DP1 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

D

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8ZVZ

RESOLUTION

2.4 Å

REFERENCE

PUBLICATION DATE

May 28, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

50 interactions (Click to see)

LIGANDS

CHEMBL1591294 - Agonist chembl_ligand pubchem pubchem

PHYSIOLOGICAL LIGANDS

PGF2α, PGE1, Δ12-PGJ2, PGE2, PGD2, PGI2, thromboxane A2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 F 138 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 F 138 34x51 G.H5 I 383 G.H5.15
Hydrophobic ICL2 P 137 34x50 G.H5 Q 384 G.H5.16
Van-der-waals ICL2 P 137 34x50 G.H5 Q 384 G.H5.16
Polar TM3 S 133 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 S 133 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 S 133 3x53 G.H5 H 387 G.H5.19
Aromatic TM2 F 61 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM2 F 61 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 F 61 2x39 G.H5 Y 391 G.H5.23
Polar TM3 S 133 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 S 133 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL3 H 235 - G.S6 P 361 G.S6.03
Van-der-waals ICL3 H 235 - G.S6 P 361 G.S6.03
Ionic TM6 E 260 6x30 G.H5 R 385 G.H5.17
Polar TM6 E 260 6x30 G.H5 R 385 G.H5.17
Hydrophobic ICL2 R 141 34x54 G.H5 I 383 G.H5.15
Hydrophobic ICL2 R 142 34x55 G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 R 142 34x55 G.hns1 A 39 G.hns1.03
Hydrophobic TM4 T 145 4x38 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 R 141 34x54 G.H5 M 386 G.H5.18
Hydrophobic TM5 L 225 5x63 G.H5 L 388 G.H5.20
Hydrophobic TM6 H 263 6x33 G.H5 L 388 G.H5.20
Polar ICL2 R 142 34x55 G.HN Q 35 G.HN.52
Van-der-waals ICL2 R 142 34x55 G.HN Q 35 G.HN.52
Polar TM3 E 129 3x49 G.H5 Q 390 G.H5.22
Van-der-waals TM3 E 129 3x49 G.H5 Q 390 G.H5.22
Hydrophobic ICL4 R 327 - G.H5 L 393 G.H5.25
Ionic TM5 R 231 5x69 G.H5 D 381 G.H5.13
Polar TM5 R 231 5x69 G.H5 D 381 G.H5.13
Hydrophobic TM5 R 231 5x69 G.H5 D 381 G.H5.13
Van-der-waals TM5 R 231 5x69 G.H5 D 381 G.H5.13
Hydrophobic TM6 E 260 6x30 G.H5 L 388 G.H5.20
Hydrophobic ICL3 P 236 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 P 236 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL2 F 138 34x51 G.H5 R 380 G.H5.12
Van-der-waals ICL2 F 138 34x51 G.H5 R 380 G.H5.12
Aromatic ICL2 F 138 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 138 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 138 34x51 G.S1 H 41 G.S1.02
Polar TM5 M 228 5x66 G.H5 R 385 G.H5.17
Hydrophobic TM5 M 228 5x66 G.H5 R 385 G.H5.17
Van-der-waals TM5 M 228 5x66 G.H5 R 385 G.H5.17
Polar ICL3 H 235 - G.S6 C 359 G.S6.01
Hydrophobic ICL3 H 235 - G.S6 C 359 G.S6.01
Van-der-waals ICL3 H 235 - G.S6 C 359 G.S6.01
Hydrophobic ICL2 P 137 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 137 34x50 G.H5 I 383 G.H5.15
Polar ICL2 R 142 34x55 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 R 142 34x55 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 P 137 34x50 G.H5 H 387 G.H5.19
Van-der-waals ICL2 P 137 34x50 G.H5 H 387 G.H5.19
Hydrophobic TM5 L 232 5x70 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 L 232 5x70 G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL2 R 141 34x54 G.H5 H 387 G.H5.19
Hydrophobic TM2 F 61 2x39 G.H5 L 393 G.H5.25
Aromatic ICL2 F 138 34x51 G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 138 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 138 34x51 G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 138 34x51 G.S3 F 219 G.S3.03
Polar TM3 E 129 3x49 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 R 141 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 R 141 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic TM5 M 228 5x66 G.H5 L 388 G.H5.20
Polar TM5 R 231 5x69 G.H5 Q 384 G.H5.16
Van-der-waals TM5 R 231 5x69 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 134 3x54 G.H5 Y 391 G.H5.23
Van-der-waals H8 P 329 8x49 G.H5 L 393 G.H5.25
Hydrophobic ICL3 H 235 - G.H4 L 346 G.H4.16
Van-der-waals ICL3 H 235 - G.H4 L 346 G.H4.16
Hydrophobic TM2 Y 62 2x40 G.H5 L 393 G.H5.25
Aromatic ICL2 Y 140 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 Y 140 34x53 G.H5 H 387 G.H5.19
Van-der-waals ICL2 Y 140 34x53 G.H5 H 387 G.H5.19
Hydrophobic TM5 M 228 5x66 G.H5 Q 384 G.H5.16
Van-der-waals TM5 M 228 5x66 G.H5 Q 384 G.H5.16
Polar TM3 L 134 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 134 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 134 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM5 L 232 5x70 G.H5 R 385 G.H5.17
Van-der-waals TM5 L 232 5x70 G.H5 R 385 G.H5.17
Hydrophobic TM2 F 61 2x39 G.H5 Q 390 G.H5.22
Polar ICL3 L 258 - G.H5 E 392 G.H5.24
Hydrophobic ICL3 L 258 - G.H5 E 392 G.H5.24
Hydrophobic ICL3 H 235 - G.h4s6 T 350 G.h4s6.03
Polar TM6 H 263 6x33 G.H5 Y 391 G.H5.23
Hydrophobic TM6 H 263 6x33 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 F 138 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 F 138 34x51 G.S3 V 217 G.S3.01
Polar TM3 C 130 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 C 130 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 C 130 3x50 G.H5 Y 391 G.H5.23
Polar TM3 S 133 3x53 G.H5 Q 390 G.H5.22
Polar ICL2 Y 140 34x53 G.H5 Q 390 G.H5.22
Van-der-waals ICL2 Y 140 34x53 G.H5 Q 390 G.H5.22