C5a2 receptor (c5ar2_human)

FAMILY

Class A (Rhodopsin) Peptide receptors Complement peptide receptors C5a2 receptor

GENE

C5AR2 (C5L2, GPR77)

ORGANISM

Human (Homo sapiens)

ALT. NAMES

C5a anaphylatoxin chemotactic receptor 2, Complement component 5a receptor 2, G-protein coupled receptor 77

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
G
N
D
S
V
S
Y
E
Y
10
                   
G
D
Y
S
D
L
S
D
R
P
20
                   
V
D
C
L
D
G
A
C
L
A
30
  TM1            
I
D
P
L
R
V
A
P
L
P
40
                   
L
Y
A
A
I
F
L
V
G
V
50
                   
P
G
N
A
M
V
A
W
V
A
60
      ICL1 TM2
G
K
V
A
R
R
R
V
G
A
70
                   
T
W
L
L
H
L
A
V
A
D
80
                   
L
L
C
C
L
S
L
P
I
L
90
                   
A
V
P
I
A
R
G
G
H
W
100
ECL1 TM3      
P
Y
G
A
V
G
C
R
A
L
110
                   
P
S
I
I
L
L
T
M
Y
A
120
                   
S
V
L
L
L
A
A
L
S
A
130
                   
D
L
C
F
L
A
L
G
P
A
140
ICL2     TM4  
W
W
S
T
V
Q
R
A
C
G
150
                   
V
Q
V
A
C
G
A
A
W
T
160
                   
L
A
L
L
L
T
V
P
S
A
170
      ECL2      
I
Y
R
R
L
H
Q
E
H
F
180
                   
P
A
R
L
Q
C
V
V
D
Y
190
    TM5          
G
G
S
S
S
T
E
N
A
V
200
                   
T
A
I
R
F
L
F
G
F
L
210
                   
G
P
L
V
A
V
A
S
C
H
220
            ICL3
S
A
L
L
C
W
A
A
R
R
230
TM6              
C
R
P
L
G
T
A
I
V
V
240
                   
G
F
F
V
C
W
A
P
Y
H
250
                   
L
L
G
L
V
L
T
V
A
A
260
ECL3 TM7      
P
N
S
A
L
L
A
R
A
L
270
                   
R
A
E
P
L
I
V
G
L
A
280
                   
L
A
H
S
C
L
N
P
M
L
290
                   
F
L
Y
F
G
R
A
Q
L
R
300
C-term        
R
S
L
P
A
A
C
H
W
A
310
                   
L
R
E
S
Q
G
Q
D
E
S
320
                   
V
D
S
K
K
S
T
S
H
D
330
             
L
V
S
E
M
E
V

LINKS

Guide To Pharmacology

UniProt

DIAGRAMS

7TM

ICL1 A R R ICL1ECL1 G H W P Y ECL1ICL2 P A W W S T V Q ICL2ECL2 R L H Q E H F P A R L Q C V V D Y G G ECL2ICL3 A A ICL3ECL3 A P N ECL3N-term M G N D S V S Y E Y G D Y S D L S D R P V D C L D G A C L A I N-termC-term R A Q L R R S L P A A C H W A L R E S Q G Q D E S V D S K K S T S H D L V S E M E V C-term D P L R V A P L P L Y A A I F L V G V P G N A M V A W V A G K V R V G A T W L L H L A V A D L L C C L S L P I L A V P I A R G G A V G C R A L P S I I L L T M Y A S V L L L A A L S A D L C F L A L G R A C G V Q V A C G A A W T L A L L L T V P S A I Y R S S S T E N A V T A I R F L F G F L G P L V A V A S C H S A L L C W R R C R P L G T A I V V G F F V C W A P Y H L L G L V L T V A S A L L A R A L R A E P L I V G L A L A H S C L N P M L F L Y F G
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

A N G P V G V L F I A A Y L P L P A V R 1 L H L A V A D L L C C L S L P I L A V P 2 A A L L L V S A Y M T L L I I S P L A R 3 V Q V A C G A A W T L A L L L T V P S 4 H C S A V A V L P G L F G F L F R I A T V 5 T A I V V G F F V C W A P Y H L L G L V 6 M P N L C S H A L A L G V I L P E A R 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

PHYSIOLOGICAL LIGANDS

C5a, C5a des-Arg

STRUCTURE MODELS

c5ar2_human inactive,

c5ar2_human active

STRUCTURES

No structures available