EP4 receptor (pe2r4_mouse)
FAMILY
Class A (Rhodopsin) Lipid receptors Prostanoid receptors EP4 receptor
GENE
Ptger4 (Ptgerep4)
ORGANISM
Mouse (Mus musculus)
ALT. NAMES
Prostaglandin E2 receptor EP4 subtype, PGE receptor EP4 subtype, PGE2 receptor EP4 subtype, Prostanoid EP4 receptor
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
A
|
E
|
V
|
G
|
G
|
T
|
I
|
P
|
R
|
10 |
S
|
N
|
R
|
E
|
L
|
Q
|
R
|
C
|
V
|
L
|
20 |
L
|
T
|
T
|
T
|
I
|
M
|
S
|
I
|
P
|
G
|
30 |
V
|
N
|
A
|
S
|
F
|
S
|
S
|
T
|
P
|
E
|
40 |
TM1 | |||||||||
R
|
L
|
N
|
S
|
P
|
V
|
T
|
I
|
P
|
A
|
50 |
V
|
M
|
F
|
I
|
F
|
G
|
V
|
V
|
G
|
N
|
60 |
L
|
V
|
A
|
I
|
V
|
V
|
L
|
C
|
K
|
S
|
70 |
ICL1 | TM2 | ||||||||
R
|
K
|
E
|
Q
|
K
|
E
|
T
|
T
|
F
|
Y
|
80 |
T
|
L
|
V
|
C
|
G
|
L
|
A
|
V
|
T
|
D
|
90 |
L
|
L
|
G
|
T
|
L
|
L
|
V
|
S
|
P
|
V
|
100 |
T
|
I
|
A
|
T
|
Y
|
M
|
K
|
G
|
Q
|
W
|
110 |
ECL1 | TM3 | ||||||||
P
|
G
|
D
|
Q
|
A
|
L
|
C
|
D
|
Y
|
S
|
120 |
T
|
F
|
I
|
L
|
L
|
F
|
F
|
G
|
L
|
S
|
130 |
G
|
L
|
S
|
I
|
I
|
C
|
A
|
M
|
S
|
I
|
140 |
E
|
R
|
Y
|
L
|
A
|
I
|
N
|
H
|
A
|
Y
|
150 |
ICL2 | TM4 | ||||||||
F
|
Y
|
S
|
H
|
Y
|
V
|
D
|
K
|
R
|
L
|
160 |
A
|
G
|
L
|
T
|
L
|
F
|
A
|
I
|
Y
|
A
|
170 |
S
|
N
|
V
|
L
|
F
|
C
|
A
|
L
|
P
|
N
|
180 |
ECL2 | |||||||||
M
|
G
|
L
|
G
|
R
|
S
|
E
|
R
|
Q
|
Y
|
190 |
P
|
G
|
T
|
W
|
C
|
F
|
I
|
D
|
W
|
T
|
200 |
TM5 | |||||||||
T
|
N
|
V
|
T
|
A
|
Y
|
A
|
A
|
F
|
S
|
210 |
Y
|
M
|
Y
|
A
|
G
|
F
|
S
|
S
|
F
|
L
|
220 |
I
|
L
|
A
|
T
|
V
|
L
|
C
|
N
|
V
|
L
|
230 |
V
|
C
|
G
|
A
|
L
|
L
|
R
|
M
|
H
|
R
|
240 |
ICL3 | |||||||||
Q
|
F
|
M
|
R
|
R
|
T
|
S
|
L
|
G
|
T
|
250 |
E
|
Q
|
H
|
H
|
A
|
A
|
A
|
A
|
A
|
A
|
260 |
V
|
A
|
S
|
V
|
A
|
C
|
R
|
G
|
H
|
A
|
270 |
G
|
A
|
S
|
P
|
A
|
L
|
Q
|
R
|
L
|
S
|
280 |
D
|
F
|
R
|
R
|
R
|
R
|
S
|
F
|
R
|
R
|
290 |
TM6 | |||||||||
I
|
A
|
G
|
A
|
E
|
I
|
Q
|
M
|
V
|
I
|
300 |
L
|
L
|
I
|
A
|
T
|
S
|
L
|
V
|
V
|
L
|
310 |
I
|
C
|
S
|
I
|
P
|
L
|
V
|
V
|
R
|
V
|
320 |
ECL3 | |||||||||
F
|
I
|
N
|
Q
|
L
|
Y
|
Q
|
P
|
N
|
V
|
330 |
TM7 | |||||||||
V
|
K
|
D
|
I
|
S
|
R
|
N
|
P
|
D
|
L
|
340 |
Q
|
A
|
I
|
R
|
I
|
A
|
S
|
V
|
N
|
P
|
350 |
I
|
L
|
D
|
P
|
W
|
I
|
Y
|
I
|
L
|
L
|
360 |
H8 | |||||||||
R
|
K
|
T
|
V
|
L
|
S
|
K
|
A
|
I
|
E
|
370 |
C-term | |||||||||
K
|
I
|
K
|
C
|
L
|
F
|
C
|
R
|
I
|
G
|
380 |
G
|
S
|
G
|
R
|
D
|
S
|
S
|
A
|
Q
|
H
|
390 |
C
|
S
|
E
|
S
|
R
|
R
|
T
|
S
|
S
|
A
|
400 |
M
|
S
|
G
|
H
|
S
|
R
|
S
|
F
|
L
|
A
|
410 |
R
|
E
|
L
|
K
|
E
|
I
|
S
|
S
|
T
|
S
|
420 |
Q
|
T
|
L
|
L
|
Y
|
L
|
P
|
D
|
L
|
T
|
430 |
E
|
S
|
S
|
L
|
G
|
G
|
R
|
N
|
L
|
L
|
440 |
P
|
G
|
S
|
H
|
G
|
M
|
G
|
L
|
T
|
Q
|
450 |
A
|
D
|
T
|
T
|
S
|
L
|
R
|
T
|
L
|
R
|
460 |
I
|
S
|
E
|
T
|
S
|
D
|
S
|
S
|
Q
|
G
|
470 |
Q
|
D
|
S
|
E
|
S
|
V
|
L
|
L
|
V
|
D
|
480 |
E
|
V
|
S
|
G
|
S
|
H
|
R
|
E
|
E
|
P
|
490 |
A
|
S
|
K
|
G
|
N
|
S
|
L
|
Q
|
V
|
T
|
500 |
F
|
P
|
S
|
E
|
T
|
L
|
K
|
L
|
S
|
E
|
510 |
K
|
C
|
I
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
PGE2, PGE1
STRUCTURE MODELS
No structure models available. Check the Archive on Structure models for earlier releases.
STRUCTURES
No structures available