DP1 receptor (pd2r_human)
FAMILY
Class A (Rhodopsin) Lipid receptors Prostanoid receptors DP1 receptor
GENE
PTGDR
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Prostaglandin D2 receptor, PGD receptor, PGD2 receptor, Prostanoid DP receptor
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
K
|
S
|
P
|
F
|
Y
|
R
|
C
|
Q
|
N
|
10 |
T
|
T
|
S
|
V
|
E
|
K
|
G
|
N
|
S
|
A
|
20 |
TM1 | |||||||||
V
|
M
|
G
|
G
|
V
|
L
|
F
|
S
|
T
|
G
|
30 |
L
|
L
|
G
|
N
|
L
|
L
|
A
|
L
|
G
|
L
|
40 |
ICL1 | |||||||||
L
|
A
|
R
|
S
|
G
|
L
|
G
|
W
|
C
|
S
|
50 |
R
|
R
|
P
|
L
|
R
|
P
|
L
|
P
|
S
|
V
|
60 |
TM2 | |||||||||
F
|
Y
|
M
|
L
|
V
|
C
|
G
|
L
|
T
|
V
|
70 |
T
|
D
|
L
|
L
|
G
|
K
|
C
|
L
|
L
|
S
|
80 |
P
|
V
|
V
|
L
|
A
|
A
|
Y
|
A
|
Q
|
N
|
90 |
ECL1 | TM3 | ||||||||
R
|
S
|
L
|
R
|
V
|
L
|
A
|
P
|
A
|
L
|
100 |
D
|
N
|
S
|
L
|
C
|
Q
|
A
|
F
|
A
|
F
|
110 |
F
|
M
|
S
|
F
|
F
|
G
|
L
|
S
|
S
|
T
|
120 |
L
|
Q
|
L
|
L
|
A
|
M
|
A
|
L
|
E
|
C
|
130 |
ICL2 | |||||||||
W
|
L
|
S
|
L
|
G
|
H
|
P
|
F
|
F
|
Y
|
140 |
TM4 | |||||||||
R
|
R
|
H
|
I
|
T
|
L
|
R
|
L
|
G
|
A
|
150 |
L
|
V
|
A
|
P
|
V
|
V
|
S
|
A
|
F
|
S
|
160 |
L
|
A
|
F
|
C
|
A
|
L
|
P
|
F
|
M
|
G
|
170 |
ECL2 | |||||||||
F
|
G
|
K
|
F
|
V
|
Q
|
Y
|
C
|
P
|
G
|
180 |
T
|
W
|
C
|
F
|
I
|
Q
|
M
|
V
|
H
|
E
|
190 |
TM5 | |||||||||
E
|
G
|
S
|
L
|
S
|
V
|
L
|
G
|
Y
|
S
|
200 |
V
|
L
|
Y
|
S
|
S
|
L
|
M
|
A
|
L
|
L
|
210 |
V
|
L
|
A
|
T
|
V
|
L
|
C
|
N
|
L
|
G
|
220 |
A
|
M
|
R
|
N
|
L
|
Y
|
A
|
M
|
H
|
R
|
230 |
R
|
L
|
Q
|
R
|
H
|
P
|
R
|
S
|
C
|
T
|
240 |
ICL3 | |||||||||
R
|
D
|
C
|
A
|
E
|
P
|
R
|
A
|
D
|
G
|
250 |
TM6 | |||||||||
R
|
E
|
A
|
S
|
P
|
Q
|
P
|
L
|
E
|
E
|
260 |
L
|
D
|
H
|
L
|
L
|
L
|
L
|
A
|
L
|
M
|
270 |
T
|
V
|
L
|
F
|
T
|
M
|
C
|
S
|
L
|
P
|
280 |
V
|
I
|
Y
|
R
|
A
|
Y
|
Y
|
G
|
A
|
F
|
290 |
ECL3 | TM7 | ||||||||
K
|
D
|
V
|
K
|
E
|
K
|
N
|
R
|
T
|
S
|
300 |
E
|
E
|
A
|
E
|
D
|
L
|
R
|
A
|
L
|
R
|
310 |
F
|
L
|
S
|
V
|
I
|
S
|
I
|
V
|
D
|
P
|
320 |
H8 | |||||||||
W
|
I
|
F
|
I
|
I
|
F
|
R
|
S
|
P
|
V
|
330 |
F
|
R
|
I
|
F
|
F
|
H
|
K
|
I
|
F
|
I
|
340 |
C-term | |||||||||
R
|
P
|
L
|
R
|
Y
|
R
|
S
|
R
|
C
|
S
|
350 |
N
|
S
|
T
|
N
|
M
|
E
|
S
|
S
|
L
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
PGF2α, PGI2, PGJ2, PGD2, thromboxane A2, PGE1, PGE2
STRUCTURE MODELS
STRUCTURES
No structures available