MC3 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8IOC

RESOLUTION

2.9 Å

REFERENCE

10.1107/S0907444909042073

PUBLICATION DATE

Sept. 20, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

76 interactions (Click to see)

LIGANDS

γ-MSH - Agonist pubchem gtoplig pubchem

PHYSIOLOGICAL LIGANDS

γ-MSH, agouti-related protein, β-MSH, α-MSH, ACTH



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 150 - G.S3 F 219 G.S3.03
Hydrophobic ICL2 R 151 - G.S3 V 217 G.S3.01
Aromatic ICL2 H 153 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 H 153 - G.hns1 R 38 G.hns1.02
Hydrophobic TM5 V 218 5x69 G.H5 L 394 G.H5.26
Van-der-waals TM5 V 218 5x69 G.H5 L 394 G.H5.26
Polar TM5 H 217 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 H 217 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM3 T 145 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 T 145 3x53 G.H5 H 387 G.H5.19
Polar ICL2 L 150 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 150 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 150 - G.S1 H 41 G.S1.02
Hydrophobic TM4 T 157 4x38 G.HN Q 35 G.HN.52
Van-der-waals TM4 T 157 4x38 G.HN Q 35 G.HN.52
Hydrophobic TM5 F 213 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 F 213 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 146 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 146 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM6 K 239 6x32 G.H5 E 392 G.H5.24
Van-der-waals TM6 K 239 6x32 G.H5 E 392 G.H5.24
Hydrophobic ICL2 L 150 - G.H5 I 383 G.H5.15
Polar ICL2 R 151 - G.s2s3 K 216 G.s2s3.02
Van-der-waals ICL2 R 151 - G.s2s3 K 216 G.s2s3.02
Hydrophobic TM5 F 213 5x64 G.H5 L 388 G.H5.20
Ionic TM5 H 217 5x68 G.H5 D 381 G.H5.13
Polar TM5 H 217 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM5 H 217 5x68 G.H5 D 381 G.H5.13
Van-der-waals TM5 H 217 5x68 G.H5 D 381 G.H5.13
Polar TM5 H 217 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 H 217 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 H 217 5x68 G.H5 Q 384 G.H5.16
Polar TM6 T 243 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM6 T 243 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 T 243 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM2 M 73 2x39 G.H5 Q 390 G.H5.22
Hydrophobic ICL3 P 226 - G.h4s6 T 350 G.h4s6.03
Van-der-waals ICL3 P 226 - G.h4s6 T 350 G.h4s6.03
Hydrophobic TM6 G 240 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM5 H 217 5x68 G.H5 L 394 G.H5.26
Van-der-waals TM5 H 217 5x68 G.H5 L 394 G.H5.26
Hydrophobic TM5 I 221 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 I 221 5x72 G.H5 R 385 G.H5.17
Hydrophobic ICL3 L 224 - G.H4 L 346 G.H4.16
Van-der-waals ICL3 L 224 - G.H4 L 346 G.H4.16
Polar TM3 I 146 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 146 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 146 3x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 L 150 - G.H5 R 380 G.H5.12
Hydrophobic TM5 I 221 5x72 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 I 221 5x72 G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL2 L 150 - G.S3 V 217 G.S3.01
Hydrophobic ICL2 L 150 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 150 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 S 154 - G.hns1 A 39 G.hns1.03
Hydrophobic ICL3 P 225 - G.H4 L 346 G.H4.16
Van-der-waals ICL3 P 225 - G.H4 L 346 G.H4.16
Hydrophobic ICL2 A 149 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 A 149 - G.H5 I 383 G.H5.15
Ionic TM5 R 220 5x71 G.H5 D 381 G.H5.13
Polar TM5 R 220 5x71 G.H5 D 381 G.H5.13
Van-der-waals TM5 R 220 5x71 G.H5 D 381 G.H5.13
Hydrophobic ICL3 P 225 - G.H4 D 343 G.H4.13
Van-der-waals ICL3 P 225 - G.H4 D 343 G.H4.13
Hydrophobic TM5 A 214 5x65 G.H5 L 388 G.H5.20
Hydrophobic TM3 I 146 3x54 G.H5 H 387 G.H5.19
Van-der-waals TM3 I 146 3x54 G.H5 H 387 G.H5.19
Polar TM6 S 236 6x29 G.H5 L 394 G.H5.26
Hydrophobic TM6 S 236 6x29 G.H5 L 394 G.H5.26
Van-der-waals TM6 S 236 6x29 G.H5 L 394 G.H5.26
Hydrophobic ICL2 A 149 - G.H5 Q 384 G.H5.16
Hydrophobic ICL2 L 150 - G.H5 C 379 G.H5.11
Hydrophobic ICL2 A 149 - G.H5 R 380 G.H5.12
Aromatic TM3 R 142 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 142 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 142 3x50 G.H5 Y 391 G.H5.23
Ionic ICL4 R 302 - G.H5 E 392 G.H5.24
Polar ICL4 R 302 - G.H5 E 392 G.H5.24
Hydrophobic ICL4 R 302 - G.H5 E 392 G.H5.24
Van-der-waals ICL4 R 302 - G.H5 E 392 G.H5.24
Polar ICL2 H 153 - G.HN Q 35 G.HN.52
Hydrophobic TM5 A 214 5x65 G.H5 L 394 G.H5.26
Hydrophobic ICL3 L 224 - G.h4s6 T 350 G.h4s6.03
Van-der-waals ICL3 L 224 - G.h4s6 T 350 G.h4s6.03
Hydrophobic TM5 F 211 5x62 G.H5 L 393 G.H5.25
Van-der-waals TM5 F 211 5x62 G.H5 L 393 G.H5.25
Hydrophobic TM5 A 214 5x65 G.H5 L 393 G.H5.25
Hydrophobic TM3 I 146 3x54 G.H5 Y 391 G.H5.23
Polar TM3 T 145 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 T 145 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 T 145 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM5 M 210 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 M 210 5x61 G.H5 L 393 G.H5.25