C5a2 receptor (c5ar2_human)
FAMILY
Class A (Rhodopsin) Peptide receptors Complement peptide receptors C5a2 receptor
GENE
C5AR2 (C5L2, GPR77)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
C5a anaphylatoxin chemotactic receptor 2, Complement component 5a receptor 2, G-protein coupled receptor 77
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
G
|
N
|
D
|
S
|
V
|
S
|
Y
|
E
|
Y
|
10 |
G
|
D
|
Y
|
S
|
D
|
L
|
S
|
D
|
R
|
P
|
20 |
V
|
D
|
C
|
L
|
D
|
G
|
A
|
C
|
L
|
A
|
30 |
TM1 | |||||||||
I
|
D
|
P
|
L
|
R
|
V
|
A
|
P
|
L
|
P
|
40 |
L
|
Y
|
A
|
A
|
I
|
F
|
L
|
V
|
G
|
V
|
50 |
P
|
G
|
N
|
A
|
M
|
V
|
A
|
W
|
V
|
A
|
60 |
ICL1 | TM2 | ||||||||
G
|
K
|
V
|
A
|
R
|
R
|
R
|
V
|
G
|
A
|
70 |
T
|
W
|
L
|
L
|
H
|
L
|
A
|
V
|
A
|
D
|
80 |
L
|
L
|
C
|
C
|
L
|
S
|
L
|
P
|
I
|
L
|
90 |
A
|
V
|
P
|
I
|
A
|
R
|
G
|
G
|
H
|
W
|
100 |
ECL1 | TM3 | ||||||||
P
|
Y
|
G
|
A
|
V
|
G
|
C
|
R
|
A
|
L
|
110 |
P
|
S
|
I
|
I
|
L
|
L
|
T
|
M
|
Y
|
A
|
120 |
S
|
V
|
L
|
L
|
L
|
A
|
A
|
L
|
S
|
A
|
130 |
D
|
L
|
C
|
F
|
L
|
A
|
L
|
G
|
P
|
A
|
140 |
ICL2 | TM4 | ||||||||
W
|
W
|
S
|
T
|
V
|
Q
|
R
|
A
|
C
|
G
|
150 |
V
|
Q
|
V
|
A
|
C
|
G
|
A
|
A
|
W
|
T
|
160 |
L
|
A
|
L
|
L
|
L
|
T
|
V
|
P
|
S
|
A
|
170 |
ECL2 | |||||||||
I
|
Y
|
R
|
R
|
L
|
H
|
Q
|
E
|
H
|
F
|
180 |
P
|
A
|
R
|
L
|
Q
|
C
|
V
|
V
|
D
|
Y
|
190 |
TM5 | |||||||||
G
|
G
|
S
|
S
|
S
|
T
|
E
|
N
|
A
|
V
|
200 |
T
|
A
|
I
|
R
|
F
|
L
|
F
|
G
|
F
|
L
|
210 |
G
|
P
|
L
|
V
|
A
|
V
|
A
|
S
|
C
|
H
|
220 |
ICL3 | |||||||||
S
|
A
|
L
|
L
|
C
|
W
|
A
|
A
|
R
|
R
|
230 |
TM6 | |||||||||
C
|
R
|
P
|
L
|
G
|
T
|
A
|
I
|
V
|
V
|
240 |
G
|
F
|
F
|
V
|
C
|
W
|
A
|
P
|
Y
|
H
|
250 |
L
|
L
|
G
|
L
|
V
|
L
|
T
|
V
|
A
|
A
|
260 |
ECL3 | TM7 | ||||||||
P
|
N
|
S
|
A
|
L
|
L
|
A
|
R
|
A
|
L
|
270 |
R
|
A
|
E
|
P
|
L
|
I
|
V
|
G
|
L
|
A
|
280 |
L
|
A
|
H
|
S
|
C
|
L
|
N
|
P
|
M
|
L
|
290 |
F
|
L
|
Y
|
F
|
G
|
R
|
A
|
Q
|
L
|
R
|
300 |
C-term | |||||||||
R
|
S
|
L
|
P
|
A
|
A
|
C
|
H
|
W
|
A
|
310 |
L
|
R
|
E
|
S
|
Q
|
G
|
Q
|
D
|
E
|
S
|
320 |
V
|
D
|
S
|
K
|
K
|
S
|
T
|
S
|
H
|
D
|
330 |
L
|
V
|
S
|
E
|
M
|
E
|
V
|
LINKS
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
C5a, C5a des-Arg
STRUCTURE MODELS
STRUCTURES
No structures available