
A
|
L
|
N
|
T
|
F
|
G
|
N
|
L
|
L
|
300 |
H8 | |||||||||
L
|
Y
|
V
|
V
|
V
|
S
|
D
|
N
|
F
|
Q
|
310 |
Q
|
A
|
V
|
C
|
S
|
T
|
V
|
R
|
C
|
K
|
320 |
C-term | |||||||||
V
|
S
|
G
|
N
|
L
|
E
|
Q
|
A
|
K
|
K
|
330 |
I
|
S
|
Y
|
S
|
N
|
N
|
P
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
α-ketoglutaric acid
STRUCTURE MODELS
STRUCTURES
No structures available